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Tumor necrosis factor: History, Gene & Function

Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are…

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Tumor necrosis factor topic overview

The analysis highlights History, Gene and Function as prominent areas in the source structure around Tumor necrosis factor.

Related topics
192
Source areas
8
Connected nodes
200
Extracted relationships
250
Concept neighborhoods
45
Bridge connections
200

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 83 topics
Clinical significance · 40 topics
Overview · 24 topics
Gene · 22 topics
Protein · 7 topics
Evolution · 6 topics
History · 5 topics
Pharmacology · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
Band
6p21.33 · 17 B1|17 18.59 cM
Bgee
granulocyte · testicle · bone marrow · monocyte · bone marrow cell
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Evolution

Gene

Protein

Function

Clinical significance

Pharmacology

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tumor necrosis factor connects Entity context

The extracted context around Tumor necrosis factor shows recurring relationship patterns in the source. For example, Tumor necrosis factor → activation of cysteine-type endopeptidase activity involved in apoptotic process, animal organ morphogenesis, apoptotic signaling pathway, cell surface, cellular extravasation, cellular response to amino acid stimulus, cellular response to lipopolysaccharide, cellular response to nicotine, cellular response to organic cyclic compound, chronic inflammatory response to antigenic stimulus, cortical actin cytoskeleton organization, cytokine activity, cytokine-mediated signaling pathway, death-inducing signaling complex assembly, defense response, defense response to bacterium, defense response to Gram-positive bacterium, embryonic digestive tract development, endothelial cell apoptotic process, epithelial cell proliferation involved in salivary gland morphogenesis Another extracted example is Tumor necrosis factor → appendix, blood, bone marrow, bone marrow cell, duodenum, embryo, endometrium, granulocyte, lymph node, mesenteric lymph nodes, monocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus, wall of uterus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tumor necrosis factor

Top relations

Gene ontology · 144
Tumor necrosis factor → activation of cysteine-type endopeptidase activity involved in apoptotic process, animal organ morphogenesis, apoptotic signaling pathway, cell surface, cellular extravasation, cellular response to amino acid stimulus, cellular response to lipopolysaccharide, cellular response to nicotine, cellular response to organic cyclic compound, chronic inflammatory response to antigenic stimulus, cortical actin cytoskeleton organization, cytokine activity, cytokine-mediated signaling pathway, death-inducing signaling complex assembly, defense response, defense response to bacterium, defense response to Gram-positive bacterium, embryonic digestive tract development, endothelial cell apoptotic process, epithelial cell proliferation involved in salivary gland morphogenesis
Bgee · 17
Tumor necrosis factor → appendix, blood, bone marrow, bone marrow cell, duodenum, embryo, endometrium, granulocyte, lymph node, mesenteric lymph nodes, monocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus, wall of uterus
RNA expression pattern · 17
Tumor necrosis factor → appendix, blood, bone marrow, bone marrow cell, duodenum, embryo, endometrium, granulocyte, lymph node, mesenteric lymph nodes, monocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus, wall of uterus
related to External links · 10
Tumor necrosis factor → Medicine Medical Subject Headings, MeSH, National Library, Overview, P01375, PDB, PDBe-KB, Tumor, Tumor Necrosis Factor-alpha, UniProt
related to history · 9
Tumor necrosis factor → Carswell, Coley's, In, Studies, These, This, TNF, TNF's, William Coley
Band · 2
Tumor necrosis factor → 17 B1|17 18.59 cM, 6p21.33
Chr. · 2
Tumor necrosis factor → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
Tumor necrosis factor → 31,578,336 bp, 35,420,983 bp
Aliases · 1
Tumor necrosis factor → TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha
Available structures · 1
Tumor necrosis factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tnf cell tnfr1 cells inflammatory tnfr2 death also tmtnf immune gene activation response complex nf-κb pathways pathway role tumor cytokines

