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Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.
The analysis highlights Regions, HES1 and stem cells and Interactions as prominent areas in the source structure around HES1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around HES1 shows recurring relationship patterns in the source. For example, HES1 → adenohypophysis development, anterior/posterior pattern specification, aorta morphogenesis, artery morphogenesis, ascending aorta morphogenesis, auditory receptor cell fate determination, cardiac neural crest cell development involved in outflow tract morphogenesis, cell adhesion, cell differentiation, cell fate commitment, cell maturation, cell migration, cell morphogenesis involved in neuron differentiation, chaperone binding, cochlea development, comma-shaped body morphogenesis, common bile duct development, cytoplasm, DNA binding, DNA-binding transcription factor activity Another extracted example is HES1 → Additionally, After, Brachyury, By, Contrariwise, Cycling HES1, Demethylation, Dll1, DNA, Epigenetic, Fgf5, HES, HES1's, HES1-high, HES1-low, Hes3, Hes5, In HES1, Indeed, KO. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cells expression genes transcription differentiation bhlh hes protein neural notch stem cell gene bp human also chr family band domain
TTTA extracted 267 structured relationships around HES1. Examples in this analysis include HES1 → Aliases → HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1 and HES1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH3. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| HES1 | Aliases | HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1 | 1.00 | infobox |
| HES1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH3 | 1.00 | infobox |
| HES1 | Band | 3q29 | 1.00 | infobox |
| HES1 | Band | 16 B2|16 21.09 cM | 1.00 | infobox |
| HES1 | Bgee | renal medulla | 1.00 | infobox |
| HES1 | Bgee | ventricular zone | 1.00 | infobox |
| HES1 | Bgee | nipple | 1.00 | infobox |
| HES1 | Bgee | mucosa of pharynx | 1.00 | infobox |
| HES1 | Bgee | urethra | 1.00 | infobox |
| HES1 | Bgee | saphenous vein | 1.00 | infobox |
| HES1 | Bgee | pylorus | 1.00 | infobox |
| HES1 | Bgee | pericardium | 1.00 | infobox |
| HES1 | Bgee | vena cava | 1.00 | infobox |
| HES1 | Bgee | body of tongue | 1.00 | infobox |
| HES1 | Bgee | lip | 1.00 | infobox |
| HES1 | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| HES1 | Bgee | middle ear | 1.00 | infobox |
| HES1 | Bgee | ciliary body | 1.00 | infobox |
| HES1 | Bgee | embryo | 1.00 | infobox |
| HES1 | Bgee | tail of embryo | 1.00 | infobox |
| HES1 | Bgee | Eustachian tube | 1.00 | infobox |
| HES1 | Bgee | bile duct | 1.00 | infobox |
| HES1 | Bgee | hair follicle | 1.00 | infobox |
| HES1 | BioGPS | More reference expression data | 1.00 | infobox |
| HES1 | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| HES1 | Chr. | Chromosome 16 (mouse) | 1.00 | infobox |
| HES1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| HES1 | End | 194,138,732 bp | 1.00 | infobox |
| HES1 | End | 29,886,614 bp | 1.00 | infobox |
| HES1 | Ensembl | ENSG00000114315 | 1.00 | infobox |
The concept neighborhoods around HES1 bring nearby vocabulary together. In this analysis, examples include Cells, Expression and Stem. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For HES1, one of the stronger structural bridges in this analysis connects HES1 with HES1 and stem cells. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around HES1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, HES1 and stem cells & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — HES1 · EN edition · Analysis: TopicsToTalkAbout