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Naloxone: History, Community, Culture & Applications

Naloxone, sold under the brand name Narcan among others, is an opioid antagonist, a medication used to reverse or reduce the effects of opioids. Naloxone is commonly used to restore breathing after an opioid overdose. Effects begin within two minutes when given intravenously, five minutes when injected into a muscle, and ten minutes as a nasal spray.…

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Naloxone topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Naloxone.

Related topics
110
Source areas
8
Connected nodes
118
Extracted relationships
136
Concept neighborhoods
25
Bridge connections
118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 30 topics
Society and culture · 24 topics
Pharmacology · 16 topics
Medical uses · 15 topics
Chemistry · 13 topics
Side effects · 6 topics
Veterinary use · 4 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A06AH04 (WHO) V03AB15 (WHO)
Bioavailability
2% (by mouth, 90% absorption but high first-pass metabolism) 43–54% (intranasal) 98% (intramuscular, subcutaneous)
CAS Number
465-65-6 Y
ChEBI
CHEBI:7459 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Society and culture

Veterinary use

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Naloxone connects Entity context

The extracted context around Naloxone shows recurring relationship patterns in the source. For example, Naloxone → Brand, British Approved Name, December, Denominazione Comune Italiana, Dénomination Commune Française, Evzio, Japanese Accepted Name, Kloxxado, Modified, Nalone, Narcan, Narcanti, Narcotan, Prenoxad Injection, Several, Teva, The, United States Adopted Name, Zimhi Another extracted example is Naloxone → March, MedlinePlus, Mental Health Services Administration, Naloxone Nasal Spray, OORM, Opioid Overdose Reversal Medications, SAMHSA, Substance Abuse. Use these groups to spot repeated connection types before inspecting the individual relationships.

Naloxone

Top relations

related to Names · 19
Naloxone → Brand, British Approved Name, December, Denominazione Comune Italiana, Dénomination Commune Française, Evzio, Japanese Accepted Name, Kloxxado, Modified, Nalone, Narcan, Narcanti, Narcotan, Prenoxad Injection, Several, Teva, The, United States Adopted Name, Zimhi
related to External links · 8
Naloxone → March, MedlinePlus, Mental Health Services Administration, Naloxone Nasal Spray, OORM, Opioid Overdose Reversal Medications, SAMHSA, Substance Abuse
Legal status · 7
Naloxone → AU: S4 (Prescription only) / S3 (Pharmacist Only Medicine), BR: Class C1 (Other controlled substances), CA: OTC, DE: § 48 AMG/§ 1 MPAV (Prescription only), In general: ℞ (Prescription only), UK: POM (Prescription only), US: OTC / Rx-only
related to Pharmacodynamics · 7
Naloxone → DOR, If, In, KOR, MOR, Naloxone's, The
related to Clonidine overdose · 6
Naloxone → As, Case, Clonidine, However, Still, The
related to history · 6
Naloxone → It, Jack Fishman, Lewenstein, Mozes, Sankyo, United States
related to Legal status and availability to law enforcement and emergency personnel · 5
Naloxone → European Union, In, Nyxoid, September, United States
related to Preventing recreational opioid use · 5
Naloxone → However, If, SAMHSA's, Suboxone, This
related to Chemistry · 4
Naloxone → N-allylnoroxymorphone, Opioid, Oxymorphone, The
related to Community access · 4
Naloxone → December, In, The, US

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

opioid overdose opioids use used minutes drug administration nasal effects people states emergency us also may spray doses prescription available

