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A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation.
The analysis highlights Function, Activation and Interactions as prominent areas in the source structure around ADAM17.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around ADAM17 shows recurring relationship patterns in the source. For example, ADAM17 → actin cytoskeleton, apical plasma membrane, B cell differentiation, cell adhesion, cell adhesion mediated by integrin, cell motility, cell surface, cell-cell junction, cellular response to high density lipoprotein particle stimulus, cytoplasm, cytosol, defense response to Gram-positive bacterium, endopeptidase activity, epidermal growth factor receptor signaling pathway, focal adhesion, germinal center formation, hydrolase activity, integral component of membrane, integral component of plasma membrane, integrin binding Another extracted example is ADAM17 → Achilles tendon, cumulus cell, gallbladder, genital tubercle, left lung lobe, lower lobe of lung, monocyte, oocyte, otic placode, otic vesicle, pericardium, primary oocyte, right lung, saccule, secondary oocyte, stroma of bone marrow, sural nerve, tail of embryo, tendon of biceps brachii, upper lobe of lung. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cell also human activity bp gene domain tnf-α chr band soluble may ectodomain signaling location shedding chromosome membrane surface intracellular
TTTA extracted 169 structured relationships around ADAM17. Examples in this analysis include ADAM17 → 3.4.24.86 → ↗ and ADAM17 → Aliases → ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ADAM17 | 3.4.24.86 | ↗ | 1.00 | infobox |
| ADAM17 | Aliases | ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17 | 1.00 | infobox |
| ADAM17 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T,… | 1.00 | infobox |
| ADAM17 | Band | 2p25.1 | 1.00 | infobox |
| ADAM17 | Band | 12 A1.3|12 8.3 cM | 1.00 | infobox |
| ADAM17 | Bgee | oocyte | 1.00 | infobox |
| ADAM17 | Bgee | Achilles tendon | 1.00 | infobox |
| ADAM17 | Bgee | pericardium | 1.00 | infobox |
| ADAM17 | Bgee | monocyte | 1.00 | infobox |
| ADAM17 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| ADAM17 | Bgee | sural nerve | 1.00 | infobox |
| ADAM17 | Bgee | lower lobe of lung | 1.00 | infobox |
| ADAM17 | Bgee | right lung | 1.00 | infobox |
| ADAM17 | Bgee | gallbladder | 1.00 | infobox |
| ADAM17 | Bgee | upper lobe of lung | 1.00 | infobox |
| ADAM17 | Bgee | otic vesicle | 1.00 | infobox |
| ADAM17 | Bgee | saccule | 1.00 | infobox |
| ADAM17 | Bgee | otic placode | 1.00 | infobox |
| ADAM17 | Bgee | primary oocyte | 1.00 | infobox |
| ADAM17 | Bgee | secondary oocyte | 1.00 | infobox |
| ADAM17 | Bgee | cumulus cell | 1.00 | infobox |
| ADAM17 | Bgee | genital tubercle | 1.00 | infobox |
| ADAM17 | Bgee | tail of embryo | 1.00 | infobox |
| ADAM17 | Bgee | stroma of bone marrow | 1.00 | infobox |
| ADAM17 | Bgee | left lung lobe | 1.00 | infobox |
| ADAM17 | BioGPS | More reference expression data | 1.00 | infobox |
| ADAM17 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| ADAM17 | Chr. | Chromosome 12 (mouse) | 1.00 | infobox |
| ADAM17 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ADAM17 | End | 9,556,732 bp | 1.00 | infobox |
The concept neighborhoods around ADAM17 bring nearby vocabulary together. In this analysis, examples include Also, May and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ADAM17, one of the stronger structural bridges in this analysis connects ADAM17 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ADAM17 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Activation & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ADAM17 · EN edition · Analysis: TopicsToTalkAbout