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TFEB: Function & Overview

Transcription factor EB is a protein that in humans is encoded by the TFEB gene.

Language: English [EN]
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TFEB topic overview

The analysis highlights Function and Overview as prominent areas in the source structure around TFEB.

Related topics
25
Source areas
2
Connected nodes
27
Extracted relationships
90
Concept neighborhoods
13
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 23 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TFEB, ALPHABHLHE35, TCFEB, transcription factor EB
Band
6p21.1 · 17 C|17 23.99 cM
Bgee
muscle of thigh · gastrocnemius muscle · apex of heart · granulocyte · blood
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TFEB connects Entity context

The extracted context around TFEB shows recurring relationship patterns in the source. For example, TFEB → adaptive immune response, autophagy, cytoplasm, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic placenta development, humoral immune response, immune system process, lysosome localization, lysosome organization, nucleus, positive regulation of autophagy, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein dimerization activity, regulation of transcription, DNA-templated, transcription, DNA-templated Another extracted example is TFEB → ankle, apex of heart, blood, C1 segment, ciliary body, esophagus, gastrocnemius muscle, granulocyte, inferior ganglion of vagus nerve, inferior olivary nucleus, iris, monocyte, muscle of thigh, spleen, temporal muscle, triceps brachii muscle, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

TFEB

Top relations

Gene ontology · 18
TFEB → adaptive immune response, autophagy, cytoplasm, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic placenta development, humoral immune response, immune system process, lysosome localization, lysosome organization, nucleus, positive regulation of autophagy, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein dimerization activity, regulation of transcription, DNA-templated, transcription, DNA-templated
Bgee · 17
TFEB → ankle, apex of heart, blood, C1 segment, ciliary body, esophagus, gastrocnemius muscle, granulocyte, inferior ganglion of vagus nerve, inferior olivary nucleus, iris, monocyte, muscle of thigh, spleen, temporal muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 17
TFEB → ankle, apex of heart, blood, C1 segment, ciliary body, esophagus, gastrocnemius muscle, granulocyte, inferior ganglion of vagus nerve, inferior olivary nucleus, iris, monocyte, muscle of thigh, spleen, temporal muscle, triceps brachii muscle, vastus lateralis muscle
related to Function · 10
TFEB → Alzheimer's, Ca2, Huntington's, In, It, NAADP, Parkinson's, PGC1-alpha, Upon, Viral-mediated TFEB
Band · 2
TFEB → 17 C|17 23.99 cM, 6p21.1
Chr. · 2
TFEB → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
TFEB → 41,736,259 bp, 48,103,344 bp
Aliases · 1
TFEB → TFEB, ALPHABHLHE35, TCFEB, transcription factor EB
BioGPS · 1
TFEB → More reference expression data
Databases · 1
TFEB → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

lysosomal bp gene chr human band autophagy mouse transcription factor chromosome biogenesis protein location nuclear mtorc1 expression activity cellular eb

TFEB relationships Subject–Predicate–Object triples

TTTA extracted 90 structured relationships around TFEB. Examples in this analysis include TFEB → Aliases → TFEB, ALPHABHLHE35, TCFEB, transcription factor EB and TFEB → Band → 6p21.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TFEBAliasesTFEB, ALPHABHLHE35, TCFEB, transcription factor EB1.00infobox
TFEBBand6p21.11.00infobox
TFEBBand17 C|17 23.99 cM1.00infobox
TFEBBgeemuscle of thigh1.00infobox
TFEBBgeegastrocnemius muscle1.00infobox
TFEBBgeeapex of heart1.00infobox
TFEBBgeegranulocyte1.00infobox
TFEBBgeeblood1.00infobox
TFEBBgeeC1 segment1.00infobox
TFEBBgeeinferior olivary nucleus1.00infobox
TFEBBgeespleen1.00infobox
TFEBBgeeinferior ganglion of vagus nerve1.00infobox
TFEBBgeemonocyte1.00infobox
TFEBBgeeesophagus1.00infobox
TFEBBgeetriceps brachii muscle1.00infobox
TFEBBgeetemporal muscle1.00infobox
TFEBBgeevastus lateralis muscle1.00infobox
TFEBBgeeankle1.00infobox
TFEBBgeeiris1.00infobox
TFEBBgeeciliary body1.00infobox
TFEBBioGPSMore reference expression data1.00infobox
TFEBChr.Chromosome 6 (human)1.00infobox
TFEBChr.Chromosome 17 (mouse)1.00infobox
TFEBDatabasesNCBI: entry; OMA: entry1.00infobox
TFEBEnd41,736,259 bp1.00infobox
TFEBEnd48,103,344 bp1.00infobox
TFEBEnsemblENSG000001125611.00infobox
TFEBEntrez79421.00infobox
TFEBExternal IDsOMIM: 600744; MGI: 103270; GeneCards: TFEB1.00infobox
TFEBGene location (Human)Gene location (Human)Chr.Chromosome 6 (human)Band6p21.1Start41,683,978 bpEnd41,736,259 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TFEB bring nearby vocabulary together. In this analysis, examples include Lysosomal, Nuclear and Mouse. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TFEB
    • Lysosomal
    • Nuclear
    • Mouse
    • Activation
    • Activity
    • Akt
    • Disease
    • Overexpression
    • Pkb
    • Via
    • Biogenesis
    • Gene
  • tfeb
    • Lysosomal
    • Nuclear
    • Mouse
    • Activation
    • Activity
    • Akt
    • Disease
    • Overexpression
    • Pkb
    • Via
    • Biogenesis
    • Gene
  • autophagy
    • Biogenesis
    • Lysosomal
    • Cellular
    • Expression
    • Factor
    • Transcription
    • Mouse
    • Cytoplasm
    • End
    • Function
    • Nucleus
    • Tfeb
  • transcription factor
    • Factor
    • Transcription
    • Gene
    • Eb
    • Function
    • Expression
    • Location
    • Protein
    • Chromosome
    • Human
    • Autophagy
    • Bp
  • protein
    • Gene
    • Transcription
    • Cytoplasm
    • End
    • Function
    • Nucleus
    • Activity
    • Akt
    • Cellular
    • Expression
    • Location
    • Pkb
  • biogenesis
    • Cellular
    • Lysosomal
    • Mouse
    • Cytoplasm
    • End
    • Function
    • Nucleus
    • Akt
    • Disease
    • Expression
    • Location
    • Overexpression
  • gene
    • Location
    • Chromosome
    • Human
    • Transcription
    • Bp
    • Chr
    • End
    • Function
    • Protein
    • Band
    • Mouse
    • Cytoplasm
  • function
    • Location
    • Chromosome
    • Gene
    • Human
    • Transcription
    • Bp
    • Chr
    • Cytoplasm
    • End
    • Nucleus
    • Activity
    • Cellular

Connections between topic areas Semantic bridges

For TFEB, one of the stronger structural bridges in this analysis connects TFEB with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TFEBFunction · splits 4 ⟂ 24
TFEBOverview · splits 25 ⟂ 3

Map overview Semantic statistics

TFEB

Nodes28
Edges27
Triples90
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around TFEB to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TFEB · EN edition · Analysis: TopicsToTalkAbout

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