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SPPL2B: Function, Structure & Overview

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.

Language: English [EN]
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SPPL2B topic overview

The analysis highlights Function, Structure and Overview as prominent areas in the source structure around SPPL2B.

Related topics
4
Source areas
3
Connected nodes
7
Extracted relationships
91
Concept neighborhoods
6
Bridge connections
7

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 2 topics
Overview · 1 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
Band
19p13.3 · 10|10 C1
Bgee
right uterine tube · anterior pituitary · left testis · right testis · right hemisphere of cerebellum
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 10 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SPPL2B connects Entity context

The extracted context around SPPL2B shows recurring relationship patterns in the source. For example, SPPL2B → actin cytoskeleton, aspartic endopeptidase activity, intramembrane cleaving, aspartic-type endopeptidase activity, centrosome, endosome, endosome membrane, Golgi apparatus, Golgi membrane, Golgi-associated vesicle membrane, hydrolase activity, integral component of cytoplasmic side of endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane, integral component of membrane, lysosomal membrane, lysosome, membrane, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, membrane protein proteolysis, nucleoplasm Another extracted example is SPPL2B → anterior pituitary, body of pancreas, external carotid artery, fetal liver hematopoietic progenitor cell, left lobe of thyroid gland, left testis, motor neuron, mucosa of transverse colon, neural layer of retina, otic placode, otic vesicle, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, Rostral migratory stream, saccule, spermatid, spermatocyte, transverse colon. Use these groups to spot repeated connection types before inspecting the individual relationships.

SPPL2B

Top relations

Gene ontology · 27
SPPL2B → actin cytoskeleton, aspartic endopeptidase activity, intramembrane cleaving, aspartic-type endopeptidase activity, centrosome, endosome, endosome membrane, Golgi apparatus, Golgi membrane, Golgi-associated vesicle membrane, hydrolase activity, integral component of cytoplasmic side of endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane, integral component of membrane, lysosomal membrane, lysosome, membrane, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, membrane protein proteolysis, nucleoplasm
Bgee · 20
SPPL2B → anterior pituitary, body of pancreas, external carotid artery, fetal liver hematopoietic progenitor cell, left lobe of thyroid gland, left testis, motor neuron, mucosa of transverse colon, neural layer of retina, otic placode, otic vesicle, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, Rostral migratory stream, saccule, spermatid, spermatocyte, transverse colon
RNA expression pattern · 20
SPPL2B → anterior pituitary, body of pancreas, external carotid artery, fetal liver hematopoietic progenitor cell, left lobe of thyroid gland, left testis, motor neuron, mucosa of transverse colon, neural layer of retina, otic placode, otic vesicle, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, Rostral migratory stream, saccule, spermatid, spermatocyte, transverse colon
related to Function · 4
SPPL2B → APP, Aβ, This, TNFα
Band · 2
SPPL2B → 10|10 C1, 19p13.3
Chr. · 2
SPPL2B → Chromosome 10 (mouse), Chromosome 19 (human)
End · 2
SPPL2B → 2,355,095 bp, 80,704,542 bp
Aliases · 1
SPPL2B → SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
BioGPS · 1
SPPL2B → More reference expression data
Databases · 1
SPPL2B → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp chr band chromosome 19 signal peptide location mouse 2b function peptidase-like also peptidase external 355 095 end

SPPL2B relationships Subject–Predicate–Object triples

TTTA extracted 91 structured relationships around SPPL2B. Examples in this analysis include SPPL2B → Aliases → SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B and SPPL2B → Band → 19p13.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SPPL2BAliasesSPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B1.00infobox
SPPL2BBand19p13.31.00infobox
SPPL2BBand10|10 C11.00infobox
SPPL2BBgeeright uterine tube1.00infobox
SPPL2BBgeeanterior pituitary1.00infobox
SPPL2BBgeeleft testis1.00infobox
SPPL2BBgeeright testis1.00infobox
SPPL2BBgeeright hemisphere of cerebellum1.00infobox
SPPL2BBgeetransverse colon1.00infobox
SPPL2BBgeeright lobe of thyroid gland1.00infobox
SPPL2BBgeebody of pancreas1.00infobox
SPPL2BBgeeleft lobe of thyroid gland1.00infobox
SPPL2BBgeemucosa of transverse colon1.00infobox
SPPL2BBgeespermatocyte1.00infobox
SPPL2BBgeefetal liver hematopoietic progenitor cell1.00infobox
SPPL2BBgeespermatid1.00infobox
SPPL2BBgeemotor neuron1.00infobox
SPPL2BBgeesaccule1.00infobox
SPPL2BBgeeneural layer of retina1.00infobox
SPPL2BBgeeotic vesicle1.00infobox
SPPL2BBgeeotic placode1.00infobox
SPPL2BBgeeexternal carotid artery1.00infobox
SPPL2BBgeeRostral migratory stream1.00infobox
SPPL2BBioGPSMore reference expression data1.00infobox
SPPL2BChr.Chromosome 19 (human)1.00infobox
SPPL2BChr.Chromosome 10 (mouse)1.00infobox
SPPL2BDatabasesNCBI: entry; OMA: entry1.00infobox
SPPL2BEnd2,355,095 bp1.00infobox
SPPL2BEnd80,704,542 bp1.00infobox
SPPL2BEnsemblENSG000000052061.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SPPL2B bring nearby vocabulary together. In this analysis, examples include Peptidase, Location and Structure. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Human
    • Location
    • Peptide
    • Signal
    • Chromosome
    • Sppl2b
    • Bp
    • Chr
    • End
    • External
    • Function
    • Mouse
  • signal peptide peptidase
    • Signal
    • 2b
    • Location
    • Peptidase-like
    • Gene
    • Reading
    • References
    • Sppl2b
    • Structure
    • Subcellular
    • Cleaving
    • Distribution
  • function
    • External
    • Peptidase
    • Location
    • Chromosome
    • Reading
    • References
    • Sppl2b
    • Structure
    • Subcellular
    • Bp
    • Chr
    • Gene
  • SPPL2B
    • Peptidase
    • Location
    • Structure
    • Subcellular
    • Cleaving
    • End
    • Membrane
    • Mouse
    • Plasma
    • Protein
    • Band
  • sppl2b
    • Peptidase
    • Location
    • Structure
    • Subcellular
    • Cleaving
    • End
    • Membrane
    • Mouse
    • Plasma
    • Protein
    • Band
  • structure
    • Reading
    • References
    • Subcellular
    • Peptidase
    • Location
    • Sppl2b

Connections between topic areas Semantic bridges

For SPPL2B, one of the stronger structural bridges in this analysis connects SPPL2B with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SPPL2BFunction · splits 5 ⟂ 3

Map overview Semantic statistics

SPPL2B

Nodes8
Edges7
Triples91
Avg. degree1.75
Density0.25
Components1

Source & methodology

TTTA analyzes the structure around SPPL2B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SPPL2B · EN edition · Analysis: TopicsToTalkAbout

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