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Methadone

Methadone, sold under the brand names Dolophine and Methadose, among others, is a potent synthetic opioid used medically to treat chronic pain and opioid use disorder. Prescribed for daily use, the medicine relieves cravings and opioid withdrawal symptoms. Withdrawal management using methadone can be accomplished in less than a month, or it may be done…

History, Community, Culture & Applications

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Explore the main themes, entities and connections around Methadone. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
High
AHFS/Drugs.com
Monograph
ATC code
N02AC52 (WHO) N07BC02 (WHO) QN02AC90 (WHO)
Bioavailability
Rectal: 76% SC: 79% Oral: 41–99% IV/IM: 100%
CAS Number
76-99-3 Y

Topics to explore

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Overview

Medical uses

Adverse effects

Pharmacology

Chemistry

History

Society and culture

Regulation

Veterinary use

Advanced semantic analysis

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Map overview Semantic statistics

Methadone

Nodes204
Edges203
Triples231
Avg. degree1.99
Density0.009804
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Methadone

Top relations

related to history · 32
Methadone → After, Allies, Bockmühl, Commerce Intelligence, Demerol, Department, Dicodid, Dilaudid, Ehrhart, Farbenindustrie AG, Farbenkonzern, Farbwerke Hoechst, German, Germany, Germany's, Heroin, Hoechst, In, It, Morphine
related to Mortality · 17
Methadone → According, Although, Approximately, Charleston Gazette, Diskets, Health Statistics, In, Mental Health Services Administration, Methadone-Associated Mortality, National Assessment, National Center, Report, Substance Abuse, That, The, United States, West Virginia
related to Economics · 13
Methadone → Alcohol, Drug Dependence Rehabilitation Program, In, In California, Medicaid, Medicare, Medicare Part, Patients, People, The United States Department, US, VA, Veteran's Affairs
related to External links · 11
Methadone → Darstellung, DEpatent, Dr Gustav Ehrhart, Dr Max Bockmuehl, Estern, February, IG Farbenindustrie AG Archived, September, Tapering, Verfahren, Wayback Machine
related to Metabolism · 11
Methadone → CYP2B6, CYP2D6, CYP3A4, EDDP, EMDP, However, Many, N-demethylation, People, The, This
related to Driving · 10
Methadone → Drug, However, IM, In, Individuals, IV, Queensland, The, UK, University
related to Opioid addiction · 10
Methadone → Cochrane, DEA, Drug Enforcement Administration, In, It, Its, Mental Health Services Administration, SAMHSA, Substance Abuse, US
related to Route of administration · 10
Methadone → Alka-Seltzer, Diskets, Drinkable, Germany, Injecting, Methadose, Oral, The, These, United States
related to United States and Canada · 10
Methadone → ACSCN, Canada, HCl, In, Narcotic Drugs, Schedule, Schedule II, The, United Nations Single Convention, United States
Legal status · 9
Methadone → AU: S8 (Controlled drug), BR: Class A1 (Narcotic drugs), CA: Schedule I, DE: Anlage III (Special prescription form required), EU: Rx-only, NZ: Class B3, SE: Förteckning II, UK: Class A, US: Schedule II

Important terminology Word statistics

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Important terminology

opioid use treatment maintenance withdrawal effects used may drug pain addiction half-life opioids oral administration also doses analgesic united states

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Methadone3D model (JSmol)Interactive image1.00infobox
MethadoneAddiction liabilityHigh1.00infobox
MethadoneAHFS/Drugs.comMonograph1.00infobox
MethadoneATC codeN02AC52 (WHO) N07BC02 (WHO) QN02AC90 (WHO)1.00infobox
MethadoneBioavailabilityRectal: 76% SC: 79% Oral: 41–99% IV/IM: 100%1.00infobox
MethadoneCAS Number76-99-3 Y1.00infobox
MethadoneChEBICHEBI:6807 N1.00infobox
MethadoneChEMBLChEMBL651 Y1.00infobox
MethadoneChemSpider3953 Y1.00infobox
MethadoneChiralityRacemic mixture1.00infobox
MethadoneCompTox Dashboard (EPA)DTXSID70232731.00infobox
MethadoneDrug classOpioid1.00infobox
MethadoneDrugBankDB00333 Y1.00infobox
MethadoneDuration of actionSingle dose: 4–8 h Prolonged use: • Withdrawal prevention: 1–2 days • Pain relief: 8–12 hours1.00infobox
MethadoneECHA InfoCard100.000.9071.00infobox
MethadoneElimination half-life15–55 hours1.00infobox
MethadoneExcretionUrine, faeces1.00infobox
MethadoneFormulaC21H27NO1.00infobox
MethadoneIUPHAR/BPS54581.00infobox
MethadoneKEGGD08195 Y1.00infobox
MethadoneLegal statusAU: S8 (Controlled drug)1.00infobox
MethadoneLegal statusBR: Class A1 (Narcotic drugs)1.00infobox
MethadoneLegal statusCA: Schedule I1.00infobox
MethadoneLegal statusDE: Anlage III (Special prescription form required)1.00infobox
MethadoneLegal statusNZ: Class B31.00infobox
MethadoneLegal statusUK: Class A1.00infobox
MethadoneLegal statusUS: Schedule II1.00infobox
MethadoneLegal statusEU: Rx-only1.00infobox
MethadoneLegal statusSE: Förteckning II1.00infobox
MethadoneLicense dataUS DailyMed: Methadone1.00infobox

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