Naloxone relationships Subject–Predicate–Object triples

TTTA extracted 136 structured relationships around Naloxone. Examples in this analysis include Naloxone → 3D model (JSmol) → Interactive image and Naloxone → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Naloxone3D model (JSmol)Interactive image1.00infobox
NaloxoneAHFS/Drugs.comMonograph1.00infobox
NaloxoneATC codeA06AH04 (WHO) V03AB15 (WHO)1.00infobox
NaloxoneBioavailability2% (by mouth, 90% absorption but high first-pass metabolism) 43–54% (intranasal) 98% (intramuscular, subcutaneous)1.00infobox
NaloxoneCAS Number465-65-6 Y1.00infobox
NaloxoneChEBICHEBI:7459 N1.00infobox
NaloxoneChEMBLChEMBL80 Y1.00infobox
NaloxoneChemSpider4447644 Y1.00infobox
NaloxoneCompTox Dashboard (EPA)DTXSID80233491.00infobox
NaloxoneDrug classOpioid antagonist1.00infobox
NaloxoneDrugBankDB01183 Y1.00infobox
NaloxoneDuration of actionINTooltip Intranasal: 30–90 min IVTooltip Intravenous: 45 min IMTooltip Intramuscular: 30–120 min1.00infobox
NaloxoneECHA InfoCard100.006.6971.00infobox
NaloxoneElimination half-life1–1.5 h1.00infobox
NaloxoneExcretionUrine, bile1.00infobox
NaloxoneFormulaC19H21NO41.00infobox
NaloxoneIUPHAR/BPS16381.00infobox
NaloxoneKEGGD08249 Y1.00infobox
NaloxoneKEGGas HCl: D01340 Y1.00infobox
NaloxoneLegal statusAU: S4 (Prescription only) / S3 (Pharmacist Only Medicine)1.00infobox
NaloxoneLegal statusBR: Class C1 (Other controlled substances)1.00infobox
NaloxoneLegal statusCA: OTC1.00infobox
NaloxoneLegal statusDE: § 48 AMG/§ 1 MPAV (Prescription only)1.00infobox
NaloxoneLegal statusUK: POM (Prescription only)1.00infobox
NaloxoneLegal statusUS: OTC / Rx-only1.00infobox
NaloxoneLegal statusIn general: ℞ (Prescription only)1.00infobox
NaloxoneLicense dataUS DailyMed: Naloxone1.00infobox
NaloxoneMedlinePlusa6120221.00infobox
NaloxoneMetabolismLiver1.00infobox
NaloxoneMolar mass327.380 g·mol−11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Naloxone bring nearby vocabulary together. In this analysis, examples include Opioid, Overdose and Opioids. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Naloxone
    • Opioid
    • Overdose
    • Opioids
    • People
    • Use
    • Us
    • Programs
    • States
    • Administration
    • Used
    • Distribution
    • Effects
  • naloxone
    • Opioid
    • Overdose
    • Opioids
    • People
    • Use
    • Us
    • Programs
    • States
    • Administration
    • Used
    • Distribution
    • Effects
  • opioid antagonist
    • Overdose
    • Effects
    • Use
    • Opioids
    • Us
    • Opioid
    • Due
    • Emergency
    • Intranasal
    • Pregnancy
    • Cause
    • Reverse
  • opioids
    • May
    • People
    • Withdrawal
    • Cause
    • Use
    • Pregnancy
    • Prescription
    • Administration
    • Used
    • Drug
    • Intranasal
    • Heart
  • opioid overdose
    • Overdose
    • Emergency
    • Us
    • Use
    • Programs
    • Due
    • Prescription
    • States
    • Drug
    • Opioids
    • Also
    • Cause
  • opioid withdrawal
    • May
    • Cause
    • Overdose
    • Opioids
    • Use
    • Us
    • Administration
    • Due
    • People
    • Emergency
    • Opioid
    • Pregnancy
  • opioid receptor antagonist
    • Overdose
    • Effects
    • Use
    • Opioids
    • Us
    • Opioid
    • Due
    • Emergency
    • Intranasal
    • Pregnancy
    • Cause
    • Reverse
  • intranasal administration
    • Administration
    • Intranasal
    • Dose
    • Cause
    • Minutes
    • Heart
    • Injection
    • Pregnancy
    • Withdrawal
    • Effects
    • Spray
    • Approved

Connections between topic areas Semantic bridges

For Naloxone, one of the stronger structural bridges in this analysis connects Naloxone with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Naloxone — Overview · splits 88 ⟂ 31
Naloxone — Society and culture · splits 94 ⟂ 25
Naloxone — Pharmacology · splits 102 ⟂ 17
Naloxone — Medical uses · splits 103 ⟂ 16
Naloxone — Chemistry · splits 105 ⟂ 14
Naloxone — Side effects · splits 112 ⟂ 7
Naloxone — Veterinary use · splits 114 ⟂ 5
Naloxone — History · splits 116 ⟂ 3

Map overview Semantic statistics

Naloxone

Nodes119
Edges118
Triples136
Avg. degree1.98
Density0.016807
Components1

Source & methodology

TTTA analyzes the structure around Naloxone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Naloxone · EN edition · Analysis: TopicsToTalkAbout

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