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Perforin-1 Perforin (PRF), encoded by the PRF1 gene, is a pore-forming toxic protein housed in the secretory granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Together, these cells are known as cytotoxic lymphocytes (CLs).
Regions, Structure and Function & Clinical Significance
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perforin cells bp membrane prf1 protein gene chr human band target cytotoxic chromosome 10 fhl cell plasma granzymes nk known
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Perforin-1 | Aliases | PRF1, FLH2, HPLH2, P1, PFN1, PFP, perforin 1 | 1.00 | infobox |
| Perforin-1 | Band | 10q22.1 | 1.00 | infobox |
| Perforin-1 | Band | 10 B4|10 32.18 cM | 1.00 | infobox |
| Perforin-1 | Bgee | granulocyte | 1.00 | infobox |
| Perforin-1 | Bgee | blood | 1.00 | infobox |
| Perforin-1 | Bgee | spleen | 1.00 | infobox |
| Perforin-1 | Bgee | decidua | 1.00 | infobox |
| Perforin-1 | Bgee | bone marrow cell | 1.00 | infobox |
| Perforin-1 | Bgee | buccal mucosa cell | 1.00 | infobox |
| Perforin-1 | Bgee | apex of heart | 1.00 | infobox |
| Perforin-1 | Bgee | lymph node | 1.00 | infobox |
| Perforin-1 | Bgee | superficial temporal artery | 1.00 | infobox |
| Perforin-1 | Bgee | upper lobe of left lung | 1.00 | infobox |
| Perforin-1 | Bgee | gastrula | 1.00 | infobox |
| Perforin-1 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| Perforin-1 | Bgee | embryo | 1.00 | infobox |
| Perforin-1 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| Perforin-1 | Bgee | thymus | 1.00 | infobox |
| Perforin-1 | Bgee | right lung | 1.00 | infobox |
| Perforin-1 | BioGPS | More reference expression data | 1.00 | infobox |
| Perforin-1 | Chr. | Chromosome 10 (human) | 1.00 | infobox |
| Perforin-1 | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| Perforin-1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Perforin-1 | End | 70,602,759 bp | 1.00 | infobox |
| Perforin-1 | End | 61,140,459 bp | 1.00 | infobox |
| Perforin-1 | Ensembl | ENSG00000180644 | 1.00 | infobox |
| Perforin-1 | Entrez | 5551 | 1.00 | infobox |
| Perforin-1 | External IDs | OMIM: 170280; MGI: 97551; GeneCards: PRF1 | 1.00 | infobox |
| Perforin-1 | Gene location (Human) | Gene location (Human)Chr.Chromosome 10 (human)Band10q22.1Start70,597,348 bpEnd70,602,759 bp | 1.00 | infobox |
| Perforin-1 | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 10 (mouse)Band10 B4|10 32.18 cMStart61,133,612 bpEnd61,140,459 bp | 1.00 | infobox |
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