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Patch clamp

The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual isolated living cells, tissue sections, or patches of cell membrane. The technique is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells, and can also be applied to…

Standards, Variations & Basic technique

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Overview

Basic technique

Variations

Automatic patch clamping

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Map overview Semantic statistics

Patch clamp

Nodes71
Edges70
Triples73
Avg. degree1.97
Density0.028169
Components1

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Patch clamp

Top relations

related to Perforated patch · 11
Patch clamp → Advantages, As, Ca2, Consequently, Disadvantages, If, Instead, It, The, This, When
related to Loose patch · 8
Patch clamp → Almers, For, Stanfield, Strickholm, Stühmer, The, This, To
related to Patch-Seq · 8
Patch clamp → As, By, Combining, Investigations, It, Patch-seq, RNA, RNA-sequencing
related to Whole-cell recording or whole-cell patch · 8
Patch clamp → After, For, How, Once, The, There, This, Whole-cell
related to Recording · 6
Patch clamp → Alternatively, Current, Many, The, This, To
related to Automatic patch clamping · 5
Patch clamp → Automated, In, PDMS, Such, Then
related to External links · 5
Patch clamp → Biophysics Laboratory TechniquesAlternative, Electrophysiology, Patch Clamp Method Archived, The Axon Guide, Wayback Machine
related to Tissue sectioning · 5
Patch clamp → Accurate, By, Carl Zeiss AG, Leica Biosystems, To
related to Set-up · 4
Patch clamp → An, Another, During, The
see also · 1
Patch clamp → BioelectronicsCable

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Important terminology

patch cell membrane pipette electrode clamp technique current recording used whole-cell cells voltage resistance recordings ion channels currents intracellular channel

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
neuronsinstance ofThe technique is especially useful in the study of excitable cells0.80text
cardiomyocytesinstance ofThe technique is especially useful in the study of excitable cells0.80text
muscle fibersinstance ofThe technique is especially useful in the study of excitable cells0.80text
and pancreatic beta cellsinstance ofThe technique is especially useful in the study of excitable cells0.80text
and can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts.Patch clamping can be performed using the voltage clamp techniqueinstance ofThe technique is especially useful in the study of excitable cells0.80text
action potentialsinstance ofwhich improved understanding of the involvement of channels in fundamental cell processes0.80text
nerve activityinstance ofwhich improved understanding of the involvement of channels in fundamental cell processes0.80text
Ca2instance ofThis property maintains endogenous levels of divalent ions0.80text
electrophysiologyinstance ofBy combining multiple data modalities0.80text
sequencinginstance ofBy combining multiple data modalities0.80text
microscopyinstance ofBy combining multiple data modalities0.80text
Patch-seq allows for neurons to be characterized in multiple ways simultaneouslyinstance ofBy combining multiple data modalities0.80text

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