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IKBKG: Music, Regions & Measurement

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. The human gene for IKBKG is located on the chromosome band Xq28. Multiple transcript variants encoding different…

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IKBKG topic overview

The analysis highlights Music, Regions and Measurement as prominent areas in the source structure around IKBKG.

Related topics
49
Source areas
4
Connected nodes
53
Extracted relationships
135
Concept neighborhoods
14
Bridge connections
53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

As a drug target · 27 topics
Interactions · 12 topics
Clinical significance · 5 topics
Overview · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma,…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY
Band
Xq28 · X|X A7.3
Bgee
granulocyte · blood · spleen · right lobe of liver · upper lobe of left lung
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

As a drug target

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How IKBKG connects Entity context

The extracted context around IKBKG shows recurring relationship patterns in the source. For example, IKBKG → anoikis, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, apoptotic process, cellular response to DNA damage stimulus, cytoplasm, cytosol, establishment of vesicle localization, Fc-epsilon receptor signaling pathway, I-kappaB kinase/NF-kappaB signaling, identical protein binding, IkappaB kinase complex, immune response, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, intracellular anatomical structure, JNK cascade, K63-linked polyubiquitin modification-dependent protein binding, linear polyubiquitin binding, metal ion binding Another extracted example is IKBKG → blood, cardiac muscle tissue of left ventricle, dentate gyrus of hippocampal formation granule cell, endothelial cell of lymphatic vessel, granulocyte, left adrenal cortex, left adrenal gland, left lobe of liver, lumbar subsegment of spinal cord, monocyte, neural layer of retina, right adrenal cortex, right lobe of liver, right lung, spleen, stroma of bone marrow, transitional epithelium of urinary bladder, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

IKBKG

Top relations

Gene ontology · 49
IKBKG → anoikis, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, apoptotic process, cellular response to DNA damage stimulus, cytoplasm, cytosol, establishment of vesicle localization, Fc-epsilon receptor signaling pathway, I-kappaB kinase/NF-kappaB signaling, identical protein binding, IkappaB kinase complex, immune response, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, intracellular anatomical structure, JNK cascade, K63-linked polyubiquitin modification-dependent protein binding, linear polyubiquitin binding, metal ion binding
Bgee · 18
IKBKG → blood, cardiac muscle tissue of left ventricle, dentate gyrus of hippocampal formation granule cell, endothelial cell of lymphatic vessel, granulocyte, left adrenal cortex, left adrenal gland, left lobe of liver, lumbar subsegment of spinal cord, monocyte, neural layer of retina, right adrenal cortex, right lobe of liver, right lung, spleen, stroma of bone marrow, transitional epithelium of urinary bladder, upper lobe of left lung
RNA expression pattern · 18
IKBKG → blood, cardiac muscle tissue of left ventricle, dentate gyrus of hippocampal formation granule cell, endothelial cell of lymphatic vessel, granulocyte, left adrenal cortex, left adrenal gland, left lobe of liver, lumbar subsegment of spinal cord, monocyte, neural layer of retina, right adrenal cortex, right lobe of liver, right lung, spleen, stroma of bone marrow, transitional epithelium of urinary bladder, upper lobe of left lung
related to Interactions · 9
IKBKG → BCL10, CDC37, CHUK, IRAK1, NCOA3, PPM1B, TANK, TNFAIP3, TRAF3IP2
related to External links · 8
IKBKG → Anophthalmia, GeneReviews/NCBI/NIH/UW, GeneReviews/NIH/NCBI/UW, Incontinentia PigmentiOMIM IKBKG, Medicine Medical Subject Headings, MeSH, Microphthalmia Overview, National Library
related to Clinical significance · 7
IKBKG → Incontinentia Pigmenti, IP, Mutations, NF-κB, Since IKBKG, TNF-alpha, X-linked
Band · 2
IKBKG → Xq28, X|X A7.3
Chr. · 2
IKBKG → X chromosome (human), X chromosome (mouse)
End · 2
IKBKG → 154,565,046 bp, 73,497,460 bp
Aliases · 1
IKBKG → IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nemo nf-κb gene peptide nbd human complex subunit band kinase bp chromosome chr binding ikk ikk-γ mouse activity activation inflammation

