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Methadone: History, Community, Culture & Applications

Methadone, sold under the brand names Dolophine and Methadose, among others, is a potent synthetic opioid used medically to treat chronic pain and opioid use disorder. Prescribed for daily use, the medicine relieves cravings and opioid withdrawal symptoms. Withdrawal management using methadone can be accomplished in less than a month, or it may be done…

Language: English [EN]
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Methadone topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Methadone.

Related topics
191
Source areas
9
Connected nodes
201
Extracted relationships
186
Related term clusters
36
Bridge connections
201

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 52 topics
Pharmacology · 51 topics
Adverse effects · 38 topics
History · 22 topics
Medical uses · 10 topics
Veterinary use · 8 topics
Regulation · 6 topics
Society and culture · 3 topics
Chemistry · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
High
AHFS/Drugs.com
Monograph
ATC code
N02AC52 (WHO) N07BC02 (WHO) QN02AC90 (WHO)
Bioavailability
Rectal: 76% SC: 79% Oral: 41–99% IV/IM: 100%
CAS Number
76-99-3 Y

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Pharmacology

Chemistry

History

Society and culture

Regulation

Veterinary use

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Methadone connects Entity context

The extracted context around Methadone shows recurring relationship patterns in the source. For example, Methadone → Allies, Bockmühl, Commerce Intelligence, Demerol, Department, Dicodid, Dilaudid, Ehrhart, Farbenindustrie AG, Farbenkonzern, Farbwerke Hoechst, German, Germany, Germany's, Heroin, Hoechst, Morphine, Opana, OxyContin, Permonid Another extracted example is Methadone → According, Although, Approximately, Charleston Gazette, Diskets, Health Statistics, Mental Health Services Administration, Methadone-Associated Mortality, National Assessment, National Center, Report, Substance Abuse, United States, West Virginia. Use these groups to spot repeated connection types before inspecting the individual relationships.

Methadone

Top relations

related to history · 27
Methadone → Allies, Bockmühl, Commerce Intelligence, Demerol, Department, Dicodid, Dilaudid, Ehrhart, Farbenindustrie AG, Farbenkonzern, Farbwerke Hoechst, German, Germany, Germany's, Heroin, Hoechst, Morphine, Opana, OxyContin, Permonid
related to Mortality · 14
Methadone → According, Although, Approximately, Charleston Gazette, Diskets, Health Statistics, Mental Health Services Administration, Methadone-Associated Mortality, National Assessment, National Center, Report, Substance Abuse, United States, West Virginia
related to Economics · 12
Methadone → Alcohol, Drug Dependence Rehabilitation Program, In California, Medicaid, Medicare, Medicare Part, Patients, People, The United States Department, US, VA, Veteran's Affairs
Legal status · 9
Methadone → AU: S8 (Controlled drug), BR: Class A1 (Narcotic drugs), CA: Schedule I, DE: Anlage III (Special prescription form required), EU: Rx-only, NZ: Class B3, SE: Förteckning II, UK: Class A, US: Schedule II
related to Metabolism · 8
Methadone → CYP2B6, CYP2D6, CYP3A4, EDDP, EMDP, Many, N-demethylation, People
related to Route of administration · 8
Methadone → Alka-Seltzer, Diskets, Drinkable, Germany, Injecting, Methadose, Oral, United States
related to United States and Canada · 8
Methadone → ACSCN, Canada, HCl, Narcotic Drugs, Schedule, Schedule II, United Nations Single Convention, United States
related to Driving · 7
Methadone → Drug, IM, Individuals, IV, Queensland, UK, University
related to Opioid addiction · 7
Methadone → Cochrane, DEA, Drug Enforcement Administration, Mental Health Services Administration, SAMHSA, Substance Abuse, US
related to Other countries · 6
Methadone → Chief Sanitary Inspector, China, In Russia, People, Russia Gennadiy Onishchenko, Russian

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

opioid use treatment maintenance withdrawal effects used may drug pain addiction half-life opioids oral administration also doses analgesic united states

