Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are…
The analysis highlights History, Gene and Function as prominent areas in the source structure around Tumor necrosis factor.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Tumor necrosis factor shows recurring relationship patterns in the source. For example, Tumor necrosis factor → activation of cysteine-type endopeptidase activity involved in apoptotic process, animal organ morphogenesis, apoptotic signaling pathway, cell surface, cellular extravasation, cellular response to amino acid stimulus, cellular response to lipopolysaccharide, cellular response to nicotine, cellular response to organic cyclic compound, chronic inflammatory response to antigenic stimulus, cortical actin cytoskeleton organization, cytokine activity, cytokine-mediated signaling pathway, death-inducing signaling complex assembly, defense response, defense response to bacterium, defense response to Gram-positive bacterium, embryonic digestive tract development, endothelial cell apoptotic process, epithelial cell proliferation involved in salivary gland morphogenesis Another extracted example is Tumor necrosis factor → appendix, blood, bone marrow, bone marrow cell, duodenum, embryo, endometrium, granulocyte, lymph node, mesenteric lymph nodes, monocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus, wall of uterus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
tnf cell tnfr1 cells inflammatory tnfr2 death also tmtnf immune gene activation response complex nf-κb pathways pathway role tumor cytokines
TTTA extracted 250 structured relationships around Tumor necrosis factor. Examples in this analysis include Tumor necrosis factor → Aliases → TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha and Tumor necrosis factor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Tumor necrosis factor | Aliases | TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha | 1.00 | infobox |
| Tumor necrosis factor | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW | 1.00 | infobox |
| Tumor necrosis factor | Band | 6p21.33 | 1.00 | infobox |
| Tumor necrosis factor | Band | 17 B1|17 18.59 cM | 1.00 | infobox |
| Tumor necrosis factor | Bgee | granulocyte | 1.00 | infobox |
| Tumor necrosis factor | Bgee | testicle | 1.00 | infobox |
| Tumor necrosis factor | Bgee | bone marrow | 1.00 | infobox |
| Tumor necrosis factor | Bgee | monocyte | 1.00 | infobox |
| Tumor necrosis factor | Bgee | bone marrow cell | 1.00 | infobox |
| Tumor necrosis factor | Bgee | blood | 1.00 | infobox |
| Tumor necrosis factor | Bgee | lymph node | 1.00 | infobox |
| Tumor necrosis factor | Bgee | spleen | 1.00 | infobox |
| Tumor necrosis factor | Bgee | appendix | 1.00 | infobox |
| Tumor necrosis factor | Bgee | duodenum | 1.00 | infobox |
| Tumor necrosis factor | Bgee | stroma of bone marrow | 1.00 | infobox |
| Tumor necrosis factor | Bgee | embryo | 1.00 | infobox |
| Tumor necrosis factor | Bgee | wall of uterus | 1.00 | infobox |
| Tumor necrosis factor | Bgee | endometrium | 1.00 | infobox |
| Tumor necrosis factor | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| Tumor necrosis factor | Bgee | thymus | 1.00 | infobox |
| Tumor necrosis factor | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| Tumor necrosis factor | BioGPS | More reference expression data | 1.00 | infobox |
| Tumor necrosis factor | Chr. | Chromosome 6 (human) | 1.00 | infobox |
| Tumor necrosis factor | Chr. | Chromosome 17 (mouse) | 1.00 | infobox |
| Tumor necrosis factor | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Tumor necrosis factor | End | 31,578,336 bp | 1.00 | infobox |
| Tumor necrosis factor | End | 35,420,983 bp | 1.00 | infobox |
| Tumor necrosis factor | Ensembl | ENSG00000228978 ENSG00000230108 ENSG00000223952 ENSG00000204490 ENSG00000228321 ENSG00000232810 ENSG00000228849 ENSG00000206439 | 1.00 | infobox |
| Tumor necrosis factor | Entrez | 7124 | 1.00 | infobox |
| Tumor necrosis factor | External IDs | OMIM: 191160; MGI: 104798; GeneCards: TNF | 1.00 | infobox |
The concept neighborhoods around Tumor necrosis factor bring nearby vocabulary together. In this analysis, examples include Expression, Well and Induce. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Tumor necrosis factor, one of the stronger structural bridges in this analysis connects Tumor necrosis factor with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Tumor necrosis factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Gene & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Tumor necrosis factor · EN edition · Analysis: TopicsToTalkAbout