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RIPK1

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in apoptosis, necroptosis, and PANoptosis. Some of the cell survival pathways RIPK1 participates in include NF-κB, Akt, and JNK.

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2.7.11.1
Aliases
RIPK1, RIP, RIP1, RIP-1, receptor interacting serine/threonine kinase 1, IMD57, AIEFL
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ITH, 4ITI, 4ITJ, 4NEU, 5HX6
Band
6p25.2 · 13 A3.3|13 14.01 cM
Bgee
granulocyte · sural nerve · right lobe of liver · stromal cell of endometrium · gastric mucosa
BioGPS
More reference expression data

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Neurodegenerative diseases

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RIPK1

Nodes75
Edges74
Triples246
Avg. degree1.97
Density0.026667
Components1

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RIPK1

Top relations

Gene ontology · 87
RIPK1 → activation of cysteine-type endopeptidase activity involved in apoptotic process, amyloid fibril formation, apoptotic process, apoptotic signaling pathway, ATP binding, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to tumor necrosis factor, cytoplasm, cytosol, death domain binding, death receptor binding, death-inducing signaling complex, death-inducing signaling complex assembly, endosome membrane, extrinsic apoptotic signaling pathway, I-kappaB kinase/NF-kappaB signaling, identical protein binding, JUN kinase kinase kinase activity, kinase activity
related to Structure · 28
RIPK1 → C-Terminus, DD, DR4, DR5, FADD, Fas, ID, It, KD, N-Terminus, Necrostatin-1, NEMO, NF-kB, OPTN, Overexpression, RHIM, RIP, RIPK3, The, The KD
Bgee · 19
RIPK1 → Achilles tendon, apex of heart, conjunctival fornix, endothelial cell of lymphatic vessel, epithelium of stomach, fetal liver hematopoietic progenitor cell, gastric mucosa, granulocyte, jejunum, left lobe of liver, Paneth cell, renal corpuscle, right coronary artery, right lobe of liver, skin of abdomen, skin of leg, stroma of bone marrow, stromal cell of endometrium, sural nerve
RNA expression pattern · 19
RIPK1 → Achilles tendon, apex of heart, conjunctival fornix, endothelial cell of lymphatic vessel, epithelium of stomach, fetal liver hematopoietic progenitor cell, gastric mucosa, granulocyte, jejunum, left lobe of liver, Paneth cell, renal corpuscle, right coronary artery, right lobe of liver, skin of abdomen, skin of leg, stroma of bone marrow, stromal cell of endometrium, sural nerve
related to Interactions · 15
RIPK1 → BIRC2, BIRC3, CA11, CASP8, CFLAR, CRADD, RIPK2, RIPK3, RNF11, RNF216, SQSTM1, TNFRSF1A, TRADD, TRAF2, UBC
related to Amyotrophic Lateral Sclerosis · 11
RIPK1 → ALS, Amyotrophic Lateral Sclerosis, Central Nervous System, CNS, Consequently, MLKL, OPTN, Receptor Interacting Protein, RIPK3, The, When
related to Function · 10
RIPK1 → Also, Although, C-terminal, IAP1/2, Kinase, MLKL, RIPK1-dependent, RIPK3, The, TNFR
related to Alzheimer's disease · 4
RIPK1 → AD, Alzheimer's, Patients, This
related to Autoinflamatory disease · 4
RIPK1 → An, Cleavage-resistant RIPK1-induced, CRIA, Symptoms
related to Role in cell survival · 4
RIPK1 → DNA, It, NF-kB, RIPK1-mediated

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Important terminology

cell complex death kinase activation survival protein nf-kb ripk3 domain necroptosis receptor gene apoptosis also bp activity chromosome traf2 signalling

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RIPK12.7.11.11.00infobox
RIPK1AliasesRIPK1, RIP, RIP1, RIP-1, receptor interacting serine/threonine kinase 1, IMD57, AIEFL1.00infobox
RIPK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ITH, 4ITI, 4ITJ, 4NEU, 5HX61.00infobox
RIPK1Band6p25.21.00infobox
RIPK1Band13 A3.3|13 14.01 cM1.00infobox
RIPK1Bgeegranulocyte1.00infobox
RIPK1Bgeesural nerve1.00infobox
RIPK1Bgeeright lobe of liver1.00infobox
RIPK1Bgeestromal cell of endometrium1.00infobox
RIPK1Bgeegastric mucosa1.00infobox
RIPK1BgeeAchilles tendon1.00infobox
RIPK1Bgeeright coronary artery1.00infobox
RIPK1Bgeeskin of abdomen1.00infobox
RIPK1Bgeeskin of leg1.00infobox
RIPK1Bgeeapex of heart1.00infobox
RIPK1Bgeerenal corpuscle1.00infobox
RIPK1BgeePaneth cell1.00infobox
RIPK1Bgeeendothelial cell of lymphatic vessel1.00infobox
RIPK1Bgeestroma of bone marrow1.00infobox
RIPK1Bgeeleft lobe of liver1.00infobox
RIPK1Bgeeepithelium of stomach1.00infobox
RIPK1Bgeejejunum1.00infobox
RIPK1Bgeeconjunctival fornix1.00infobox
RIPK1Bgeefetal liver hematopoietic progenitor cell1.00infobox
RIPK1BioGPSMore reference expression data1.00infobox
RIPK1Chr.Chromosome 6 (human)1.00infobox
RIPK1Chr.Chromosome 13 (mouse)1.00infobox
RIPK1DatabasesNCBI: entry; OMA: entry1.00infobox
RIPK1End3,115,187 bp1.00infobox
RIPK1End34,221,130 bp1.00infobox

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