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HES1

Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.

Regions, HES1 and stem cells & Interactions

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Aliases
HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH3
Band
3q29 · 16 B2|16 21.09 cM
Bgee
renal medulla · ventricular zone · nipple · mucosa of pharynx · urethra
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Overview

Structure

Interactions

HES1 and stem cells

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Map overview Semantic statistics

HES1

Nodes56
Edges55
Triples267
Avg. degree1.96
Density0.035714
Components1

How this topic connects Entity context

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HES1

Top relations

Gene ontology · 110
HES1 → adenohypophysis development, anterior/posterior pattern specification, aorta morphogenesis, artery morphogenesis, ascending aorta morphogenesis, auditory receptor cell fate determination, cardiac neural crest cell development involved in outflow tract morphogenesis, cell adhesion, cell differentiation, cell fate commitment, cell maturation, cell migration, cell morphogenesis involved in neuron differentiation, chaperone binding, cochlea development, comma-shaped body morphogenesis, common bile duct development, cytoplasm, DNA binding, DNA-binding transcription factor activity
related to Neural development · 31
HES1 → Additionally, After, Brachyury, By, Contrariwise, Cycling HES1, Demethylation, Dll1, DNA, Epigenetic, Fgf5, HES, HES1's, HES1-high, HES1-low, Hes3, Hes5, In HES1, Indeed, KO
related to Interactions · 20
HES1 → Ascl1, Because Groucho, DNA, Drosophila, E47, Grg, Groucho-related, HES, Hes-Groucho, Hey1, Hey2, Mash1, Mash1-Hes, Similarly, Sirtuin, Tcfe2a, The E47-Hes, TLE, TLE2, Transducin-like
Bgee · 19
HES1 → bile duct, body of tongue, ciliary body, embryo, Eustachian tube, hair follicle, lip, middle ear, mucosa of pharynx, nipple, pericardium, pylorus, renal medulla, saphenous vein, tail of embryo, transitional epithelium of urinary bladder, urethra, vena cava, ventricular zone
RNA expression pattern · 19
HES1 → bile duct, body of tongue, ciliary body, embryo, Eustachian tube, hair follicle, lip, middle ear, mucosa of pharynx, nipple, pericardium, pylorus, renal medulla, saphenous vein, tail of embryo, transitional epithelium of urinary bladder, urethra, vena cava, ventricular zone
related to Digestive system · 14
HES1 → Alagille, Hes-Notch, In, Jagged1, Langerhans, Liver, Math1, Ngn3, Paneth, Ptf1a, The, Therefore, This, When Hes1
related to Interactions with the Notch pathway · 13
HES1 → After Notch, Deletion, Dll1, Hyperactivated Notch, In, Jag1, Jagged1, Neurogenin-2, Notch, Paneth, RBPJ, Rbpsuh, The
related to External links · 6
HES1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
HES1 → 16 B2|16 21.09 cM, 3q29
Chr. · 2
HES1 → Chromosome 16 (mouse), Chromosome 3 (human)

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Important terminology

cells expression genes transcription differentiation bhlh hes protein neural notch stem cell gene bp human also chr family band domain

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HES1AliasesHES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 11.00infobox
HES1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH31.00infobox
HES1Band3q291.00infobox
HES1Band16 B2|16 21.09 cM1.00infobox
HES1Bgeerenal medulla1.00infobox
HES1Bgeeventricular zone1.00infobox
HES1Bgeenipple1.00infobox
HES1Bgeemucosa of pharynx1.00infobox
HES1Bgeeurethra1.00infobox
HES1Bgeesaphenous vein1.00infobox
HES1Bgeepylorus1.00infobox
HES1Bgeepericardium1.00infobox
HES1Bgeevena cava1.00infobox
HES1Bgeebody of tongue1.00infobox
HES1Bgeelip1.00infobox
HES1Bgeetransitional epithelium of urinary bladder1.00infobox
HES1Bgeemiddle ear1.00infobox
HES1Bgeeciliary body1.00infobox
HES1Bgeeembryo1.00infobox
HES1Bgeetail of embryo1.00infobox
HES1BgeeEustachian tube1.00infobox
HES1Bgeebile duct1.00infobox
HES1Bgeehair follicle1.00infobox
HES1BioGPSMore reference expression data1.00infobox
HES1Chr.Chromosome 3 (human)1.00infobox
HES1Chr.Chromosome 16 (mouse)1.00infobox
HES1DatabasesNCBI: entry; OMA: entry1.00infobox
HES1End194,138,732 bp1.00infobox
HES1End29,886,614 bp1.00infobox
HES1EnsemblENSG000001143151.00infobox

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