Methadone relationships Subject–Predicate–Object triples

TTTA extracted 186 structured relationships around Methadone. Examples in this analysis include Methadone → 3D model (JSmol) → Interactive image and Methadone → Addiction liability → High. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Methadone3D model (JSmol)Interactive image1.00infobox
MethadoneAddiction liabilityHigh1.00infobox
MethadoneAHFS/Drugs.comMonograph1.00infobox
MethadoneATC codeN02AC52 (WHO) N07BC02 (WHO) QN02AC90 (WHO)1.00infobox
MethadoneBioavailabilityRectal: 76% SC: 79% Oral: 41–99% IV/IM: 100%1.00infobox
MethadoneCAS Number76-99-3 Y1.00infobox
MethadoneChEBICHEBI:6807 N1.00infobox
MethadoneChEMBLChEMBL651 Y1.00infobox
MethadoneChemSpider3953 Y1.00infobox
MethadoneChiralityRacemic mixture1.00infobox
MethadoneCompTox Dashboard (EPA)DTXSID70232731.00infobox
MethadoneDrug classOpioid1.00infobox
MethadoneDrugBankDB00333 Y1.00infobox
MethadoneDuration of actionSingle dose: 4–8 h Prolonged use: • Withdrawal prevention: 1–2 days • Pain relief: 8–12 hours1.00infobox
MethadoneECHA InfoCard100.000.9071.00infobox
MethadoneElimination half-life15–55 hours1.00infobox
MethadoneExcretionUrine, faeces1.00infobox
MethadoneFormulaC21H27NO1.00infobox
MethadoneIUPHAR/BPS54581.00infobox
MethadoneKEGGD08195 Y1.00infobox
MethadoneLegal statusAU: S8 (Controlled drug)1.00infobox
MethadoneLegal statusBR: Class A1 (Narcotic drugs)1.00infobox
MethadoneLegal statusCA: Schedule I1.00infobox
MethadoneLegal statusDE: Anlage III (Special prescription form required)1.00infobox
MethadoneLegal statusNZ: Class B31.00infobox
MethadoneLegal statusUK: Class A1.00infobox
MethadoneLegal statusUS: Schedule II1.00infobox
MethadoneLegal statusEU: Rx-only1.00infobox
MethadoneLegal statusSE: Förteckning II1.00infobox
MethadoneLicense dataUS DailyMed: Methadone1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Methadone bring nearby vocabulary together. In this analysis, examples include Treatment, Opioid and Maintenance. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Methadone
    • Treatment
    • Opioid
    • Maintenance
    • Effects
    • Use
    • Pain
    • May
    • Also
    • Drug
    • Administration
    • Sedation
    • States
  • methadone
    • Treatment
    • Opioid
    • Maintenance
    • Effects
    • Use
    • Pain
    • May
    • Also
    • Drug
    • Administration
    • Sedation
    • States
  • opioid
    • Used
    • Addiction
    • Withdrawal
    • Treatment
    • Use
    • Maintenance
    • Dependence
    • Symptoms
    • Administration
    • Pain
    • Prescribed
    • Drug
  • chronic pain
    • Nmda
    • Receptor
    • Administration
    • May
    • Used
    • Analgesic
    • Tolerance
    • Also
    • Opioids
    • Use
    • Drug
    • Effects
  • opioid use disorder
    • Used
    • Addiction
    • Withdrawal
    • Treatment
    • Use
    • Maintenance
    • Dependence
    • Symptoms
    • Prescribed
    • Administration
    • Pain
    • Dose
  • opioid withdrawal
    • Symptoms
    • Used
    • Addiction
    • Opioid
    • Withdrawal
    • Treatment
    • Use
    • Maintenance
    • Dependence
    • Administration
    • Drug
    • Pain
  • opioid abuse
    • Used
    • Addiction
    • Withdrawal
    • Treatment
    • Use
    • Maintenance
    • Dependence
    • Symptoms
    • Administration
    • Pain
    • Prescribed
    • Drug
  • opioid receptors
    • Used
    • Addiction
    • Withdrawal
    • Treatment
    • Use
    • Maintenance
    • Dependence
    • Symptoms
    • Administration
    • Pain
    • Prescribed
    • Drug

Connections between topic areas Semantic bridges

For Methadone, one of the stronger structural bridges in this analysis connects Methadone with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Methadone — Overview · splits 149 ⟂ 53
Methadone — Pharmacology · splits 149 ⟂ 53
Methadone — Adverse effects · splits 163 ⟂ 39
Methadone — History · splits 179 ⟂ 23
Methadone — Medical uses · splits 191 ⟂ 11
Methadone — Veterinary use · splits 193 ⟂ 9
Methadone — Regulation · splits 195 ⟂ 7
Methadone — Society and culture · splits 198 ⟂ 4

Map overview Semantic statistics

Methadone

Nodes202
Edges201
Triples186
Avg. degree1.99
Density0.009901
Components1

Source & methodology

TTTA analyzes the structure around Methadone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Methadone · EN edition · Analysis: TopicsToTalkAbout

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