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Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration. The gene is active under hypoxic conditions. It is…
The analysis highlights Clinical significance, Function and Alleles as prominent areas in the source structure around EPAS1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around EPAS1 shows recurring relationship patterns in the source. For example, EPAS1 → angiogenesis, blood vessel remodeling, cell differentiation, cell maturation, cellular response to hypoxia, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic placenta development, erythrocyte differentiation, hemopoiesis, histone acetyltransferase binding, iron ion homeostasis, lung development, mitochondrion organization, multicellular organism development, myoblast fate commitment Another extracted example is EPAS1 → carotid body, ciliary body, decidua, digastric muscle, Epithelium of choroid plexus, gastrula, left lung lobe, lower lobe of lung, nasal epithelium, pericardium, placenta, retinal pigment epithelium, right lung, right lung lobe, saphenous vein, superficial temporal artery, upper lobe of left lung, upper lobe of lung, Vasculature of brain, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene human bp protein also heart chr band oxygen blood allele chromosome development hypoxia-inducible mutations hif-2α known catecholamine endothelial factor
TTTA extracted 139 structured relationships around EPAS1. Examples in this analysis include EPAS1 → Aliases → EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha and EPAS1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| EPAS1 | Aliases | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha | 1.00 | infobox |
| EPAS1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2 | 1.00 | infobox |
| EPAS1 | Band | 2p21 | 1.00 | infobox |
| EPAS1 | Band | 17|17 E4 | 1.00 | infobox |
| EPAS1 | Bgee | right lung | 1.00 | infobox |
| EPAS1 | Bgee | lower lobe of lung | 1.00 | infobox |
| EPAS1 | Bgee | nasal epithelium | 1.00 | infobox |
| EPAS1 | Bgee | placenta | 1.00 | infobox |
| EPAS1 | Bgee | visceral pleura | 1.00 | infobox |
| EPAS1 | Bgee | upper lobe of lung | 1.00 | infobox |
| EPAS1 | Bgee | upper lobe of left lung | 1.00 | infobox |
| EPAS1 | Bgee | saphenous vein | 1.00 | infobox |
| EPAS1 | Bgee | superficial temporal artery | 1.00 | infobox |
| EPAS1 | Bgee | pericardium | 1.00 | infobox |
| EPAS1 | Bgee | right lung lobe | 1.00 | infobox |
| EPAS1 | Bgee | gastrula | 1.00 | infobox |
| EPAS1 | Bgee | Vasculature of brain | 1.00 | infobox |
| EPAS1 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| EPAS1 | Bgee | carotid body | 1.00 | infobox |
| EPAS1 | Bgee | decidua | 1.00 | infobox |
| EPAS1 | Bgee | left lung lobe | 1.00 | infobox |
| EPAS1 | Bgee | ciliary body | 1.00 | infobox |
| EPAS1 | Bgee | Epithelium of choroid plexus | 1.00 | infobox |
| EPAS1 | Bgee | digastric muscle | 1.00 | infobox |
| EPAS1 | BioGPS | More reference expression data | 1.00 | infobox |
| EPAS1 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| EPAS1 | Chr. | Chromosome 17 (mouse) | 1.00 | infobox |
| EPAS1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| EPAS1 | End | 46,386,697 bp | 1.00 | infobox |
| EPAS1 | End | 87,140,838 bp | 1.00 | infobox |
The concept neighborhoods around EPAS1 bring nearby vocabulary together. In this analysis, examples include Blood, Protein and Embryonic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For EPAS1, one of the stronger structural bridges in this analysis connects EPAS1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around EPAS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Alleles, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — EPAS1 · EN edition · Analysis: TopicsToTalkAbout