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FIGLA: Function, Clinical significance & Overview

Folliculogenesis-specific basic helix-loop-helix, also known as factor in the germline alpha (FIGalpha) or transcription factor FIGa, is a protein that in humans is encoded by the FIGLA gene. The FIGLA gene is a germ cell-specific transcription factor preferentially expressed in oocytes that can be found on human chromosome 2p13.3.

Language: English [EN]
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FIGLA topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around FIGLA.

Related topics
7
Source areas
3
Connected nodes
10
Extracted relationships
84
Related term clusters
10
Bridge connections
10

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 4 topics
Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FIGLA, BHLHC8, FIGALPHA, POF6, folliculogenesis specific bHLH transcription factor
Band
2p13.3 · 6|6 C3
Bgee
oocyte · secondary oocyte · testicle · gonad · body of pancreas
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

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FIGLA
4Oocyte · Basic helix-loop-helix · Folliculogenesis
3Protein · Gene · Premature ovarian failure

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How FIGLA connects Entity context

The extracted context around FIGLA shows recurring relationship patterns in the source. For example, FIGLA → abdominal wall, body of pancreas, body of uterus, embryo, gastric mucosa, gonad, lens, myometrium, oocyte, ovarian follicle cell, primary follicle of ovary, primary oocyte, right ovary, secondary follicle of ovary, secondary oocyte, spermatid, spermatocyte, testicle, zygote Another extracted example is FIGLA → cell differentiation, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, multicellular organism development, nucleus, oocyte development, oogenesis, positive regulation of transcription by RNA polymerase II, protein dimerization activity, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription by RNA polymerase II, transcription factor binding, transcription regulator complex, transcription, DNA-templated. Use these groups to spot repeated connection types before inspecting the individual relationships.

FIGLA

Top relations

Bgee · 19
FIGLA → abdominal wall, body of pancreas, body of uterus, embryo, gastric mucosa, gonad, lens, myometrium, oocyte, ovarian follicle cell, primary follicle of ovary, primary oocyte, right ovary, secondary follicle of ovary, secondary oocyte, spermatid, spermatocyte, testicle, zygote
RNA expression pattern · 19
FIGLA → abdominal wall, body of pancreas, body of uterus, embryo, gastric mucosa, gonad, lens, myometrium, oocyte, ovarian follicle cell, primary follicle of ovary, primary oocyte, right ovary, secondary follicle of ovary, secondary oocyte, spermatid, spermatocyte, testicle, zygote
Gene ontology · 17
FIGLA → cell differentiation, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, multicellular organism development, nucleus, oocyte development, oogenesis, positive regulation of transcription by RNA polymerase II, protein dimerization activity, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcription by RNA polymerase II, transcription factor binding, transcription regulator complex, transcription, DNA-templated
related to Clinical significance · 6
FIGLA → Mutation, Premature, Women, Zp1, Zp2, ZP3
related to Function · 3
FIGLA → ZP1, ZP2, ZP3
Band · 2
FIGLA → 2p13.3, 6|6 C3
Chr. · 2
FIGLA → Chromosome 2 (human), Chromosome 6 (mouse)
End · 2
FIGLA → 70,790,643 bp, 85,997,978 bp
Aliases · 1
FIGLA → FIGLA, BHLHC8, FIGALPHA, POF6, folliculogenesis specific bHLH transcription factor
BioGPS · 1
FIGLA → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp factor transcription chromosome chr band protein ovarian failure location oocyte premature mouse expression figalpha expressed 2p13 function

