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Basic helix–loop–helix

A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.

History, Examples & Human proteins with helix–loop–helix DNA-binding domain

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Examples

MyoDMyf5Beta2/NeuroD1SclTal1
23 related topics

Human proteins with helix–loop–helix DNA-binding domain

AHRAHRRARNTARNT2ARNTL2
98 related topics

Structure

Α-helicesLoopDimericConsensus sequenceE-box
7 related topics

History

E-BoxNucleotide
2 related topics

Key facts & relationships

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AlphaFold
IPR001092 · PF00010
Available protein structures:
IPR001092 · PF00010
CDD
cd00083
InterPro
IPR001092
PDB
1a0a​, 1am9​, 1an2​, 1an4​, 1hlo​, 1mdy​, 1nkp​, 1nlw​, 1r05​, 1ukl​, 2ql2​ IPR001092 PF00010 (ECOD; PDBsum)
Pfam
PF00010

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Human proteins with helix–loop–helix DNA-binding domain

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Basic helix–loop–helix

Nodes149
Edges148
Triples12
Avg. degree1.99
Density0.013423
Components1

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Basic helix–loop–helix

Top relations

AlphaFold · 2
Basic helix–loop–helix → IPR001092, PF00010
Available protein structures: · 2
Basic helix–loop–helix → IPR001092, PF00010
CDD · 1
Basic helix–loop–helix → cd00083
InterPro · 1
Basic helix–loop–helix → IPR001092
PDB · 1
Basic helix–loop–helix → 1a0a​, 1am9​, 1an2​, 1an4​, 1hlo​, 1mdy​, 1nkp​, 1nlw​, 1r05​, 1ukl​, 2ql2​ IPR001092 PF00010 (ECOD; PDBsum)
Pfam · 1
Basic helix–loop–helix → PF00010
PROSITE · 1
Basic helix–loop–helix → PDOC00038
SCOP2 · 1
Basic helix–loop–helix → 1mdy / SCOPe / SUPFAM
SMART · 1
Basic helix–loop–helix → SM00353
Symbol · 1
Basic helix–loop–helix → bHLH

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Important terminology

bhlh transcription loop factors proteins basic dna motif helix one e-box arnt α-helices protein also bind general contain often called

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Basic helix–loop–helixAlphaFoldIPR0010921.00infobox
Basic helix–loop–helixAlphaFoldPF000101.00infobox
Basic helix–loop–helixAvailable protein structures:IPR0010921.00infobox
Basic helix–loop–helixAvailable protein structures:PF000101.00infobox
Basic helix–loop–helixCDDcd000831.00infobox
Basic helix–loop–helixInterProIPR0010921.00infobox
Basic helix–loop–helixPDB1a0a​, 1am9​, 1an2​, 1an4​, 1hlo​, 1mdy​, 1nkp​, 1nlw​, 1r05​, 1ukl​, 2ql2​ IPR001092 PF00010 (ECOD; PDBsum)1.00infobox
Basic helix–loop–helixPfamPF000101.00infobox
Basic helix–loop–helixPROSITEPDOC000381.00infobox
Basic helix–loop–helixSCOP21mdy / SCOPe / SUPFAM1.00infobox
Basic helix–loop–helixSMARTSM003531.00infobox
Basic helix–loop–helixSymbolbHLH1.00infobox

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