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Dextropropoxyphene: History, Community, Culture & Applications

Dextropropoxyphene is an opioid analgesic patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anesthetic effects. The drug has been taken off the market in Europe and the United States due to concerns of fatal…

Language: English [EN]
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Dextropropoxyphene topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Dextropropoxyphene.

Related topics
81
Source areas
8
Connected nodes
89
Extracted relationships
69
Concept neighborhoods
23
Bridge connections
89

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 31 topics
Toxicity · 25 topics
Society and culture · 9 topics
Pharmacology · 8 topics
Medical uses · 4 topics
History · 2 topics
Drug testing · 1 topics
Side effects · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
Low[failed verification]
AHFS/Drugs.com
Monograph
ATC code
N02AC04 (WHO)
Bioavailability
40%
CAS Number
469-62-5 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

Toxicity

History

Society and culture

Drug testing

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dextropropoxyphene connects Entity context

The extracted context around Dextropropoxyphene shows recurring relationship patterns in the source. For example, Dextropropoxyphene → Balacet, Because, Before, Darvocet, FDA-directed, HCl, Napsylate, Propoxyphene, Shortly, The, United States Another extracted example is Dextropropoxyphene → AU: S4 (Prescription only), BR: Class A2 (Narcotic drugs), CA: Schedule I, DE: Anlage II (Authorized trade only, not prescriptible), NZ: Withdrawn (illegal), UK: Class C, US: Schedule II and Schedule IV (when in dosage form). Use these groups to spot repeated connection types before inspecting the individual relationships.

Dextropropoxyphene

Top relations

related to Available forms · 11
Dextropropoxyphene → Balacet, Because, Before, Darvocet, FDA-directed, HCl, Napsylate, Propoxyphene, Shortly, The, United States
Legal status · 7
Dextropropoxyphene → AU: S4 (Prescription only), BR: Class A2 (Narcotic drugs), CA: Schedule I, DE: Anlage II (Authorized trade only, not prescriptible), NZ: Withdrawn (illegal), UK: Class C, US: Schedule II and Schedule IV (when in dosage form)
related to Toxicity · 6
Dextropropoxyphene → An, CNS, Excessive, In, It, Overdose
related to Drug testing · 4
Dextropropoxyphene → Detectable, It, OPI, Propoxyphene
related to Pharmacology · 3
Dextropropoxyphene → It, Morphine, Propoxyphene
related to Usage controversy and regulation · 3
Dextropropoxyphene → Attention, Caution, In
related to Analgesia · 2
Dextropropoxyphene → However, Like
related to history · 2
Dextropropoxyphene → CIA-funded, US Navy
3D model (JSmol) · 1
Dextropropoxyphene → Interactive image
Addiction liability · 1
Dextropropoxyphene → Low[failed verification]

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

propoxyphene paracetamol effects drug patients co-proxamol available opioid alcohol also darvon may withdrawal market anesthetic withdrawn overdose depression pain toxicity