FIGLA relationships Subject–Predicate–Object triples

TTTA extracted 84 structured relationships around FIGLA. Examples in this analysis include FIGLA → Aliases → FIGLA, BHLHC8, FIGALPHA, POF6, folliculogenesis specific bHLH transcription factor and FIGLA → Band → 2p13.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FIGLAAliasesFIGLA, BHLHC8, FIGALPHA, POF6, folliculogenesis specific bHLH transcription factor1.00infobox
FIGLABand2p13.31.00infobox
FIGLABand6|6 C31.00infobox
FIGLABgeeoocyte1.00infobox
FIGLABgeesecondary oocyte1.00infobox
FIGLABgeetesticle1.00infobox
FIGLABgeegonad1.00infobox
FIGLABgeebody of pancreas1.00infobox
FIGLABgeegastric mucosa1.00infobox
FIGLABgeemyometrium1.00infobox
FIGLABgeeabdominal wall1.00infobox
FIGLABgeebody of uterus1.00infobox
FIGLABgeeright ovary1.00infobox
FIGLABgeeprimary oocyte1.00infobox
FIGLABgeeembryo1.00infobox
FIGLABgeeovarian follicle cell1.00infobox
FIGLABgeesecondary follicle of ovary1.00infobox
FIGLABgeezygote1.00infobox
FIGLABgeelens1.00infobox
FIGLABgeeprimary follicle of ovary1.00infobox
FIGLABgeespermatid1.00infobox
FIGLABgeespermatocyte1.00infobox
FIGLABioGPSn/a1.00infobox
FIGLAChr.Chromosome 2 (human)1.00infobox
FIGLAChr.Chromosome 6 (mouse)1.00infobox
FIGLADatabasesNCBI: entry; OMA: entry1.00infobox
FIGLAEnd70,790,643 bp1.00infobox
FIGLAEnd85,997,978 bp1.00infobox
FIGLAEnsemblENSG000001837331.00infobox
FIGLAEntrez3440181.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around FIGLA bring nearby vocabulary together. In this analysis, examples include Gene, Ovarian and Transcription. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • FIGLA
    • Gene
    • Ovarian
    • Transcription
    • Premature
    • Chromosome
    • Failure
    • Human
    • Expressed
    • Function
    • Humans
    • Location
    • Oocyte
  • figla
    • Gene
    • Ovarian
    • Transcription
    • Premature
    • Chromosome
    • Failure
    • Human
    • Expressed
    • Function
    • Humans
    • Location
    • Oocyte
  • gene
    • Chromosome
    • Human
    • Transcription
    • Location
    • Bp
    • Chr
    • 2p13
    • End
    • Expressed
    • Function
    • Mouse
    • Protein
  • protein
    • Differentiation
    • Oocyte-specific
    • Transcription
    • Oocyte
    • End
    • Expressed
    • Expression
    • Folliculogenesis
    • Function
    • Humans
    • Mouse
    • Genes
  • basic helix-loop-helix
    • Helix-loop-helix
    • Protein
    • Factor
    • Transcription
    • Also
    • Differentiation
    • Figalpha
    • Folliculogenesis
    • Humans
    • Oocyte-specific
    • Genes
    • Oocyte
  • folliculogenesis
    • Transcription
    • Differentiation
    • Function
    • Helix-loop-helix
    • Oocyte-specific
    • Genes
    • Location
    • Oocyte
    • Pellucida
    • Protein
    • Zona
    • Bp
  • premature ovarian failure
    • Failure
    • Ovarian
    • Premature
    • Figla
    • Humans
    • Oocyte-specific
    • Zp1
    • Zp2
    • Zp3
    • Genes
    • Pellucida
    • Protein
  • function
    • Location
    • Bp
    • Chr
    • Human
    • Transcription
    • Differentiation
    • End
    • Expression
    • Gene
    • Mouse
    • Oocyte-specific
    • Oocyte

Connections between topic areas Semantic bridges

For FIGLA, one of the stronger structural bridges in this analysis connects FIGLA with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FIGLA — Function · splits 6 ⟂ 5
FIGLA — Overview · splits 8 ⟂ 3

Map overview Semantic statistics

FIGLA

Nodes11
Edges10
Triples84
Avg. degree1.82
Density0.181818
Components1

Source & methodology

TTTA analyzes the structure around FIGLA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FIGLA · EN edition · Analysis: TopicsToTalkAbout

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