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Gabapentinoid

Gabapentinoids, also known as α2δ ligands, are a class of drugs that are chemically derivatives of the inhibitory neurotransmitter gamma-Aminobutyric acid (GABA) (i.e., GABA analogues) which bind selectively to the α2δ protein that was first described as an auxiliary subunit of voltage-gated calcium channels (VGCCs).

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ATC code
N03AX
Biological target
α2δ subunit-containing VDCCsTooltip voltage-dependent calcium channels
Synonyms
α2δ ligands; Ca2+ α2δ ligands
Use
Epilepsy, Neuropathic pain, Postherpetic neuralgia, Diabetic neuropathy, Fibromyalgia, Generalized anxiety disorder, Muscle Relaxant, Restless legs syndrome

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Chemistry

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Map overview Semantic statistics

Gabapentinoid

Nodes153
Edges152
Triples68
Avg. degree1.99
Density0.013072
Components1

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Gabapentinoid

Top relations

related to Recreational use · 20
Gabapentinoid → As, Australia, Because, Canada, Class, Drugs Act, Drugs Regulations, GABAergic, Gabapentinoids, GHB, However, In, In April, Misuse, More, Schedule, The, Tolerance, United Kingdom, United States
related to Pharmacodynamics · 10
Gabapentinoid → All, Gabapentinoids, However, In, NMDA-type, Recently, The, There, VGCC, VGCCs
related to Chemistry · 8
Gabapentinoid → Cache, GABA, L-leucine, PDB, Recently, Specifically, The, These
related to Medical uses · 6
Gabapentinoid → Existing, Gabapentinoids, Heart, In, Some, The
ATC code · 1
Gabapentinoid → N03AX
Biological target · 1
Gabapentinoid → α2δ subunit-containing VDCCsTooltip voltage-dependent calcium channels
Synonyms · 1
Gabapentinoid → α2δ ligands; Ca2+ α2δ ligands
Use · 1
Gabapentinoid → Epilepsy, Neuropathic pain, Postherpetic neuralgia, Diabetic neuropathy, Fibromyalgia, Generalized anxiety disorder, Muscle Relaxant, Restless legs syndrome

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Important terminology

gabapentin pregabalin gabapentinoids phenibut α2δ baclofen approved use treatment drugs bioavailability united enacarbil also mg states subunit oral tmax ligands

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GabapentinoidATC codeN03AX1.00infobox
GabapentinoidBiological targetα2δ subunit-containing VDCCsTooltip voltage-dependent calcium channels1.00infobox
GabapentinoidSynonymsα2δ ligands; Ca2+ α2δ ligands1.00infobox
GabapentinoidUseEpilepsy, Neuropathic pain, Postherpetic neuralgia, Diabetic neuropathy, Fibromyalgia, Generalized anxiety disorder, Muscle Relaxant, Restless legs syndrome1.00infobox
presynaptic NMDA-type glutamate receptorsinstance ofthe same α2δ-1 protein has been found closely associated not with VGCCs but with other proteins0.80text
cell adhesion molecules such as thrombospondininstance ofthe same α2δ-1 protein has been found closely associated not with VGCCs but with other proteins0.80text
othersinstance ofthe same α2δ-1 protein has been found closely associated not with VGCCs but with other proteins0.80text
gabapentininstance ofgabapentinoids0.80text
but not pregabalininstance ofgabapentinoids0.80text
have been found to activate Kv voltage-gated potassium channelsinstance ofgabapentinoids0.80text
L-leucineinstance ofa transporter for amino acids0.80text
L-phenylalanineinstance ofa transporter for amino acids0.80text

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