NCK2

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Explore the main themes, entities and connections around NCK2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Adaptor proteins NCK1 SH3 domains SH2 domain Catalytic

10 related topics

Interactions

Interact Epidermal growth factor receptor LIMS1 PDGFRB PTK2

7 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: NCK2, GRB4, NCKbeta, NCK adaptor protein 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U5S, 1WX6, 1Z3K, 2B86, 2CIA, 2FRW, 2FRY, 2JXB, 4E6R
Band: 2q12.2 · 1|1 C1.1
Bgee: hair follicle · parotid gland · secondary oocyte · Region I of hippocampus proper · ganglionic eminence
BioGPS: n/a
Chr.: Chromosome 2 (human) · Chromosome 1 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Adaptor proteins Signal transducing adaptor protein
NCK1
SH3 domains SH3 domain
SH2 domain
Catalytic Catalysis
Receptor protein tyrosine kinases Receptor protein tyrosine kinase
Cytoskeletal Cytoskeleton
Transcriptional
Splice variants RNA splicing
Isoforms Isoform

Interactions

Interact Protein-protein interaction
Epidermal growth factor receptor
LIMS1
PDGFRB
PTK2
T-cell surface glycoprotein CD3 epsilon chain
TrkB

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes23

Edges22

Triples117

Avg. degree1.91

Density0.086957

Components1

How this topic connects Entity context

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NCK2

Top relations

Gene ontology · 35

NCK2 → actin filament organization, cell migration, cytoplasm, cytoskeletal anchor activity, cytosol, dendritic spine development, endoplasmic reticulum, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway, immunological synapse formation, lamellipodium assembly, negative regulation of cell population proliferation, negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, negative regulation of peptidyl-serine phosphorylation, negative regulation of PERK-mediated unfolded protein response, negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, phosphotyrosine residue binding, positive regulation of actin filament polymerization, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of T cell proliferation

Bgee · 20

NCK2 → cartilage tissue, dentate gyrus of hippocampal formation granule cell, duodenum, ganglionic eminence, gastric mucosa, genital tubercle, gums, hair follicle, lip, olfactory zone of nasal mucosa, parotid gland, primary visual cortex, Region I of hippocampus proper, right kidney, secondary oocyte, spermatid, tail of embryo, thymus, ventricular zone, yolk sac

RNA expression pattern · 20

related to Function · 8

NCK2 → Alternate, It, NCK, NCK1, SH2, SH3, The, There

related to Interactions · 6

NCK2 → CD3, Epidermal, LIMS1, PDGFRB, PTK2, T-cell

related to External links · 4

NCK2 → Cell Migration Gateway Archived, Nck2 Archived, Wayback Machine, Wayback Machine Info

Band · 2

NCK2 → 1|1 C1.1, 2q12.2

Chr. · 2

NCK2 → Chromosome 1 (mouse), Chromosome 2 (human)

End · 2

NCK2 → 105,894,274 bp, 43,609,675 bp

Aliases · 1

NCK2 → NCK2, GRB4, NCKbeta, NCK adaptor protein 2

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp protein chr human band chromosome gene location function adaptor mouse nck receptor grb4 external known search 894 274 end

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
NCK2	Aliases	NCK2, GRB4, NCKbeta, NCK adaptor protein 2	1.00	infobox
NCK2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U5S, 1WX6, 1Z3K, 2B86, 2CIA, 2FRW, 2FRY, 2JXB, 4E6R	1.00	infobox
NCK2	Band	2q12.2	1.00	infobox
NCK2	Band	1\|1 C1.1	1.00	infobox
NCK2	Bgee	hair follicle	1.00	infobox
NCK2	Bgee	parotid gland	1.00	infobox
NCK2	Bgee	secondary oocyte	1.00	infobox
NCK2	Bgee	Region I of hippocampus proper	1.00	infobox
NCK2	Bgee	ganglionic eminence	1.00	infobox
NCK2	Bgee	cartilage tissue	1.00	infobox
NCK2	Bgee	duodenum	1.00	infobox
NCK2	Bgee	olfactory zone of nasal mucosa	1.00	infobox
NCK2	Bgee	gums	1.00	infobox
NCK2	Bgee	gastric mucosa	1.00	infobox
NCK2	Bgee	dentate gyrus of hippocampal formation granule cell	1.00	infobox
NCK2	Bgee	ventricular zone	1.00	infobox
NCK2	Bgee	thymus	1.00	infobox
NCK2	Bgee	lip	1.00	infobox
NCK2	Bgee	tail of embryo	1.00	infobox
NCK2	Bgee	yolk sac	1.00	infobox
NCK2	Bgee	primary visual cortex	1.00	infobox
NCK2	Bgee	spermatid	1.00	infobox
NCK2	Bgee	right kidney	1.00	infobox
NCK2	Bgee	genital tubercle	1.00	infobox
NCK2	BioGPS	n/a	1.00	infobox
NCK2	Chr.	Chromosome 2 (human)	1.00	infobox
NCK2	Chr.	Chromosome 1 (mouse)	1.00	infobox
NCK2	Databases	NCBI: entry; OMA: entry	1.00	infobox
NCK2	End	105,894,274 bp	1.00	infobox
NCK2	End	43,609,675 bp	1.00	infobox

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