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HES1: Regions, HES1 and stem cells & Interactions

Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.

Language: English [EN]
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HES1 topic overview

The analysis highlights Regions, HES1 and stem cells and Interactions as prominent areas in the source structure around HES1.

Related topics
51
Source areas
4
Connected nodes
55
Extracted relationships
267
Concept neighborhoods
21
Bridge connections
55

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

HES1 and stem cells · 32 topics
Overview · 8 topics
Interactions · 6 topics
Structure · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH3
Band
3q29 · 16 B2|16 21.09 cM
Bgee
renal medulla · ventricular zone · nipple · mucosa of pharynx · urethra
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Interactions

HES1 and stem cells

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HES1 connects Entity context

The extracted context around HES1 shows recurring relationship patterns in the source. For example, HES1 → adenohypophysis development, anterior/posterior pattern specification, aorta morphogenesis, artery morphogenesis, ascending aorta morphogenesis, auditory receptor cell fate determination, cardiac neural crest cell development involved in outflow tract morphogenesis, cell adhesion, cell differentiation, cell fate commitment, cell maturation, cell migration, cell morphogenesis involved in neuron differentiation, chaperone binding, cochlea development, comma-shaped body morphogenesis, common bile duct development, cytoplasm, DNA binding, DNA-binding transcription factor activity Another extracted example is HES1 → Additionally, After, Brachyury, By, Contrariwise, Cycling HES1, Demethylation, Dll1, DNA, Epigenetic, Fgf5, HES, HES1's, HES1-high, HES1-low, Hes3, Hes5, In HES1, Indeed, KO. Use these groups to spot repeated connection types before inspecting the individual relationships.

HES1

Top relations

Gene ontology · 110
HES1 → adenohypophysis development, anterior/posterior pattern specification, aorta morphogenesis, artery morphogenesis, ascending aorta morphogenesis, auditory receptor cell fate determination, cardiac neural crest cell development involved in outflow tract morphogenesis, cell adhesion, cell differentiation, cell fate commitment, cell maturation, cell migration, cell morphogenesis involved in neuron differentiation, chaperone binding, cochlea development, comma-shaped body morphogenesis, common bile duct development, cytoplasm, DNA binding, DNA-binding transcription factor activity
related to Neural development · 31
HES1 → Additionally, After, Brachyury, By, Contrariwise, Cycling HES1, Demethylation, Dll1, DNA, Epigenetic, Fgf5, HES, HES1's, HES1-high, HES1-low, Hes3, Hes5, In HES1, Indeed, KO
related to Interactions · 20
HES1 → Ascl1, Because Groucho, DNA, Drosophila, E47, Grg, Groucho-related, HES, Hes-Groucho, Hey1, Hey2, Mash1, Mash1-Hes, Similarly, Sirtuin, Tcfe2a, The E47-Hes, TLE, TLE2, Transducin-like
Bgee · 19
HES1 → bile duct, body of tongue, ciliary body, embryo, Eustachian tube, hair follicle, lip, middle ear, mucosa of pharynx, nipple, pericardium, pylorus, renal medulla, saphenous vein, tail of embryo, transitional epithelium of urinary bladder, urethra, vena cava, ventricular zone
RNA expression pattern · 19
HES1 → bile duct, body of tongue, ciliary body, embryo, Eustachian tube, hair follicle, lip, middle ear, mucosa of pharynx, nipple, pericardium, pylorus, renal medulla, saphenous vein, tail of embryo, transitional epithelium of urinary bladder, urethra, vena cava, ventricular zone
related to Digestive system · 14
HES1 → Alagille, Hes-Notch, In, Jagged1, Langerhans, Liver, Math1, Ngn3, Paneth, Ptf1a, The, Therefore, This, When Hes1
related to Interactions with the Notch pathway · 13
HES1 → After Notch, Deletion, Dll1, Hyperactivated Notch, In, Jag1, Jagged1, Neurogenin-2, Notch, Paneth, RBPJ, Rbpsuh, The
related to External links · 6
HES1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
HES1 → 16 B2|16 21.09 cM, 3q29
Chr. · 2
HES1 → Chromosome 16 (mouse), Chromosome 3 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells expression genes transcription differentiation bhlh hes protein neural notch stem cell gene bp human also chr family band domain