Dextropropoxyphene relationships Subject–Predicate–Object triples

TTTA extracted 69 structured relationships around Dextropropoxyphene. Examples in this analysis include Dextropropoxyphene → 3D model (JSmol) → Interactive image and Dextropropoxyphene → Addiction liability → Low[failed verification]. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dextropropoxyphene3D model (JSmol)Interactive image1.00infobox
DextropropoxypheneAddiction liabilityLow[failed verification]1.00infobox
DextropropoxypheneAHFS/Drugs.comMonograph1.00infobox
DextropropoxypheneATC codeN02AC04 (WHO)1.00infobox
DextropropoxypheneBioavailability40%1.00infobox
DextropropoxypheneCAS Number469-62-5 Y1.00infobox
DextropropoxypheneChEBICHEBI:51173 Y1.00infobox
DextropropoxypheneChEMBLChEMBL1213351 Y1.00infobox
DextropropoxypheneChemSpider9696 Y1.00infobox
DextropropoxypheneCompTox Dashboard (EPA)DTXSID10235241.00infobox
DextropropoxypheneDrug classOpioid1.00infobox
DextropropoxypheneDrugBankDB00647 N1.00infobox
DextropropoxypheneECHA InfoCard100.006.7471.00infobox
DextropropoxypheneElimination half-life6–12 hours; 30–36 hours (active metabolite, nordextropropoxyphene)1.00infobox
DextropropoxypheneExcretionUrine (major), breastmilk (minor)1.00infobox
DextropropoxypheneFormulaC22H29NO21.00infobox
DextropropoxypheneIUPHAR/BPS75931.00infobox
DextropropoxypheneKEGGD07809 Y1.00infobox
DextropropoxypheneLegal statusAU: S4 (Prescription only)1.00infobox
DextropropoxypheneLegal statusBR: Class A2 (Narcotic drugs)1.00infobox
DextropropoxypheneLegal statusCA: Schedule I1.00infobox
DextropropoxypheneLegal statusDE: Anlage II (Authorized trade only, not prescriptible)1.00infobox
DextropropoxypheneLegal statusNZ: Withdrawn (illegal)1.00infobox
DextropropoxypheneLegal statusUK: Class C1.00infobox
DextropropoxypheneLegal statusUS: Schedule II and Schedule IV (when in dosage form)1.00infobox
DextropropoxypheneLicense dataUS FDA: Propoxyphene1.00infobox
DextropropoxypheneMedlinePlusa6823251.00infobox
DextropropoxypheneMelting point75 °C (167 °F)1.00infobox
DextropropoxypheneMetabolismLiver-mediated, CYP3A4-mediated N-demethylation (major), aromatic hydroxylation (minor) and ester hydrolysis (minor)1.00infobox
DextropropoxypheneMolar mass339.479 g·mol−11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dextropropoxyphene bring nearby vocabulary together. In this analysis, examples include Paracetamol, Available and United. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dextropropoxyphene
    • Paracetamol
    • Available
    • United
    • Mg
    • Use
    • Withdrawn
    • Darvon
    • Patients
    • Names
    • Australia
    • However
    • Products
  • dextropropoxyphene
    • Paracetamol
    • Available
    • United
    • Mg
    • Use
    • Withdrawn
    • Darvon
    • Patients
    • Names
    • Australia
    • However
    • Products
  • side effects
    • Local
    • Opioid
    • May
    • Depression
    • Pain
    • Result
    • Toxicity
    • Uk
    • Weak
    • Propoxyphene
    • Drug
    • Name
  • drug testing
    • Fda
    • Alcohol
    • Darvon
    • Market
    • Propoxyphene
    • United
    • Drugs
    • Used
    • Toxicity
    • Weak
    • Withdrawn
    • Patients
  • excessive amounts of alcohol
    • Drug
    • Used
    • Darvon
    • Depression
    • Market
    • Dextropropoxyphene
    • Pain
    • Products
    • Result
    • Mg
    • Toxicity
    • Uk
  • alcohol
    • Drug
    • Used
    • Darvon
    • Depression
    • Market
    • Dextropropoxyphene
    • Pain
    • Products
    • Result
    • Mg
    • Toxicity
    • Uk
  • british approved name
    • Names
    • Withdrawn
    • Available
    • Co-proxamol
    • European
    • Fda
    • However
    • United
    • Drugs
    • Paracetamol
    • Opioid
    • Toxicity
  • pulmonary toxicity
    • Result
    • Liver
    • Uk
    • Depression
    • Overdose
    • European
    • Fda
    • United
    • Dose
    • Opioid
    • Use
    • Weak

Connections between topic areas Semantic bridges

For Dextropropoxyphene, one of the stronger structural bridges in this analysis connects Dextropropoxyphene with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dextropropoxyphene — Overview · splits 58 ⟂ 32
Dextropropoxyphene — Toxicity · splits 64 ⟂ 26
Dextropropoxyphene — Society and culture · splits 80 ⟂ 10
Dextropropoxyphene — Pharmacology · splits 81 ⟂ 9
Dextropropoxyphene — Medical uses · splits 85 ⟂ 5
Dextropropoxyphene — History · splits 87 ⟂ 3

Map overview Semantic statistics

Dextropropoxyphene

Nodes90
Edges89
Triples69
Avg. degree1.98
Density0.022222
Components1

Source & methodology

TTTA analyzes the structure around Dextropropoxyphene to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dextropropoxyphene · EN edition · Analysis: TopicsToTalkAbout

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