EPAS1

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Clinical significance

Paragangliomas Somatostatinomas Pheochromocytomas Somatic Missense mutations

15 related topics

Function

Transcription factor Basic helix–loop–helix Signal transduction Embryonic heart Endothelial cells

14 related topics

Alleles

Tibetans Hybridization Himalayan wolf Tibetan Mastiff Ghost population

5 related topics

Interactions

Interact Aryl hydrocarbon receptor nuclear translocator ARNTL

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2
Band: 2p21 · 17|17 E4
Bgee: right lung · lower lobe of lung · nasal epithelium · placenta · visceral pleura
BioGPS: More reference expression data
Chr.: Chromosome 2 (human) · Chromosome 17 (mouse)

Topics to explore

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Overview

Protein
Gene
Hypoxia-inducible factor Hypoxia-inducible factors
Transcription factors
Hypoxic Hypoxia (environmental)
Catecholamine
Neuroendocrine tumors Neuroendocrine tumor
Alleles Allele
High-altitude adaptation in humans
Denisovan
Archaic hominins Archaic humans

Function

Advanced semantic analysis

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Map overview Semantic statistics

Nodes54

Edges53

Triples139

Avg. degree1.96

Density0.037037

Components1

How this topic connects Entity context

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EPAS1

Top relations

Gene ontology · 46

EPAS1 → angiogenesis, blood vessel remodeling, cell differentiation, cell maturation, cellular response to hypoxia, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic placenta development, erythrocyte differentiation, hemopoiesis, histone acetyltransferase binding, iron ion homeostasis, lung development, mitochondrion organization, multicellular organism development, myoblast fate commitment

Bgee · 20

EPAS1 → carotid body, ciliary body, decidua, digastric muscle, Epithelium of choroid plexus, gastrula, left lung lobe, lower lobe of lung, nasal epithelium, pericardium, placenta, retinal pigment epithelium, right lung, right lung lobe, saphenous vein, superficial temporal artery, upper lobe of left lung, upper lobe of lung, Vasculature of brain, visceral pleura

RNA expression pattern · 20

related to Clinical significance · 9

EPAS1 → EPO, HIF-2α, Himalayas, In, Mutations, The, There, Tibet, Tibetans

related to Alleles · 6

EPAS1 → Denisovan, The, The EPAS1, The Himalayan, Tibetan Mastiff, Tibetans

related to External links · 6

EPAS1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

related to Function · 5

EPAS1 → Catecholamine, Catecholamines, It, The, The EPAS1

Band · 2

EPAS1 → 17|17 E4, 2p21

Chr. · 2

EPAS1 → Chromosome 17 (mouse), Chromosome 2 (human)

End · 2

EPAS1 → 46,386,697 bp, 87,140,838 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp protein also heart chr band oxygen blood allele chromosome development hypoxia-inducible mutations hif-2α known catecholamine endothelial factor

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
EPAS1	Aliases	EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha	1.00	infobox
EPAS1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2	1.00	infobox
EPAS1	Band	2p21	1.00	infobox
EPAS1	Band	17\|17 E4	1.00	infobox
EPAS1	Bgee	right lung	1.00	infobox
EPAS1	Bgee	lower lobe of lung	1.00	infobox
EPAS1	Bgee	nasal epithelium	1.00	infobox
EPAS1	Bgee	placenta	1.00	infobox
EPAS1	Bgee	visceral pleura	1.00	infobox
EPAS1	Bgee	upper lobe of lung	1.00	infobox
EPAS1	Bgee	upper lobe of left lung	1.00	infobox
EPAS1	Bgee	saphenous vein	1.00	infobox
EPAS1	Bgee	superficial temporal artery	1.00	infobox
EPAS1	Bgee	pericardium	1.00	infobox
EPAS1	Bgee	right lung lobe	1.00	infobox
EPAS1	Bgee	gastrula	1.00	infobox
EPAS1	Bgee	Vasculature of brain	1.00	infobox
EPAS1	Bgee	retinal pigment epithelium	1.00	infobox
EPAS1	Bgee	carotid body	1.00	infobox
EPAS1	Bgee	decidua	1.00	infobox
EPAS1	Bgee	left lung lobe	1.00	infobox
EPAS1	Bgee	ciliary body	1.00	infobox
EPAS1	Bgee	Epithelium of choroid plexus	1.00	infobox
EPAS1	Bgee	digastric muscle	1.00	infobox
EPAS1	BioGPS	More reference expression data	1.00	infobox
EPAS1	Chr.	Chromosome 2 (human)	1.00	infobox
EPAS1	Chr.	Chromosome 17 (mouse)	1.00	infobox
EPAS1	Databases	NCBI: entry; OMA: entry	1.00	infobox
EPAS1	End	46,386,697 bp	1.00	infobox
EPAS1	End	87,140,838 bp	1.00	infobox

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