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Nitric oxide synthase: Products, Mammalian isoforms & Structure

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter.…

Language: English [EN]
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Nitric oxide synthase topic overview

The analysis highlights Products, Mammalian isoforms and Structure as prominent areas in the source structure around Nitric oxide synthase.

Related topics
104
Source areas
8
Connected nodes
112
Extracted relationships
48
Concept neighborhoods
27
Bridge connections
112

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 33 topics
Mammalian isoforms · 24 topics
Structure · 18 topics
Inhibitors · 15 topics
Function · 8 topics
Species distribution · 4 topics
In non-mammal eukaryotes · 1 topics
In prokaryotes · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
125978-95-2
EC no.
1.14.13.39
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Species distribution

Function

Mammalian isoforms

Structure

Inhibitors

In non-mammal eukaryotes

In prokaryotes

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Nitric oxide synthase connects Entity context

The extracted context around Nitric oxide synthase shows recurring relationship patterns in the source. For example, Nitric oxide synthase → As, BH2, BH4, Ca2, Chromosome, Endothelial NOS, Golgi, N-terminal, NO, NOS, NOS3, The, These Another extracted example is Nitric oxide synthase → Chemistry, Edinburgh, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Nitric, NO SynthaseNitric Oxide Synthase, Physiology, Proteopedia, School, The Nobel Prize. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nitric oxide synthase

Top relations

related to eNOS · 13
Nitric oxide synthase → As, BH2, BH4, Ca2, Chromosome, Endothelial NOS, Golgi, N-terminal, NO, NOS, NOS3, The, These
related to External links · 12
Nitric oxide synthase → Chemistry, Edinburgh, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Nitric, NO SynthaseNitric Oxide Synthase, Physiology, Proteopedia, School, The Nobel Prize
related to Chemical reaction · 10
Nitric oxide synthase → L-Arg, L-arginine, L-citrulline, NADPH, Nitric, NO, NOHLA, Nω-hydroxy-L-arginine, O2, Oxidation
BRENDA · 1
Nitric oxide synthase → enzyme data
CAS no. · 1
Nitric oxide synthase → 125978-95-2
EC no. · 1
Nitric oxide synthase → 1.14.13.39
ExPASy · 1
Nitric oxide synthase → NiceZyme view
Gene Ontology · 1
Nitric oxide synthase → AmiGO / QuickGO
KEGG · 1
Nitric oxide synthase → enzyme entry
MetaCyc · 1
Nitric oxide synthase → metabolic pathway

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nos nitric oxide enos nnos domain inos endothelial synthase may oxygenase cell function heme electron also reductase nadph calmodulin nos3

Nitric oxide synthase relationships Subject–Predicate–Object triples

TTTA extracted 48 structured relationships around Nitric oxide synthase. Examples in this analysis include Nitric oxide synthase → BRENDA → enzyme data and Nitric oxide synthase → CAS no. → 125978-95-2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Nitric oxide synthaseBRENDAenzyme data1.00infobox
Nitric oxide synthaseCAS no.125978-95-21.00infobox
Nitric oxide synthaseEC no.1.14.13.391.00infobox
Nitric oxide synthaseExPASyNiceZyme view1.00infobox
Nitric oxide synthaseGene OntologyAmiGO / QuickGO1.00infobox
Nitric oxide synthaseKEGGenzyme entry1.00infobox
Nitric oxide synthaseMetaCycmetabolic pathway1.00infobox
Nitric oxide synthaseNCBIproteins1.00infobox
Nitric oxide synthasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Nitric oxide synthasePMCarticles1.00infobox
Nitric oxide synthasePubMedarticles1.00infobox
Nitric oxide synthaseRheareactions1.00infobox
Nitric oxide synthaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Nitric oxide synthase bring nearby vocabulary together. In this analysis, examples include Oxide, Synthase and Production. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Nitric oxide synthase
    • Oxide
    • Synthase
    • Production
    • L-arginine
    • Endothelial
    • Enos
    • Nos
    • May
    • Synthases
    • Nnos
    • Isoforms
    • O2
  • nitric oxide synthase
    • Oxide
    • Synthase
    • Production
    • L-arginine
    • Endothelial
    • Enos
    • Nos
    • May
    • Synthases
    • Nnos
    • Isoforms
    • O2
  • nitric oxide
    • Oxide
    • Synthase
    • Production
    • L-arginine
    • Endothelial
    • Enos
    • Nos
    • May
    • Synthases
    • Nnos
    • Isoforms
    • O2
  • endothelial nos
    • Nos3
    • Enos
    • Neuronal
    • Nitric
    • Oxide
    • Nnos
    • Function
    • Synthase
    • Also
    • Nos
    • Found
    • Involved
  • endothelial
    • Nos3
    • Enos
    • Neuronal
    • Nitric
    • Oxide
    • Function
    • Synthase
    • Nos
    • Nnos
    • Found
    • Involved
    • Known
  • endothelial dysfunction
    • Nos3
    • Enos
    • Neuronal
    • Nitric
    • Oxide
    • Function
    • Synthase
    • Nos
    • Nnos
    • Found
    • Involved
    • Known
  • oxygenase domain
    • Reductase
    • Domain
    • Oxygenase
    • Protein
    • Tetrahydrobiopterin
    • Heme
    • Also
    • Nadph
    • Synthases
    • Synthase
    • Nos
    • Isoform
  • function
    • Endothelial
    • Isoforms
    • Involved
    • Nos3
    • Important
    • Also
    • Synthase
    • May
    • Nnos
    • Enos
    • Nitric
    • Oxide

Connections between topic areas Semantic bridges

For Nitric oxide synthase, one of the stronger structural bridges in this analysis connects Nitric oxide synthase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Nitric oxide synthaseOverview · splits 79 ⟂ 34
Nitric oxide synthaseMammalian isoforms · splits 88 ⟂ 25
Nitric oxide synthaseStructure · splits 94 ⟂ 19
Nitric oxide synthaseInhibitors · splits 97 ⟂ 16
Nitric oxide synthaseFunction · splits 104 ⟂ 9
Nitric oxide synthaseSpecies distribution · splits 108 ⟂ 5

Map overview Semantic statistics

Nitric oxide synthase

Nodes113
Edges112
Triples48
Avg. degree1.98
Density0.017699
Components1

Source & methodology

TTTA analyzes the structure around Nitric oxide synthase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Mammalian isoforms & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nitric oxide synthase · EN edition · Analysis: TopicsToTalkAbout

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