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Basic helix–loop–helix: History, Examples & Human proteins with helix–loop–helix DNA-binding domain

A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.

Language: English [EN]
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Basic helix–loop–helix topic overview

The analysis highlights History, Examples and Human proteins with helix–loop–helix DNA-binding domain as prominent areas in the source structure around Basic helix–loop–helix. 3 topics appear in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
138
Source areas
6
Connected nodes
148
Extracted relationships
12
Concept neighborhoods
18
Bridge connections
148

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Human proteins with helix–loop–helix DNA-binding domain · 98 topics
Examples · 22 topics
Overview · 11 topics
Structure · 7 topics
History · 2 topics
Regulation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR001092 · PF00010
Available protein structures:
IPR001092 · PF00010
CDD
cd00083
InterPro
IPR001092
PDB
1a0a​, 1am9​, 1an2​, 1an4​, 1hlo​, 1mdy​, 1nkp​, 1nlw​, 1r05​, 1ukl​, 2ql2​ IPR001092 PF00010 (ECOD; PDBsum)
Pfam
PF00010

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Examples

Regulation

History

Human proteins with helix–loop–helix DNA-binding domain

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Basic helix–loop–helix connects Entity context

The extracted context around Basic helix–loop–helix shows recurring relationship patterns in the source. For example, Basic helix–loop–helix → IPR001092, PF00010 Another extracted example is Basic helix–loop–helix → cd00083. Use these groups to spot repeated connection types before inspecting the individual relationships.

Basic helix–loop–helix

Top relations

AlphaFold · 2
Basic helix–loop–helix → IPR001092, PF00010
Available protein structures: · 2
Basic helix–loop–helix → IPR001092, PF00010
CDD · 1
Basic helix–loop–helix → cd00083
InterPro · 1
Basic helix–loop–helix → IPR001092
PDB · 1
Basic helix–loop–helix → 1a0a​, 1am9​, 1an2​, 1an4​, 1hlo​, 1mdy​, 1nkp​, 1nlw​, 1r05​, 1ukl​, 2ql2​ IPR001092 PF00010 (ECOD; PDBsum)
Pfam · 1
Basic helix–loop–helix → PF00010
PROSITE · 1
Basic helix–loop–helix → PDOC00038
SCOP2 · 1
Basic helix–loop–helix → 1mdy / SCOPe / SUPFAM
SMART · 1
Basic helix–loop–helix → SM00353
Symbol · 1
Basic helix–loop–helix → bHLH

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bhlh transcription loop factors proteins basic dna motif helix one e-box arnt α-helices protein also bind general contain often called

Basic helix–loop–helix relationships Subject–Predicate–Object triples

TTTA extracted 12 structured relationships around Basic helix–loop–helix. Examples in this analysis include Basic helix–loop–helix → AlphaFold → IPR001092 and Basic helix–loop–helix → AlphaFold → PF00010. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Basic helix–loop–helixAlphaFoldIPR0010921.00infobox
Basic helix–loop–helixAlphaFoldPF000101.00infobox
Basic helix–loop–helixAvailable protein structures:IPR0010921.00infobox
Basic helix–loop–helixAvailable protein structures:PF000101.00infobox
Basic helix–loop–helixCDDcd000831.00infobox
Basic helix–loop–helixInterProIPR0010921.00infobox
Basic helix–loop–helixPDB1a0a​, 1am9​, 1an2​, 1an4​, 1hlo​, 1mdy​, 1nkp​, 1nlw​, 1r05​, 1ukl​, 2ql2​ IPR001092 PF00010 (ECOD; PDBsum)1.00infobox
Basic helix–loop–helixPfamPF000101.00infobox
Basic helix–loop–helixPROSITEPDOC000381.00infobox
Basic helix–loop–helixSCOP21mdy / SCOPe / SUPFAM1.00infobox
Basic helix–loop–helixSMARTSM003531.00infobox
Basic helix–loop–helixSymbolbHLH1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Basic helix–loop–helix bring nearby vocabulary together. In this analysis, examples include Motif, Factors and Helix. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Basic helix–loop–helix
    • Motif
    • Factors
    • Helix
    • Α-helices
    • Dna
    • Loop
    • Acid
    • Amino
    • Residues
    • Structural
    • Transcription
    • Two
  • basic helix–loop–helix
    • Motif
    • Structural
    • Loop
    • One
    • Factors
    • General
    • Helix
    • Α-helices
    • Dna
    • Acid
    • Amino
    • Arnt
  • structural motif
    • Structural
    • Arnt
    • Protein
    • Also
    • Domain
    • Structure
    • Proteins
    • Dna
    • E-box
    • Acid
    • Amino
    • Cell
  • transcription factors
    • Transcription
    • One
    • Acid
    • Amino
    • Residues
    • Contain
    • Form
    • General
    • Often
    • Helix
    • Dna
    • Motif
  • basic
    • Motif
    • Factors
    • Helix
    • Dna
    • Loop
    • Acid
    • Amino
    • Residues
    • Structural
    • Transcription
    • General
    • Protein
  • human proteins with helix–loop–helix dna-binding domain
    • Motif
    • Structural
    • Loop
    • One
    • General
    • Α-helices
    • Arnt
    • Protein
    • Two
    • Al
    • Bound
    • Domain
  • dna
    • Residues
    • Al
    • Et
    • General
    • Short
    • Bind
    • Proteins
    • E-box
    • Motif
    • Factors
    • Cell
    • Transcription
  • loop
    • Motif
    • Structural
    • Α-helices
    • Arnt
    • Protein
    • Two
    • One
    • Pdoc00038
    • Proteins
    • Also
    • Bound
    • Domain

Connections between topic areas Semantic bridges

For Basic helix–loop–helix, one of the stronger structural bridges in this analysis connects Basic helix–loop–helix with Human proteins with helix–loop–helix DNA-binding domain. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Basic helix–loop–helix — Human proteins with helix–loop–helix DNA-binding domain · splits 50 ⟂ 99
Basic helix–loop–helix — Examples · splits 125 ⟂ 24
Basic helix–loop–helix — Overview · splits 137 ⟂ 12
Basic helix–loop–helix — Structure · splits 141 ⟂ 8
Basic helix–loop–helix — History · splits 146 ⟂ 3

Map overview Semantic statistics

Basic helix–loop–helix

Nodes149
Edges148
Triples12
Avg. degree1.99
Density0.013423
Components1

Source & methodology

TTTA analyzes the structure around Basic helix–loop–helix to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Examples & Human proteins with helix–loop–helix DNA-binding domain, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Basic helix–loop–helix · EN edition · Analysis: TopicsToTalkAbout

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