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Paracetamol: History, Community, Culture & Applications

Paracetamol, or acetaminophen, is an analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold generically or under various brand names, including Tylenol and Panadol.

Language: English [EN]
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Paracetamol topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Paracetamol. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
236
Source areas
11
Connected nodes
248
Extracted relationships
221
Concept neighborhoods
49
Bridge connections
248

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 62 topics
Pharmacology · 36 topics
History · 29 topics
Adverse effects · 21 topics
Society and culture · 20 topics
Interactions · 18 topics
Medical uses · 17 topics
Overdose · 17 topics
Use in pregnancy and breastfeeding · 9 topics
Veterinary use · 6 topics
Chemistry · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N02BE01 (WHO) N02BE51 (WHO) N02BE71 (WHO)
Bioavailability
63–89%: 73
CAS Number
103-90-2
ChEBI
CHEBI:46195

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Use in pregnancy and breastfeeding

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Veterinary use

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Paracetamol connects Entity context

The extracted context around Paracetamol shows recurring relationship patterns in the source. For example, Paracetamol → According, After, American, Drug Administration, FDA, Food, French, Gastrointestinal, However, Hypotension, In, Increase, Intravenous, IV, Johnson, Other, Rechallenge, Stevens Another extracted example is Paracetamol → ADHD, Drug Administration, EMA, European Medicines Agency, FDA, Food, Healthcare, However, In, Large, Medicines, MHRA, Regulatory, Regulatory Agency, Some, Untreated, WHO, World Health Organization. Use these groups to spot repeated connection types before inspecting the individual relationships.

Paracetamol

Top relations

has effect · 18
Paracetamol → According, After, American, Drug Administration, FDA, Food, French, Gastrointestinal, However, Hypotension, In, Increase, Intravenous, IV, Johnson, Other, Rechallenge, Stevens
related to Pregnancy · 18
Paracetamol → ADHD, Drug Administration, EMA, European Medicines Agency, FDA, Food, Healthcare, However, In, Large, Medicines, MHRA, Regulatory, Regulatory Agency, Some, Untreated, WHO, World Health Organization
related to history · 17
Paracetamol → Acetanilide, Antifebrin, Bayer, But, Cahn, Charles Gerhardt, Fe3, French, Harmon Northrop Morse, Hepp, In, Johns Hopkins University, Joseph, Mering, Some, The, Von Mering
related to Naming · 15
Paracetamol → APAP, Australian Approved Name, Both, British Approved Name, Canadian, Co, Frederick Stearns, Japanese Accepted Name, McNeil Laboratories, N-acetyl-p-aminophenol, The, United States, United States Adopted Name, WHO, World Health Organization
related to Available forms · 11
Paracetamol → Another, As, Australia, BAN, British Approved Name, February, In, Intravenous, Ofirmev, Panadeine, United States
related to Interactions · 11
Paracetamol → By, Cmax, Medications, NAPQI, On, Out, Pharmacokinetics, Prokinetic, St John's, The, There
related to Pharmacodynamics · 10
Paracetamol → AM404, CNS, COX, COX-1, COX-2, N-arachidonoylphenolamine, NSAIDs, Supporting, This, Under
related to Pharmacokinetics · 9
Paracetamol → After, Food, Furthermore, In, Its, Paracetamol's, Protein, The, Thus
related to Fever · 7
Paracetamol → As, For, However, In, It, Overall, The
Solubility in water · 6
Paracetamol → 10.97 g/kg (15 °C), 12.78 g/kg (20 °C), 7.21 g/kg (0 °C), 8.21 g/kg (5 °C), 9.44 g/kg (10 °C), ~14 mg/ml (20 °C)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pain liver use used ibuprofen may fever drug overdose effects analgesic combination also acute dose available effect treatment toxicity united

