Hypoxia-inducible factor

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Explore the main themes, entities and connections around Hypoxia-inducible factor. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Mechanism

Hydroxylated Proline HIF prolyl-hydroxylases Ubiquitination VHL

26 related topics

As a therapeutic target

HIF prolyl-hydroxylase inhibitor Roxadustat Vadadustat Daprodustat Desidustat

21 related topics

Function

Haematopoietic stem cells Stem cells Differentiating Formation of blood vessels Vascular system

12 related topics

Structure

Highly conserved Heterodimer Subunit Aryl hydrocarbon receptor nuclear translocator Per-ARNT-Sim

9 related topics

Key facts & relationships

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Domains: InterPro
HGNC: 4910
Locus: Chr. 14 q21-q24
NCBI gene: 3091
OMIM: 603348
RefSeq: NM_001530

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Map overview Semantic statistics

Nodes85

Edges84

Triples33

Avg. degree1.98

Density0.023529

Components1

How this topic connects Entity context

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Hypoxia-inducible factor

Top relations

related to External links · 14

Hypoxia-inducible factor → ARNT Complex, Factor, Heterodimeric HIF-1a, HRE DNA, Human Aryl, Human Endothelial PAS, Human Hypoxia-inducible, Hypoxia-Inducible, KB, Medicine Medical Subject Headings, MeSH, National Library, PDB, PDBe-KB

related to von Hippel–Lindau disease-associated renal cell carcinoma · 3

Hypoxia-inducible factor → Belzutifan, Hippel, Lindau

Domains · 1

Hypoxia-inducible factor → InterPro

HGNC · 1

Hypoxia-inducible factor → 4910

Locus · 1

Hypoxia-inducible factor → Chr. 14 q21-q24

NCBI gene · 1

Hypoxia-inducible factor → 3091

OMIM · 1

Hypoxia-inducible factor → 603348

RefSeq · 1

Hypoxia-inducible factor → NM_001530

Search for · 1

Hypoxia-inducible factor → Search forStructuresSwiss-modelDomainsInterPro

Structures · 1

Hypoxia-inducible factor → Swiss-model

Important terminology Word statistics

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Important terminology

hif hif-1 hypoxia oxygen conditions factor also nf-κb pseudohypoxia treatment shown prolyl-hydroxylase hif-1α hif-1a hypoxia-inducible factors transcription cancer anemia transcriptional

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Hypoxia-inducible factor	Domains	InterPro	1.00	infobox
Hypoxia-inducible factor	HGNC	4910	1.00	infobox
Hypoxia-inducible factor	Locus	Chr. 14 q21-q24	1.00	infobox
Hypoxia-inducible factor	NCBI gene	3091	1.00	infobox
Hypoxia-inducible factor	OMIM	603348	1.00	infobox
Hypoxia-inducible factor	RefSeq	NM_001530	1.00	infobox
Hypoxia-inducible factor	Search for	Search forStructuresSwiss-modelDomainsInterPro	1.00	infobox
Hypoxia-inducible factor	Structures	Swiss-model	1.00	infobox
Hypoxia-inducible factor	Symbol	HIF1A	1.00	infobox
Hypoxia-inducible factor	UniProt	Q16665	1.00	infobox
phenethyl isothiocyanate	instance of	so HIF inhibitors	0.80	text
Acriflavine	instance of	so HIF inhibitors	0.80	text

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