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N-Myc: Interactions, Function & Clinical significance

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

Language: English [EN]
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N-Myc topic overview

The analysis highlights Interactions, Function and Clinical significance as prominent areas in the source structure around N-Myc.

Related topics
10
Source areas
4
Connected nodes
14
Extracted relationships
122
Concept neighborhoods
8
Bridge connections
14

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 4 topics
Function · 3 topics
Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYC…
Band
2p24.3 · 12 A1.1|12 6.14 cM
Bgee
ventricular zone · embryo · ganglionic eminence · gonad · placenta
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 12 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How N-Myc connects Entity context

The extracted context around N-Myc shows recurring relationship patterns in the source. For example, N-Myc → branching morphogenesis of an epithelial tube, cartilage condensation, chromatin, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic digit morphogenesis, embryonic skeletal system morphogenesis, kinase binding, lung development, negative regulation of astrocyte differentiation, negative regulation of gene expression, negative regulation of reactive oxygen species metabolic process, nucleolus, nucleus, positive regulation of cell death, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of mesenchymal cell proliferation Another extracted example is N-Myc → abdominal wall, Brodmann area 23, decidua, embryo, epiblast, ganglionic eminence, gonad, hair follicle, kidney tubule, mandibular prominence, maxillary prominence, medial ganglionic eminence, middle temporal gyrus, placenta, primitive streak, somite, superior cervical ganglion, testicle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

N-Myc

Top relations

Gene ontology · 31
N-Myc → branching morphogenesis of an epithelial tube, cartilage condensation, chromatin, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic digit morphogenesis, embryonic skeletal system morphogenesis, kinase binding, lung development, negative regulation of astrocyte differentiation, negative regulation of gene expression, negative regulation of reactive oxygen species metabolic process, nucleolus, nucleus, positive regulation of cell death, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of mesenchymal cell proliferation
Bgee · 19
N-Myc → abdominal wall, Brodmann area 23, decidua, embryo, epiblast, ganglionic eminence, gonad, hair follicle, kidney tubule, mandibular prominence, maxillary prominence, medial ganglionic eminence, middle temporal gyrus, placenta, primitive streak, somite, superior cervical ganglion, testicle, ventricular zone
RNA expression pattern · 19
N-Myc → abdominal wall, Brodmann area 23, decidua, embryo, epiblast, ganglionic eminence, gonad, hair follicle, kidney tubule, mandibular prominence, maxillary prominence, medial ganglionic eminence, middle temporal gyrus, placenta, primitive streak, somite, superior cervical ganglion, testicle, ventricular zone
related to Function · 15
N-Myc → DNA, GSK3b, It, MYC, MYCN, MYCN/NCYM, MYCNOS, N-cym, NCYM, RNA, The MYCN, This, This NCYM, Thus NCYM, Transgenic
related to Clinical significance · 14
N-Myc → Amplification, CCND1, Excess N-Myc, H3K27ac, Interestingly, Intriguingly, MYCN, MYCN-amplified, NB, NBs, Schwann, SE-driven, SEs, Three
related to Interactions · 4
N-Myc → Aurora, Conformational, Drugs, MAX
Band · 2
N-Myc → 12 A1.1|12 6.14 cM, 2p24.3
Chr. · 2
N-Myc → Chromosome 12 (mouse), Chromosome 2 (human)
End · 2
N-Myc → 12,991,915 bp, 15,947,007 bp
Aliases · 1
N-Myc → MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYC…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mycn gene human protein bp chr band also chromosome transcription cell development location function bhlh ncym mouse neuroblastoma rna dna

N-Myc relationships Subject–Predicate–Object triples

TTTA extracted 122 structured relationships around N-Myc. Examples in this analysis include N-Myc → Aliases → MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYC… and N-Myc → Band → 2p24.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
N-MycAliasesMYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYC…1.00infobox
N-MycBand2p24.31.00infobox
N-MycBand12 A1.1|12 6.14 cM1.00infobox
N-MycBgeeventricular zone1.00infobox
N-MycBgeeembryo1.00infobox
N-MycBgeeganglionic eminence1.00infobox
N-MycBgeegonad1.00infobox
N-MycBgeeplacenta1.00infobox
N-MycBgeekidney tubule1.00infobox
N-MycBgeetesticle1.00infobox
N-MycBgeemiddle temporal gyrus1.00infobox
N-MycBgeedecidua1.00infobox
N-MycBgeeBrodmann area 231.00infobox
N-MycBgeeprimitive streak1.00infobox
N-MycBgeeepiblast1.00infobox
N-MycBgeehair follicle1.00infobox
N-MycBgeemedial ganglionic eminence1.00infobox
N-MycBgeesomite1.00infobox
N-MycBgeeabdominal wall1.00infobox
N-MycBgeemandibular prominence1.00infobox
N-MycBgeemaxillary prominence1.00infobox
N-MycBgeesuperior cervical ganglion1.00infobox
N-MycBioGPSMore reference expression data1.00infobox
N-MycChr.Chromosome 2 (human)1.00infobox
N-MycChr.Chromosome 12 (mouse)1.00infobox
N-MycDatabasesNCBI: entry; OMA: entry1.00infobox
N-MycEnd15,947,007 bp1.00infobox
N-MycEnd12,991,915 bp1.00infobox
N-MycEnsemblENSG000001343231.00infobox
N-MycEntrez46131.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around N-Myc bring nearby vocabulary together. In this analysis, examples include Also, Bhlhe37 and Proto-oncogene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Function
    • Location
    • Chromosome
    • Bp
    • Chr
    • A1
    • End
    • Factor
    • Helix-loop-helix
    • Human
    • Mouse
    • Mycn
  • transcription factors
    • Factor
    • Bhlh
    • Dna
    • Function
    • Location
    • Neuroblastoma
    • Cell
    • Chromosome
    • Also
    • Bp
    • Chr
    • External
  • bhlh
    • Factor
    • Dna
    • Function
    • Location
    • Transcription
    • Cell
    • Chromosome
    • Bp
    • Chr
    • External
    • A1
    • Bhlhe37
  • function
    • Factor
    • Bhlh
    • Location
    • Transcription
    • Chromosome
    • Gene
    • Bp
    • Chr
    • A1
    • End
    • Helix-loop-helix
    • Human
  • N-Myc
    • Also
    • Bhlhe37
    • Proto-oncogene
    • Gene
    • Aurora
    • Normal
    • Development
    • External
    • Mycn
    • Basic
    • Factor
    • Helix-loop-helix
  • n-myc
    • Also
    • Bhlhe37
    • Proto-oncogene
    • Gene
    • Aurora
    • Normal
    • Development
    • External
    • Mycn
    • Basic
    • Factor
    • Helix-loop-helix
  • protein
    • Rna
    • Human
    • Bhlh
    • Dna
    • Cell
    • Ncym
    • A1
    • End
    • Factor
    • Mouse
    • Proto-oncogene
    • Binding
  • aurora a
    • Interaction
    • N-myc
    • Development

Connections between topic areas Semantic bridges

For N-Myc, one of the stronger structural bridges in this analysis connects N-Myc with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
N-MycInteractions · splits 10 ⟂ 5
N-MycFunction · splits 11 ⟂ 4
N-MycOverview · splits 12 ⟂ 3

Map overview Semantic statistics

N-Myc

Nodes15
Edges14
Triples122
Avg. degree1.87
Density0.133333
Components1

Source & methodology

TTTA analyzes the structure around N-Myc to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — N-Myc · EN edition · Analysis: TopicsToTalkAbout

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