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Memantine: History, Community, Culture & Applications

Memantine, sold under the brand name Namenda among others, is a medication used to slow the progression of moderate-to-severe Alzheimer's disease. It is taken by mouth.

Language: English [EN]
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Memantine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Memantine.

Related topics
177
Source areas
7
Connected nodes
184
Extracted relationships
218
Concept neighborhoods
32
Bridge connections
184

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 88 topics
Research · 40 topics
History · 18 topics
Adverse effects · 10 topics
Society and culture · 10 topics
Medical uses · 6 topics
Chemistry · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image · as HCl: Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06DX01 (WHO)
Bioavailability
100%
CAS Number
19982-08-2 Y · as HCl: 41100-52-1
ChEBI
CHEBI:64312 · as HCl: CHEBI:64323

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Memantine connects Entity context

The extracted context around Memantine shows recurring relationship patterns in the source. For example, Memantine → Abixa, Adaxor, Admed, Akatinol, Alceba, Alios, Almenta, Alois, Alzant, Alzer, Alzia, Alzinex, Alzixa, Alzmenda, Alzmex, As, August, Axura, Biomentin, Carrier Another extracted example is Memantine → Alzheimer's, Axura, By, CNS, Company, Eli Lilly, Germany, However, It, Merz, NMDA, Parkinson's, Prior, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Memantine

Top relations

related to Brand names · 115
Memantine → Abixa, Adaxor, Admed, Akatinol, Alceba, Alios, Almenta, Alois, Alzant, Alzer, Alzia, Alzinex, Alzixa, Alzmenda, Alzmex, As, August, Axura, Biomentin, Carrier
related to history · 14
Memantine → Alzheimer's, Axura, By, CNS, Company, Eli Lilly, Germany, However, It, Merz, NMDA, Parkinson's, Prior, The
related to Psychiatric disorders · 7
Memantine → BED, Cochrane, Hedges, However, OCD, PDDs, These
related to Recreational use · 7
Memantine → Even, In, It, NMDA, PCP, Recreational, Reddit
has effect · 6
Memantine → Additionally, Common, Despite, Less, Like, NMDA
related to Parkinson's disease · 6
Memantine → Although, However, Parkinson's, Similarly, The, Whereas
Legal status · 5
Memantine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Alzheimer's disease and dementia · 4
Memantine → AChE, Alzheimer's, One, There
related to Apathy · 4
Memantine → Alzheimer's, Apathy, However, Systematic
3D model (JSmol) · 2
Memantine → as HCl: Interactive image, Interactive image

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

disease receptor nmda treatment affinity effects alzheimer's drug amantadine however receptors parkinson's antagonist use used may include review ic50 nm

Memantine relationships Subject–Predicate–Object triples

TTTA extracted 218 structured relationships around Memantine. Examples in this analysis include Memantine → 3D model (JSmol) → Interactive image and Memantine → 3D model (JSmol) → as HCl: Interactive image. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Memantine3D model (JSmol)Interactive image1.00infobox
Memantine3D model (JSmol)as HCl: Interactive image1.00infobox
MemantineAHFS/Drugs.comMonograph1.00infobox
MemantineATC codeN06DX01 (WHO)1.00infobox
MemantineBioavailability100%1.00infobox
MemantineCAS Number19982-08-2 Y1.00infobox
MemantineCAS Numberas HCl: 41100-52-11.00infobox
MemantineChEBICHEBI:643121.00infobox
MemantineChEBIas HCl: CHEBI:643231.00infobox
MemantineChEMBLChEMBL807 Y1.00infobox
MemantineChEMBLas HCl: ChEMBL16991.00infobox
MemantineChemSpider3914 Y1.00infobox
MemantineChemSpideras HCl: 1578491.00infobox
MemantineCompTox Dashboard (EPA)DTXSID50451741.00infobox
MemantineDrug classNMDA receptor antagonist1.00infobox
MemantineDrugBankDB01043 Y1.00infobox
MemantineDrugBankas HCl: DBSALT0004561.00infobox
MemantineECHA InfoCard100.217.9371.00infobox
MemantineElimination half-life60–80 hours1.00infobox
MemantineExcretionUrine (57–82% unchanged)1.00infobox
MemantineFormulaC12H21N1.00infobox
MemantineIUPHAR/BPS42531.00infobox
MemantineKEGGD08174 Y1.00infobox
MemantineKEGGas HCl: D049051.00infobox
MemantineLegal statusAU: S4 (Prescription only)1.00infobox
MemantineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
MemantineLegal statusUK: POM (Prescription only)1.00infobox
MemantineLegal statusUS: ℞-only1.00infobox
MemantineLegal statusEU: Rx-only1.00infobox
MemantineLicense dataUS DailyMed: Memantine1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Memantine bring nearby vocabulary together. In this analysis, examples include Treatment, Receptor and Disease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Memantine
    • Treatment
    • Receptor
    • Disease
    • Nmda
    • Amantadine
    • Affinity
    • Parkinson's
    • Used
    • Alzheimer's
    • However
    • Effects
    • Systematic
  • memantine
    • Treatment
    • Receptor
    • Disease
    • Nmda
    • Amantadine
    • Affinity
    • Parkinson's
    • Used
    • Alzheimer's
    • However
    • Effects
    • Systematic
  • alzheimer's disease
    • Disease
    • Parkinson's
    • Treatment
    • Brand
    • Moderate-to-severe
    • Name
    • Namenda
    • Memantine
    • Drug
    • Glutamatergic
    • Used
    • Amantadine
  • nmda receptors
    • Receptors
    • Receptor
    • Antagonist
    • Higher
    • Affinity
    • Glutamatergic
    • Binding
    • Nm
    • Ic50
    • Activity
    • Μm
    • Doses
  • antagonist at glutamatergic nmda receptors
    • Ic50
    • Receptor
    • Receptors
    • Nm
    • Μm
    • Affinity
    • Antagonist
    • Glutamatergic
    • Nmda
    • Binding
    • Higher
    • Activity
  • non-competitive antagonist
    • Ic50
    • Receptor
    • Nm
    • Μm
    • Affinity
    • Glutamatergic
    • Nmda
    • Binding
    • Higher
    • Receptors
    • Effects
    • Brand
  • parkinson's disease
    • Parkinson's
    • Treatment
    • Amantadine
    • Memantine
    • Used
    • Drug
    • Moderate-to-severe
    • Name
    • Namenda
    • Effects
    • Glutamatergic
    • Dementia
  • memantine/donepezil
    • Treatment
    • Receptor
    • Disease
    • Nmda
    • Amantadine
    • Affinity
    • Parkinson's
    • Used
    • Alzheimer's
    • However
    • Effects
    • Systematic

Connections between topic areas Semantic bridges

For Memantine, one of the stronger structural bridges in this analysis connects Memantine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MemantineOverview · splits 96 ⟂ 89
MemantineResearch · splits 144 ⟂ 41
MemantineHistory · splits 166 ⟂ 19
MemantineAdverse effects · splits 174 ⟂ 11
MemantineSociety and culture · splits 174 ⟂ 11
MemantineMedical uses · splits 178 ⟂ 7
MemantineChemistry · splits 179 ⟂ 6

Map overview Semantic statistics

Memantine

Nodes185
Edges184
Triples218
Avg. degree1.99
Density0.010811
Components1

Source & methodology

TTTA analyzes the structure around Memantine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Memantine · EN edition · Analysis: TopicsToTalkAbout

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