Paracetamol relationships Subject–Predicate–Object triples

TTTA extracted 221 structured relationships around Paracetamol. Examples in this analysis include Paracetamol → 3D model (JSmol) → Interactive image and Paracetamol → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Paracetamol3D model (JSmol)Interactive image1.00infobox
ParacetamolAHFS/Drugs.comMonograph1.00infobox
ParacetamolATC codeN02BE01 (WHO) N02BE51 (WHO) N02BE71 (WHO)1.00infobox
ParacetamolBioavailability63–89%: 731.00infobox
ParacetamolCAS Number103-90-21.00infobox
ParacetamolChEBICHEBI:461951.00infobox
ParacetamolChEMBLChEMBL1121.00infobox
ParacetamolChemSpider19061.00infobox
ParacetamolCompTox Dashboard (EPA)DTXSID20200061.00infobox
ParacetamolDensity1.293 g/cm31.00infobox
ParacetamolDrug classAnalgesic;1.00infobox
ParacetamolDrug classantipyretic1.00infobox
ParacetamolDrugBankDB003161.00infobox
ParacetamolECHA InfoCard100.002.8701.00infobox
ParacetamolElimination half-life1.9–2.5 hours1.00infobox
ParacetamolExcretionKidney1.00infobox
ParacetamolFormulaC8H9NO21.00infobox
ParacetamolIUPHAR/BPS52391.00infobox
ParacetamolKEGGD002171.00infobox
ParacetamolLegal statusAU: S4 (Prescription only) OTC, and unscheduled1.00infobox
ParacetamolLegal statusCA: OTC / Rx-only1.00infobox
ParacetamolLegal statusUK: General sales list (GSL, OTC)1.00infobox
ParacetamolLegal statusUS: OTC / Rx-only1.00infobox
ParacetamolLegal statusCN: OTC1.00infobox
ParacetamolLicense dataUS DailyMed: Acetaminophen1.00infobox
ParacetamolMedlinePlusa6810041.00infobox
ParacetamolMelting point169 °C (336 °F)1.00infobox
ParacetamolMetabolismPredominantly in the liver1.00infobox
ParacetamolMetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, AM404, NAPQI1.00infobox
ParacetamolMolar mass151.165 g·mol−11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Paracetamol bring nearby vocabulary together. In this analysis, examples include Pain, Use and Used. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Paracetamol
    • Pain
    • Use
    • Used
    • Liver
    • Effects
    • Combination
    • Ibuprofen
    • May
    • Clinical
    • Treatment
    • Fever
    • Effective
  • paracetamol
    • Pain
    • Use
    • Used
    • Liver
    • Effects
    • Combination
    • Ibuprofen
    • May
    • Clinical
    • Treatment
    • Fever
    • Effective
  • analgesic
    • Antipyretic
    • Drug
    • Am404
    • Used
    • Fever
    • Combination
    • May
    • Paracetamol
    • Use
    • Intravenous
    • Tylenol
    • Codeine
  • fever
    • Pain
    • Used
    • Tylenol
    • Drugs
    • Patients
    • Treatment
    • Drug
    • May
    • Liver
    • Paracetamol
    • Use
    • Intravenous
  • pain
    • Acute
    • Ibuprofen
    • Paracetamol
    • Effective
    • Use
    • Used
    • Treatment
    • Effects
    • Drugs
    • Combination
    • Intravenous
    • Tylenol
  • combination of paracetamol and ibuprofen
    • Codeine
    • Effective
    • Pain
    • Combination
    • Ibuprofen
    • Use
    • Effects
    • Used
    • Drugs
    • Liver
    • Treatment
    • Paracetamol
  • cancer pain
    • Acute
    • Ibuprofen
    • Paracetamol
    • Effective
    • Use
    • Used
    • Treatment
    • Effects
    • Drugs
    • Combination
    • Intravenous
    • Tylenol
  • neuropathic pain
    • Acute
    • Ibuprofen
    • Paracetamol
    • Effective
    • Use
    • Used
    • Treatment
    • Effects
    • Drugs
    • Combination
    • Intravenous
    • Tylenol

Connections between topic areas Semantic bridges

For Paracetamol, one of the stronger structural bridges in this analysis connects Paracetamol with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ParacetamolOverview · splits 186 ⟂ 63
ParacetamolPharmacology · splits 212 ⟂ 37
ParacetamolHistory · splits 219 ⟂ 30
ParacetamolAdverse effects · splits 227 ⟂ 22
ParacetamolSociety and culture · splits 228 ⟂ 21
ParacetamolInteractions · splits 230 ⟂ 19
ParacetamolMedical uses · splits 231 ⟂ 18
ParacetamolOverdose · splits 231 ⟂ 18
ParacetamolUse in pregnancy and breastfeeding · splits 239 ⟂ 10
ParacetamolVeterinary use · splits 242 ⟂ 7
ParacetamolChemistry · splits 246 ⟂ 3

Map overview Semantic statistics

Paracetamol

Nodes249
Edges248
Triples221
Avg. degree1.99
Density0.008032
Components1

Source & methodology

TTTA analyzes the structure around Paracetamol to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Paracetamol · EN edition · Analysis: TopicsToTalkAbout

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