HES1 relationships Subject–Predicate–Object triples

TTTA extracted 267 structured relationships around HES1. Examples in this analysis include HES1 → Aliases → HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1 and HES1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HES1AliasesHES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 11.00infobox
HES1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MH31.00infobox
HES1Band3q291.00infobox
HES1Band16 B2|16 21.09 cM1.00infobox
HES1Bgeerenal medulla1.00infobox
HES1Bgeeventricular zone1.00infobox
HES1Bgeenipple1.00infobox
HES1Bgeemucosa of pharynx1.00infobox
HES1Bgeeurethra1.00infobox
HES1Bgeesaphenous vein1.00infobox
HES1Bgeepylorus1.00infobox
HES1Bgeepericardium1.00infobox
HES1Bgeevena cava1.00infobox
HES1Bgeebody of tongue1.00infobox
HES1Bgeelip1.00infobox
HES1Bgeetransitional epithelium of urinary bladder1.00infobox
HES1Bgeemiddle ear1.00infobox
HES1Bgeeciliary body1.00infobox
HES1Bgeeembryo1.00infobox
HES1Bgeetail of embryo1.00infobox
HES1BgeeEustachian tube1.00infobox
HES1Bgeebile duct1.00infobox
HES1Bgeehair follicle1.00infobox
HES1BioGPSMore reference expression data1.00infobox
HES1Chr.Chromosome 3 (human)1.00infobox
HES1Chr.Chromosome 16 (mouse)1.00infobox
HES1DatabasesNCBI: entry; OMA: entry1.00infobox
HES1End194,138,732 bp1.00infobox
HES1End29,886,614 bp1.00infobox
HES1EnsemblENSG000001143151.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HES1 bring nearby vocabulary together. In this analysis, examples include Cells, Expression and Stem. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HES1
    • Cells
    • Expression
    • Stem
    • Neural
    • Differentiation
    • Notch
    • Progenitor
    • Shown
    • Gene
    • Signaling
    • Cell
    • Genes
  • hes1
    • Cells
    • Expression
    • Stem
    • Neural
    • Differentiation
    • Notch
    • Progenitor
    • Shown
    • Gene
    • Signaling
    • Cell
    • Genes
  • protein
    • Transcription
    • Basic
    • Repressor
    • Bhlh
    • Human
    • Region
    • Domain
    • Gene
    • Cell
    • Genes
    • Band
    • Chromosome
  • gene
    • Chromosome
    • Bp
    • Chr
    • Human
    • Hes
    • Band
    • Drosophila
    • Family
    • System
    • Transcription
    • Pathway
    • Protein
  • transcription factors
    • Bhlh
    • Protein
    • Factor
    • Region
    • Hes
    • Gene
    • Genes
    • Repressor
    • Chromosome
    • Drosophila
    • Family
    • Proteins
  • orange domain
    • Region
    • Protein
    • Cell
    • Transcription
    • Notch
    • Factor
    • Repressor
    • Band
    • Chromosome
    • Nervous
    • System
    • Binding
  • stem cells
    • Neural
    • Stem
    • Hes1
    • Differentiation
    • Progenitor
    • Types
    • Fate
    • Notch
    • Expression
    • System
    • Binding
    • Human
  • progenitor cells
    • Neural
    • Stem
    • Hes1
    • Differentiation
    • Progenitor
    • Types
    • Notch
    • Expression
    • Genes
    • Levels
    • Shown
    • Fate

Connections between topic areas Semantic bridges

For HES1, one of the stronger structural bridges in this analysis connects HES1 with HES1 and stem cells. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HES1HES1 and stem cells · splits 23 ⟂ 33
HES1Overview · splits 47 ⟂ 9
HES1Interactions · splits 49 ⟂ 7
HES1Structure · splits 50 ⟂ 6

Map overview Semantic statistics

HES1

Nodes56
Edges55
Triples267
Avg. degree1.96
Density0.035714
Components1

Source & methodology

TTTA analyzes the structure around HES1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, HES1 and stem cells & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HES1 · EN edition · Analysis: TopicsToTalkAbout

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