Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

E-box

An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues. Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG, is recognized and bound by transcription…

Research & Regions

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around E-box. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Discovery

Binding

Role in the circadian clock

Role of proteins which bind to E-boxes

Recent research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

E-box

Nodes126
Edges125
Triples123
Avg. degree1.98
Density0.015873
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

E-box

Top relations

related to Role in the circadian clock · 30
E-box → Allen, As, BHLHB2, BHLHB3, Biology, BMAL1/CLOCK, CRY1, DBP, DD, Department, Depending, DNA, Drosophila, E-box-regulated, E/E'BOX, Hao, Hardin, It, LD, Nr1d1
related to Discovery · 16
E-box → David Baltimore's, E-protein, E12, E2-2, E2-2Alt, E47, HEB, HeLa, In, ITF-2A, Susumu Tonegawa's, The E-box, These, They, Two, Walter Gilbert's
related to Binding · 14
E-box → Besides, BMAL1/CLOCK, BMAL1/NPAS2, CACGTG, CAGCTG, CTRR, Depending, DNA, The, The CT-Rich Regions, The E-box, These, This, Zn2
related to Recent research · 13
E-box → Although, BMAL1/CLOCK, E-boxes, F-box/Leucine, FBXL3, Furthermore, It, Medical School, Myc/Max, Nanjing University, Recent, Researchers, They
related to TCF3 (E47) · 13
E-box → CANNTG, CKII, DJ, E12, E2A, E47, In, Its, Many, MK2, PKA, Similar, These
related to MYC (c-Myc, an oncogene) · 9
E-box → Dimers, DNA, E12, E6, Expression, GGCCACGTGACC, HLH, In, MYC
related to MYOD1 (MyoD) · 9
E-box → CANNTG, MRF, MRF4, Myf5, Myf6, MyoD, Other, The, When MyoD
related to CLOCK-ARNTL complex · 7
E-box → BMAL1, CLOCK-BMAL1, DEC1, DEC2, Knowing, The CLOCK-ARNTL, They
related to MyoG (Myogenin) · 6
E-box → Decreased MyoG, HDAC-Dach2-myogenin, MyoD, MyoG, MyoG-E-Box, They
related to External links · 4
E-box → Elements, Medicine Medical Subject Headings, MeSH, National Library

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

transcription binding proteins gene found circadian bind expression dna genes clock myod sequence also enhancer e47 discovered protein factors bhlh

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
E-boxis aintegral part of the transcription-translation feedback loop that comprises the circadian clock0.90text
E-boxrelated to BindingThese0.60section
E-boxrelated to BindingThis0.60section
E-boxrelated to BindingThe0.60section
E-boxrelated to BindingBesides0.60section
E-boxrelated to BindingDNA0.60section
E-boxrelated to BindingDepending0.60section
E-boxrelated to BindingCAGCTG0.60section
E-boxrelated to BindingCACGTG0.60section
E-boxrelated to BindingThe E-box0.60section
E-boxrelated to BindingZn20.60section
E-boxrelated to BindingThe CT-Rich Regions0.60section

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.