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NFKB2: Measurement, Interactions & Clinical significance

Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene.

Language: English [EN]
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NFKB2 topic overview

The analysis highlights Measurement, Interactions and Clinical significance as prominent areas in the source structure around NFKB2.

Related topics
14
Source areas
3
Connected nodes
17
Extracted relationships
123
Concept neighborhoods
4
Bridge connections
17

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 10 topics
Clinical significance · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52, p100, p49/p100, nuclear factor kappa B subunit 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A3Q, 2D96, 3DO7, 4OT9
Band
10q24.32 · 19 C3|19 38.8 cM
Bgee
granulocyte · muscle layer of sigmoid colon · spleen · epithelium of colon · monocyte
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NFKB2 connects Entity context

The extracted context around NFKB2 shows recurring relationship patterns in the source. For example, NFKB2 → ageing, Bcl3/NF-kappaB2 complex, chromatin binding, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, extracellular matrix organization, follicular dendritic cell differentiation, germinal center formation, I-kappaB kinase/NF-kappaB signaling, inflammatory response, innate immune response, negative regulation of transcription by RNA polymerase II, NIK/NF-kappaB signaling, nucleoplasm, nucleus, positive regulation of NF-kappaB transcription factor activity Another extracted example is NFKB2 → aortic valve, ascending aorta, cumulus cell, epithelium of colon, gallbladder, granulocyte, left uterine tube, lip, lymph node, mesenteric lymph nodes, monocyte, motor neuron, muscle layer of sigmoid colon, renal vein, spleen, sural nerve, thymus, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

NFKB2

Top relations

Gene ontology · 33
NFKB2 → ageing, Bcl3/NF-kappaB2 complex, chromatin binding, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, extracellular matrix organization, follicular dendritic cell differentiation, germinal center formation, I-kappaB kinase/NF-kappaB signaling, inflammatory response, innate immune response, negative regulation of transcription by RNA polymerase II, NIK/NF-kappaB signaling, nucleoplasm, nucleus, positive regulation of NF-kappaB transcription factor activity
Bgee · 18
NFKB2 → aortic valve, ascending aorta, cumulus cell, epithelium of colon, gallbladder, granulocyte, left uterine tube, lip, lymph node, mesenteric lymph nodes, monocyte, motor neuron, muscle layer of sigmoid colon, renal vein, spleen, sural nerve, thymus, upper lobe of left lung
RNA expression pattern · 18
NFKB2 → aortic valve, ascending aorta, cumulus cell, epithelium of colon, gallbladder, granulocyte, left uterine tube, lip, lymph node, mesenteric lymph nodes, monocyte, motor neuron, muscle layer of sigmoid colon, renal vein, spleen, sural nerve, thymus, upper lobe of left lung
related to External links · 12
NFKB2 → Human Nuclear, Medicine Medical Subject Headings, MeSH, Mouse Nuclear, National Library, NF-kappa-B, Overview, PDB, PDBe-KB, Q00653, Q9WTK5, UniProt
related to Interactions · 8
NFKB2 → BCL3, BTRC, MAP3K8, NFKB1, NFKBIE, REL, RELA, RELB
related to Clinical significance · 5
NFKB2 → C-terminus, CVID, DAVID, The, Though
Band · 2
NFKB2 → 10q24.32, 19 C3|19 38.8 cM
Chr. · 2
NFKB2 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
NFKB2 → 102,402,524 bp, 46,300,824 bp
Aliases · 1
NFKB2 → NFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52, p100, p49/p100, nuclear factor kappa B subunit 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene chr band factor nf-kappa-b chromosome 10 protein nuclear p100 subunit mouse location pdb uniprot cvid mutation endocrine

NFKB2 relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around NFKB2. Examples in this analysis include NFKB2 → Aliases → NFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52, p100, p49/p100, nuclear factor kappa B subunit 2 and NFKB2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A3Q, 2D96, 3DO7, 4OT9. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NFKB2AliasesNFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52, p100, p49/p100, nuclear factor kappa B subunit 21.00infobox
NFKB2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A3Q, 2D96, 3DO7, 4OT91.00infobox
NFKB2Band10q24.321.00infobox
NFKB2Band19 C3|19 38.8 cM1.00infobox
NFKB2Bgeegranulocyte1.00infobox
NFKB2Bgeemuscle layer of sigmoid colon1.00infobox
NFKB2Bgeespleen1.00infobox
NFKB2Bgeeepithelium of colon1.00infobox
NFKB2Bgeemonocyte1.00infobox
NFKB2Bgeeleft uterine tube1.00infobox
NFKB2Bgeelymph node1.00infobox
NFKB2Bgeeupper lobe of left lung1.00infobox
NFKB2Bgeegallbladder1.00infobox
NFKB2Bgeesural nerve1.00infobox
NFKB2Bgeemesenteric lymph nodes1.00infobox
NFKB2Bgeeaortic valve1.00infobox
NFKB2Bgeecumulus cell1.00infobox
NFKB2Bgeeascending aorta1.00infobox
NFKB2Bgeemotor neuron1.00infobox
NFKB2Bgeethymus1.00infobox
NFKB2Bgeelip1.00infobox
NFKB2Bgeerenal vein1.00infobox
NFKB2BioGPSMore reference expression data1.00infobox
NFKB2Chr.Chromosome 10 (human)1.00infobox
NFKB2Chr.Chromosome 19 (mouse)1.00infobox
NFKB2DatabasesNCBI: entry; OMA: entry1.00infobox
NFKB2End102,402,524 bp1.00infobox
NFKB2End46,300,824 bp1.00infobox
NFKB2EnsemblENSG000000771501.00infobox
NFKB2Entrez47911.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NFKB2 bring nearby vocabulary together. In this analysis, examples include Mutation, Protein and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NFKB2
    • Mutation
    • Protein
    • Gene
    • Disease
    • Cvid
    • Endocrine
    • Human
    • Function
    • Search
    • Lead
    • Location
    • Nf-κb
  • nfkb2
    • Mutation
    • Protein
    • Gene
    • Disease
    • Cvid
    • Endocrine
    • Human
    • Function
    • Search
    • Lead
    • Location
    • Nf-κb
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • C3
    • End
    • Function
    • Search
    • Human
    • Disease
    • Mouse
    • Nfkb2
  • protein
    • Nf-κb
    • Human
    • C3
    • Cell
    • End
    • Function
    • Q00653
    • Q9wtk5
    • Search
    • Disease
    • Lead
    • Location

Connections between topic areas Semantic bridges

For NFKB2, one of the stronger structural bridges in this analysis connects NFKB2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NFKB2Interactions · splits 7 ⟂ 11
NFKB2Overview · splits 15 ⟂ 3
NFKB2Clinical significance · splits 15 ⟂ 3

Map overview Semantic statistics

NFKB2

Nodes18
Edges17
Triples123
Avg. degree1.89
Density0.111111
Components1

Source & methodology

TTTA analyzes the structure around NFKB2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NFKB2 · EN edition · Analysis: TopicsToTalkAbout

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