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EPAS1: Clinical significance, Function & Alleles

Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration. The gene is active under hypoxic conditions. It is…

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EPAS1 topic overview

The analysis highlights Clinical significance, Function and Alleles as prominent areas in the source structure around EPAS1.

Related topics
48
Source areas
5
Connected nodes
53
Extracted relationships
139
Concept neighborhoods
22
Bridge connections
53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 15 topics
Function · 14 topics
Overview · 11 topics
Alleles · 5 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2
Band
2p21 · 17|17 E4
Bgee
right lung · lower lobe of lung · nasal epithelium · placenta · visceral pleura
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Alleles

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EPAS1 connects Entity context

The extracted context around EPAS1 shows recurring relationship patterns in the source. For example, EPAS1 → angiogenesis, blood vessel remodeling, cell differentiation, cell maturation, cellular response to hypoxia, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic placenta development, erythrocyte differentiation, hemopoiesis, histone acetyltransferase binding, iron ion homeostasis, lung development, mitochondrion organization, multicellular organism development, myoblast fate commitment Another extracted example is EPAS1 → carotid body, ciliary body, decidua, digastric muscle, Epithelium of choroid plexus, gastrula, left lung lobe, lower lobe of lung, nasal epithelium, pericardium, placenta, retinal pigment epithelium, right lung, right lung lobe, saphenous vein, superficial temporal artery, upper lobe of left lung, upper lobe of lung, Vasculature of brain, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

EPAS1

Top relations

Gene ontology · 46
EPAS1 → angiogenesis, blood vessel remodeling, cell differentiation, cell maturation, cellular response to hypoxia, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic placenta development, erythrocyte differentiation, hemopoiesis, histone acetyltransferase binding, iron ion homeostasis, lung development, mitochondrion organization, multicellular organism development, myoblast fate commitment
Bgee · 20
EPAS1 → carotid body, ciliary body, decidua, digastric muscle, Epithelium of choroid plexus, gastrula, left lung lobe, lower lobe of lung, nasal epithelium, pericardium, placenta, retinal pigment epithelium, right lung, right lung lobe, saphenous vein, superficial temporal artery, upper lobe of left lung, upper lobe of lung, Vasculature of brain, visceral pleura
RNA expression pattern · 20
EPAS1 → carotid body, ciliary body, decidua, digastric muscle, Epithelium of choroid plexus, gastrula, left lung lobe, lower lobe of lung, nasal epithelium, pericardium, placenta, retinal pigment epithelium, right lung, right lung lobe, saphenous vein, superficial temporal artery, upper lobe of left lung, upper lobe of lung, Vasculature of brain, visceral pleura
related to Clinical significance · 9
EPAS1 → EPO, HIF-2α, Himalayas, In, Mutations, The, There, Tibet, Tibetans
related to Alleles · 6
EPAS1 → Denisovan, The, The EPAS1, The Himalayan, Tibetan Mastiff, Tibetans
related to External links · 6
EPAS1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Function · 5
EPAS1 → Catecholamine, Catecholamines, It, The, The EPAS1
Band · 2
EPAS1 → 17|17 E4, 2p21
Chr. · 2
EPAS1 → Chromosome 17 (mouse), Chromosome 2 (human)
End · 2
EPAS1 → 46,386,697 bp, 87,140,838 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp protein also heart chr band oxygen blood allele chromosome development hypoxia-inducible mutations hif-2α known catecholamine endothelial factor