IKBKG relationships Subject–Predicate–Object triples

TTTA extracted 135 structured relationships around IKBKG. Examples in this analysis include IKBKG → Aliases → IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma,… and IKBKG → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IKBKGAliasesIKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma,…1.00infobox
IKBKGAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY1.00infobox
IKBKGBandXq281.00infobox
IKBKGBandX|X A7.31.00infobox
IKBKGBgeegranulocyte1.00infobox
IKBKGBgeeblood1.00infobox
IKBKGBgeespleen1.00infobox
IKBKGBgeeright lobe of liver1.00infobox
IKBKGBgeeupper lobe of left lung1.00infobox
IKBKGBgeeright adrenal cortex1.00infobox
IKBKGBgeeleft adrenal gland1.00infobox
IKBKGBgeeleft adrenal cortex1.00infobox
IKBKGBgeemonocyte1.00infobox
IKBKGBgeeright lung1.00infobox
IKBKGBgeeleft lobe of liver1.00infobox
IKBKGBgeeneural layer of retina1.00infobox
IKBKGBgeeendothelial cell of lymphatic vessel1.00infobox
IKBKGBgeedentate gyrus of hippocampal formation granule cell1.00infobox
IKBKGBgeelumbar subsegment of spinal cord1.00infobox
IKBKGBgeetransitional epithelium of urinary bladder1.00infobox
IKBKGBgeestroma of bone marrow1.00infobox
IKBKGBgeecardiac muscle tissue of left ventricle1.00infobox
IKBKGBioGPSMore reference expression data1.00infobox
IKBKGChr.X chromosome (human)1.00infobox
IKBKGChr.X chromosome (mouse)1.00infobox
IKBKGDatabasesNCBI: entry; OMA: entry1.00infobox
IKBKGEnd154,565,046 bp1.00infobox
IKBKGEnd73,497,460 bp1.00infobox
IKBKGEnsemblENSG000002693351.00infobox
IKBKGEntrez85171.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around IKBKG bring nearby vocabulary together. In this analysis, examples include Gene, Human and Inhibitor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • IKBKG
    • Gene
    • Human
    • Inhibitor
    • Protein
    • Nemo
    • Chromosome
    • Kinase
    • Subunit
    • Location
    • Regulatory
    • Band
    • Bp
  • ikbkg
    • Gene
    • Human
    • Inhibitor
    • Protein
    • Nemo
    • Chromosome
    • Kinase
    • Subunit
    • Location
    • Regulatory
    • Band
    • Bp
  • gene
    • Ikbkg
    • Chromosome
    • Human
    • Nemo
    • Expression
    • Inhibitor
    • Location
    • Band
    • Bp
    • Chr
    • Kinase
    • Subunit
  • iκb kinase
    • Activates
    • Iκb
    • Kinase
    • Genes
    • Subunit
    • Complex
    • Ikk-γ
    • Location
    • Protein
    • Binding
    • Ikk
    • Regulatory
  • nf-κb
    • Activation
    • Activity
    • Ikk
    • Genes
    • Inflammation
    • Binding
    • Subunit
    • Nbd
    • Domain
    • Peptide
    • Regulatory
    • Shown
  • nemo deficiency syndrome
    • Binding
    • Gene
    • Subunit
    • Ikbkg
    • Complex
    • Nbd
    • Domain
    • Expression
    • Ikk-α
    • Region
    • Regulatory
    • Ikk-β
  • protein
    • Human
    • Subunit
    • Activates
    • Domain
    • Expression
    • Genes
    • Iκb
    • Location
    • Mouse
    • Regulatory
    • Activation
    • Activity
  • genes
    • Ikk
    • Iκb
    • Ikk-γ
    • Kinase
    • Nf-κb
    • Inhibitor
    • Location
    • Protein
    • Ikk-α
    • Mouse
    • Regulatory
    • Peptide

Connections between topic areas Semantic bridges

For IKBKG, one of the stronger structural bridges in this analysis connects IKBKG with As a drug target. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IKBKGAs a drug target · splits 26 ⟂ 28
IKBKGInteractions · splits 41 ⟂ 13
IKBKGOverview · splits 48 ⟂ 6
IKBKGClinical significance · splits 48 ⟂ 6

Map overview Semantic statistics

IKBKG

Nodes54
Edges53
Triples135
Avg. degree1.96
Density0.037037
Components1

Source & methodology

TTTA analyzes the structure around IKBKG to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Music, Regions & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IKBKG · EN edition · Analysis: TopicsToTalkAbout

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