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FADD

FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.

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Aliases
FADD, GIG3, MORT1, Fas associated via death domain, IMD90
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ
Band
11q13.3
Bgee
granulocyte · tendon of biceps brachii · stromal cell of endometrium · mucosa of transverse colon · blood
BioGPS
More reference expression data
Chr.
Chromosome 11 (human)

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Functions

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Roles in inflammatory diseases

Roles in cancer

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FADD

Nodes98
Edges97
Triples257
Avg. degree1.98
Density0.020408
Components1

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FADD

Top relations

Gene ontology · 71
FADD → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, apoptotic signaling pathway, behavioral response to cocaine, caspase binding, CD95 death-inducing signaling complex, cell body, cell surface receptor signaling pathway, cellular response to mechanical stimulus, cytoplasm, cytosol, death effector domain binding, death receptor binding, death-inducing signaling complex, death-inducing signaling complex assembly, defense response to virus, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors
related to Extrinsic apoptosis · 17
FADD → Binding, DD, DEDs, DISC, DNase, DR4, DR5, FADD's DED, Fas, ICAD, Many, Procaspase, The, These, This, TRAIL, Upon
related to Inflammation · 17
FADD → Activation, Conversely, DD, DD-DD, FADD-deficient, Fas, IL-1, IL-1R1, IRAK, It, Kinase, MyD88, NFκB, Normally, This, TL4, TNF-R1
related to Interactions · 14
FADD → ABCA1, ATG5, C-FLIP, Casein Kinase, DEDD, Fas, MBD4MyD88, MKRN1, NACA, PEA15, RIPK1, RIPK3, TRADD, TRAIL
related to c-FLIP · 13
FADD → C-FLIP, C-FLIPS, Cellular FLICE, DED, DEDs, DISC, FLIP, FLIPL, However, It, There, Therefore, Without
related to Therapeutic target · 11
FADD → For, G2/M, However, It, JNK, NF-κB, Phosphorylated FADD, Ser194, Taxol, Therefore, This
Bgee · 10
FADD → blood, epithelium of esophagus, granulocyte, left adrenal gland, mucosa of transverse colon, parotid gland, right adrenal cortex, right adrenal gland, stromal cell of endometrium, tendon of biceps brachii
RNA expression pattern · 10
FADD → blood, epithelium of esophagus, granulocyte, left adrenal gland, mucosa of transverse colon, parotid gland, right adrenal cortex, right adrenal gland, stromal cell of endometrium, tendon of biceps brachii
related to Cell cycle regulation · 8
FADD → As, Casein Kinase, CKIα, G1, G2, G2/M, Serine, This
related to Structure · 8
FADD → DD, DED, Each, Fas, It, The, The DD, The DED

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Important terminology

cell death also protein apoptosis receptor domain cells procaspase role cycle fas complex development nfκb interaction pathway receptors activation nucleus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FADDAliasesFADD, GIG3, MORT1, Fas associated via death domain, IMD901.00infobox
FADDAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ1.00infobox
FADDBand11q13.31.00infobox
FADDBgeegranulocyte1.00infobox
FADDBgeetendon of biceps brachii1.00infobox
FADDBgeestromal cell of endometrium1.00infobox
FADDBgeemucosa of transverse colon1.00infobox
FADDBgeeblood1.00infobox
FADDBgeeparotid gland1.00infobox
FADDBgeeright adrenal gland1.00infobox
FADDBgeeright adrenal cortex1.00infobox
FADDBgeeleft adrenal gland1.00infobox
FADDBgeeepithelium of esophagus1.00infobox
FADDBioGPSMore reference expression data1.00infobox
FADDChr.Chromosome 11 (human)1.00infobox
FADDDatabasesNCBI: entry; OMA: entry1.00infobox
FADDEnd70,207,390 bp1.00infobox
FADDEnsemblENSG000001680401.00infobox
FADDEntrez87721.00infobox
FADDExternal IDsOMIM: 602457; MGI: 109324; GeneCards: FADD1.00infobox
FADDGene location (Human)Gene location (Human)Chr.Chromosome 11 (human)Band11q13.3Start70,203,296 bpEnd70,207,390 bp1.00infobox
FADDGene ontologyidentical protein binding1.00infobox
FADDGene ontologytumor necrosis factor receptor superfamily binding1.00infobox
FADDGene ontologydeath effector domain binding1.00infobox
FADDGene ontologycaspase binding1.00infobox
FADDGene ontologyprotein binding1.00infobox
FADDGene ontologyprotease binding1.00infobox
FADDGene ontologydeath receptor binding1.00infobox
FADDGene ontologytumor necrosis factor receptor binding1.00infobox
FADDGene ontologyreceptor serine/threonine kinase binding1.00infobox

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