EPAS1 relationships Subject–Predicate–Object triples

TTTA extracted 139 structured relationships around EPAS1. Examples in this analysis include EPAS1 → Aliases → EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha and EPAS1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EPAS1AliasesEPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha1.00infobox
EPAS1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT21.00infobox
EPAS1Band2p211.00infobox
EPAS1Band17|17 E41.00infobox
EPAS1Bgeeright lung1.00infobox
EPAS1Bgeelower lobe of lung1.00infobox
EPAS1Bgeenasal epithelium1.00infobox
EPAS1Bgeeplacenta1.00infobox
EPAS1Bgeevisceral pleura1.00infobox
EPAS1Bgeeupper lobe of lung1.00infobox
EPAS1Bgeeupper lobe of left lung1.00infobox
EPAS1Bgeesaphenous vein1.00infobox
EPAS1Bgeesuperficial temporal artery1.00infobox
EPAS1Bgeepericardium1.00infobox
EPAS1Bgeeright lung lobe1.00infobox
EPAS1Bgeegastrula1.00infobox
EPAS1BgeeVasculature of brain1.00infobox
EPAS1Bgeeretinal pigment epithelium1.00infobox
EPAS1Bgeecarotid body1.00infobox
EPAS1Bgeedecidua1.00infobox
EPAS1Bgeeleft lung lobe1.00infobox
EPAS1Bgeeciliary body1.00infobox
EPAS1BgeeEpithelium of choroid plexus1.00infobox
EPAS1Bgeedigastric muscle1.00infobox
EPAS1BioGPSMore reference expression data1.00infobox
EPAS1Chr.Chromosome 2 (human)1.00infobox
EPAS1Chr.Chromosome 17 (mouse)1.00infobox
EPAS1DatabasesNCBI: entry; OMA: entry1.00infobox
EPAS1End46,386,697 bp1.00infobox
EPAS1End87,140,838 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EPAS1 bring nearby vocabulary together. In this analysis, examples include Blood, Protein and Embryonic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EPAS1
    • Blood
    • Protein
    • Embryonic
    • Gene
    • Development
    • High
    • Heart
    • Human
    • Alleles
    • Cell
    • Hypoxia-inducible
    • Involved
  • epas1
    • Blood
    • Protein
    • Embryonic
    • Gene
    • Development
    • High
    • Heart
    • Human
    • Alleles
    • Cell
    • Hypoxia-inducible
    • Involved
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Protein
    • Human
    • Mouse
    • Hypoxia-inducible
    • Known
    • Band
    • Allele
    • Mutations
  • hypoxia-inducible factor
    • Transcription
    • Involved
    • Response
    • Mouse
    • Oxygen
    • Protein
    • Alleles
    • Cell
    • Embryonic
    • Factor
    • Hypoxia-inducible
    • Location
  • blood vessels
    • Cell
    • Embryonic
    • Involved
    • Development
    • Production
    • Sickness
    • Epas1
    • Heart
    • Oxygen
    • Factor
    • Mouse
    • Transcription
  • embryonic heart
    • Embryonic
    • Heart
    • Involved
    • Protection
    • Factor
    • Mouse
    • Production
    • Transcription
    • Blood
    • Endothelial
    • Location
    • Response
  • clear cell renal cell carcinoma
    • Blood
    • Factor
    • Mouse
    • Transcription
    • Embryonic
    • Involved
    • Location
    • Response
    • Chromosome
    • Development
    • Hif-2α
    • High
  • transcription factor
    • Factor
    • Transcription
    • Involved
    • Response
    • Mouse
    • Oxygen
    • Cell
    • Embryonic
    • Hypoxia-inducible
    • Location
    • Band
    • Chromosome

Connections between topic areas Semantic bridges

For EPAS1, one of the stronger structural bridges in this analysis connects EPAS1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EPAS1Clinical significance · splits 38 ⟂ 16
EPAS1Function · splits 39 ⟂ 15
EPAS1Overview · splits 42 ⟂ 12
EPAS1Alleles · splits 48 ⟂ 6
EPAS1Interactions · splits 50 ⟂ 4

Map overview Semantic statistics

EPAS1

Nodes54
Edges53
Triples139
Avg. degree1.96
Density0.037037
Components1

Source & methodology

TTTA analyzes the structure around EPAS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Alleles, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EPAS1 · EN edition · Analysis: TopicsToTalkAbout

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