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A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation.
Function, Activation & Interactions
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| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ADAM17 | 3.4.24.86 | ↗ | 1.00 | infobox |
| ADAM17 | Aliases | ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17 | 1.00 | infobox |
| ADAM17 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T,… | 1.00 | infobox |
| ADAM17 | Band | 2p25.1 | 1.00 | infobox |
| ADAM17 | Band | 12 A1.3|12 8.3 cM | 1.00 | infobox |
| ADAM17 | Bgee | oocyte | 1.00 | infobox |
| ADAM17 | Bgee | Achilles tendon | 1.00 | infobox |
| ADAM17 | Bgee | pericardium | 1.00 | infobox |
| ADAM17 | Bgee | monocyte | 1.00 | infobox |
| ADAM17 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| ADAM17 | Bgee | sural nerve | 1.00 | infobox |
| ADAM17 | Bgee | lower lobe of lung | 1.00 | infobox |
| ADAM17 | Bgee | right lung | 1.00 | infobox |
| ADAM17 | Bgee | gallbladder | 1.00 | infobox |
| ADAM17 | Bgee | upper lobe of lung | 1.00 | infobox |
| ADAM17 | Bgee | otic vesicle | 1.00 | infobox |
| ADAM17 | Bgee | saccule | 1.00 | infobox |
| ADAM17 | Bgee | otic placode | 1.00 | infobox |
| ADAM17 | Bgee | primary oocyte | 1.00 | infobox |
| ADAM17 | Bgee | secondary oocyte | 1.00 | infobox |
| ADAM17 | Bgee | cumulus cell | 1.00 | infobox |
| ADAM17 | Bgee | genital tubercle | 1.00 | infobox |
| ADAM17 | Bgee | tail of embryo | 1.00 | infobox |
| ADAM17 | Bgee | stroma of bone marrow | 1.00 | infobox |
| ADAM17 | Bgee | left lung lobe | 1.00 | infobox |
| ADAM17 | BioGPS | More reference expression data | 1.00 | infobox |
| ADAM17 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| ADAM17 | Chr. | Chromosome 12 (mouse) | 1.00 | infobox |
| ADAM17 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ADAM17 | End | 9,556,732 bp | 1.00 | infobox |
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