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Pyroptosis

Pyroptosis is a highly inflammatory form of lytic programmed cell death that occurs most frequently upon infection with intracellular pathogens and forms part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the…

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Map overview Semantic statistics

Pyroptosis

Nodes86
Edges85
Triples138
Avg. degree1.98
Density0.023256
Components1

How this topic connects Entity context

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Pyroptosis

Top relations

related to The canonical inflammasome pathway · 38
Pyroptosis → AIM2, Also, Alternatively, ASC, Both, Canonical, CARD, CARD-CARD, DAMPs, For, Generally, IFN, III, IL-12, IL-18, IL-1β, IL-6, In, LRR, MAPK-signaling
related to Discovery · 23
Pyroptosis → After, Also, Arturo Zychlinsky, Brad, Caspase-1, Cookson, Dr, EM, GSDMD, However, In, Inflammasome, It, LPS, Molly Brennan, NINJ1, Shigella, The, The Greek, TLR4
related to Caspase-3-dependent cell death pathway · 14
Pyroptosis → Additionally, An, C-terminal, Caspase-3, GSDMA, GSDMB, GSDMC, GSDMD, GSDME, It, N-terminal, The, This, When
related to HIV and AIDS · 13
Pyroptosis → AIDS, Although, Caspase-1, CD4, CD4 T-cell, HIV, HIV-1, HIV-infected, In, It, Of, Recent, These
related to Cancer · 9
Pyroptosis → A2/CDK2, Also, DAMPs, GSDMD, GSDME, However, In, Principally, Understanding
related to Infection · 9
Pyroptosis → IFNγ, IL-18, IL-1β, In, Salmonella, Shigella, TH1, The, When
related to Mechanism · 9
Pyroptosis → Classic, DAMPs, NLRs, NOD-like, PAMPs, PRRs, Recognition, The, TLRs
related to The noncanonical inflammasome pathway · 8
Pyroptosis → Binding, GSDMD, GSDMD-N, In, LPS, NLRP3, The, These
related to Morphological characteristics · 4
Pyroptosis → Both, Caspase-3, Caspase-8, In
is a · 1
Pyroptosis → highly inflammatory form of lytic programmed cell death that occurs most frequently upon infection with intracellular pathogens and forms part of the antimicrobial response

Important terminology Word statistics

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Important terminology

cell caspase-1 cells inflammasome form also inflammatory death infection activation membrane cytokines gsdmd formation apoptosis inflammation caspases inflammasomes cancer pathway

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pyroptosisis ahighly inflammatory form of lytic programmed cell death that occurs most frequently upon infection with intracellular pathogens and forms part of the antimicrobial response0.90text
HMGB-1instance ofmolecules0.80text
ATPinstance ofmolecules0.80text
DNAinstance ofmolecules0.80text
out of the cellinstance ofmolecules0.80text
TLRsinstance ofnon-inflammasome-forming PRRs0.80text
NOD1instance ofnon-inflammasome-forming PRRs0.80text
NOD2 also play important roles in pyroptosisinstance ofnon-inflammasome-forming PRRs0.80text
IFN α/βinstance ofThese receptors upregulate expression of inflammatory cytokines0.80text
tumour necrosis factorinstance ofThese receptors upregulate expression of inflammatory cytokines0.80text
Pyroptosisrelated to CancerPrincipally0.60section
Pyroptosisrelated to CancerDAMPs0.60section

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