Microphthalmia-associated transcription factor

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The LysRS-Ap4A-MITF signaling pathway

LysRS (MAPK) pathway FcεRI TRNA synthetase Serine

15 related topics

Phosphorylation

Phosphorylated MAPK/BRAF/ERK Receptor tyrosine kinase KIT GSK-3

13 related topics

Translational regulation

Translational regulation Glutamine ATF4 EIF2α EIF2B

9 related topics

Overview

Protein Gene Basic helix-loop-helix Leucine zipper Transcription factor

18 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: MITF, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor, COMMAD, melanocyte inducing transcription fact…
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4C7N
Band: 3p13 · 6 D3|6 45.05 cM
Bgee: retinal pigment epithelium · Skeletal muscle tissue of biceps brachii · right ventricle · glutes · myocardium
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 6 (mouse)

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Overview

Clinical significance

Mutations

Target genes

Microarray Microarray analysis techniques

The LysRS-Ap4A-MITF signaling pathway

LysRS KARS (gene)
(MAPK) pathway Mitogen-activated protein kinase
FcεRI FCER1
TRNA synthetase Aminoacyl tRNA synthetase
Serine
Diadenosine tetraphosphate (Ap4A) Ap4A
ATP Adenosine triphosphate
T-cell T cell
Melanoma-associated antigen
Neuropathies Peripheral neuropathy
Nudix Nudix hydrolase
Importin-β Importin
Isoproterenol Isoprenaline
Hypertrophy
Cardiomyocytes Cardiac muscle cell

Phosphorylation

Phosphorylated Protein phosphorylation
MAPK/BRAF/ERK MAPK/ERK pathway
Receptor tyrosine kinase
KIT CD117
GSK-3
MTOR
Kinases Kinase
PI3K Phosphoinositide 3-kinase
AKT Protein kinase B
SRC protein family Src family kinase
P38 P38 mitogen-activated protein kinases
Pathway Signal transduction
D816V Point mutation

Interactions

Translational regulation

Translational regulation
Glutamine
ATF4
EIF2α EIF2A
EIF2B EIF2B2
DDX3X
5' UTR Five prime untranslated region
IRES Internal ribosome entry site
Cis-regulatory sequences Cis-regulatory element

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Map overview Semantic statistics

Microphthalmia-associated transcription factor

Nodes71

Edges70

Triples107

Avg. degree1.97

Density0.028169

Components1

How this topic connects Entity context

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Microphthalmia-associated transcription factor

Top relations

Gene ontology · 40

Microphthalmia-associated transcription factor → bone remodeling, camera-type eye development, canonical Wnt signaling pathway involved in negative regulation of apoptotic process, cell differentiation, cell fate commitment, chromatin binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, melanocyte differentiation, multicellular organism development, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus, osteoclast differentiation

Bgee · 18

Microphthalmia-associated transcription factor → atrioventricular valve, ciliary body, decidua, deltoid muscle, Epithelium of choroid plexus, gastrula, glutes, iris, myocardium, myocardium of left ventricle, pineal gland, retinal pigment epithelium, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, stria vascularis, urethra, vastus lateralis muscle

RNA expression pattern · 18

Band · 2

Microphthalmia-associated transcription factor → 3p13, 6 D3|6 45.05 cM

Chr. · 2

Microphthalmia-associated transcription factor → Chromosome 3 (human), Chromosome 6 (mouse)

End · 2

Microphthalmia-associated transcription factor → 69,968,336 bp, 97,998,310 bp

Aliases · 1

Microphthalmia-associated transcription factor → MITF, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor, COMMAD, melanocyte inducing transcription fact…

Available structures · 1

Microphthalmia-associated transcription factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4C7N

BioGPS · 1

Microphthalmia-associated transcription factor → More reference expression data

Databases · 1

Microphthalmia-associated transcription factor → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

mitf transcription gene factor protein also pathway melanoma genes mutations melanocytes cells activity expression cell human regulation signaling factors function

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Microphthalmia-associated transcription factor	Aliases	MITF, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor, COMMAD, melanocyte inducing transcription fact…	1.00	infobox
Microphthalmia-associated transcription factor	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4C7N	1.00	infobox
Microphthalmia-associated transcription factor	Band	3p13	1.00	infobox
Microphthalmia-associated transcription factor	Band	6 D3\|6 45.05 cM	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	retinal pigment epithelium	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	Skeletal muscle tissue of biceps brachii	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	right ventricle	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	glutes	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	myocardium	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	Skeletal muscle tissue of rectus abdominis	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	vastus lateralis muscle	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	myocardium of left ventricle	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	deltoid muscle	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	urethra	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	pineal gland	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	gastrula	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	decidua	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	iris	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	ciliary body	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	Epithelium of choroid plexus	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	stria vascularis	1.00	infobox
Microphthalmia-associated transcription factor	Bgee	atrioventricular valve	1.00	infobox
Microphthalmia-associated transcription factor	BioGPS	More reference expression data	1.00	infobox
Microphthalmia-associated transcription factor	Chr.	Chromosome 3 (human)	1.00	infobox
Microphthalmia-associated transcription factor	Chr.	Chromosome 6 (mouse)	1.00	infobox
Microphthalmia-associated transcription factor	Databases	NCBI: entry; OMA: entry	1.00	infobox
Microphthalmia-associated transcription factor	End	69,968,336 bp	1.00	infobox
Microphthalmia-associated transcription factor	End	97,998,310 bp	1.00	infobox
Microphthalmia-associated transcription factor	Ensembl	ENSG00000187098	1.00	infobox
Microphthalmia-associated transcription factor	Entrez	4286	1.00	infobox

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