Tumor necrosis factor relationships Subject–Predicate–Object triples

TTTA extracted 250 structured relationships around Tumor necrosis factor. Examples in this analysis include Tumor necrosis factor → Aliases → TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha and Tumor necrosis factor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tumor necrosis factorAliasesTNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha1.00infobox
Tumor necrosis factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW1.00infobox
Tumor necrosis factorBand6p21.331.00infobox
Tumor necrosis factorBand17 B1|17 18.59 cM1.00infobox
Tumor necrosis factorBgeegranulocyte1.00infobox
Tumor necrosis factorBgeetesticle1.00infobox
Tumor necrosis factorBgeebone marrow1.00infobox
Tumor necrosis factorBgeemonocyte1.00infobox
Tumor necrosis factorBgeebone marrow cell1.00infobox
Tumor necrosis factorBgeeblood1.00infobox
Tumor necrosis factorBgeelymph node1.00infobox
Tumor necrosis factorBgeespleen1.00infobox
Tumor necrosis factorBgeeappendix1.00infobox
Tumor necrosis factorBgeeduodenum1.00infobox
Tumor necrosis factorBgeestroma of bone marrow1.00infobox
Tumor necrosis factorBgeeembryo1.00infobox
Tumor necrosis factorBgeewall of uterus1.00infobox
Tumor necrosis factorBgeeendometrium1.00infobox
Tumor necrosis factorBgeesubcutaneous adipose tissue1.00infobox
Tumor necrosis factorBgeethymus1.00infobox
Tumor necrosis factorBgeemesenteric lymph nodes1.00infobox
Tumor necrosis factorBioGPSMore reference expression data1.00infobox
Tumor necrosis factorChr.Chromosome 6 (human)1.00infobox
Tumor necrosis factorChr.Chromosome 17 (mouse)1.00infobox
Tumor necrosis factorDatabasesNCBI: entry; OMA: entry1.00infobox
Tumor necrosis factorEnd31,578,336 bp1.00infobox
Tumor necrosis factorEnd35,420,983 bp1.00infobox
Tumor necrosis factorEnsemblENSG00000228978 ENSG00000230108 ENSG00000223952 ENSG00000204490 ENSG00000228321 ENSG00000232810 ENSG00000228849 ENSG000002064391.00infobox
Tumor necrosis factorEntrez71241.00infobox
Tumor necrosis factorExternal IDsOMIM: 191160; MGI: 104798; GeneCards: TNF1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tumor necrosis factor bring nearby vocabulary together. In this analysis, examples include Expression, Well and Induce. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • immune system
    • System
    • Cells
    • Response
    • Cytokines
    • Role
    • Tumor
    • Gene
    • Tnf
    • Inflammation
    • Also
    • Produced
    • Macrophages
  • cytokines
    • Immune
    • Macrophages
    • Inflammatory
    • Induce
    • Receptors
    • System
    • Tnf
    • Tnfr2
    • Cell
    • Death
    • Produced
    • Fibrosis
  • t cells
    • Immune
    • Macrophages
    • Tnf
    • Cytokines
    • Activation
    • Well
    • Cell
    • Tumor
    • Expression
    • Signalling
    • Produced
    • Tmtnf
  • b cells
    • Immune
    • Macrophages
    • Tnf
    • Cytokines
    • Activation
    • Well
    • Cell
    • Tumor
    • Expression
    • Signalling
    • Produced
    • Tmtnf
  • dendritic cells
    • Immune
    • Macrophages
    • Tnf
    • Cytokines
    • Activation
    • Well
    • Cell
    • Tumor
    • Expression
    • Signalling
    • Produced
    • Tmtnf
  • mast cells
    • Immune
    • Macrophages
    • Tnf
    • Cytokines
    • Activation
    • Well
    • Cell
    • Tumor
    • Expression
    • Signalling
    • Produced
    • Tmtnf
  • tnf alpha converting enzyme
    • Cells
    • Blockers
    • Role
    • Also
    • Liver
    • Gene
    • Immune
    • Cell
    • Receptors
    • Expression
    • Inflammatory
    • Inflammation
  • inflammatory bowel disease
    • Response
    • Pathways
    • Cell
    • Death
    • Signalling
    • Tmtnf
    • Stnf
    • Survival
    • Pathway
    • Role
    • Tnfr1
    • Well

Connections between topic areas Semantic bridges

For Tumor necrosis factor, one of the stronger structural bridges in this analysis connects Tumor necrosis factor with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tumor necrosis factorFunction · splits 117 ⟂ 84
Tumor necrosis factorClinical significance · splits 160 ⟂ 41
Tumor necrosis factorOverview · splits 176 ⟂ 25
Tumor necrosis factorGene · splits 178 ⟂ 23
Tumor necrosis factorProtein · splits 193 ⟂ 8
Tumor necrosis factorEvolution · splits 194 ⟂ 7
Tumor necrosis factorHistory · splits 195 ⟂ 6
Tumor necrosis factorPharmacology · splits 195 ⟂ 6

Map overview Semantic statistics

Tumor necrosis factor

Nodes201
Edges200
Triples250
Avg. degree1.99
Density0.00995
Components1

Source & methodology

TTTA analyzes the structure around Tumor necrosis factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Gene & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tumor necrosis factor · EN edition · Analysis: TopicsToTalkAbout

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