Caspase 3

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Caspase 3 topic overview

The analysis highlights Overview, Enzymatic activity and Function as prominent areas in the source structure around Caspase 3.

Related topics: 61
Source areas: 6
Connected nodes: 67
Extracted relationships: 151
Concept neighborhoods: 23
Bridge connections: 67

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 23 topics

Enzymatic activity · 10 topics

Function · 9 topics

Interactions · 9 topics

Regulation · 8 topics

Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.22.56: ↗
Aliases: CASP3, CPP32, CPP32B, SCA-1, caspase 3
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,…
Band: 8 B1.1|8 26.39 cM
Bgee: medial ganglionic eminence · barrel cortex · Rostral migratory stream · neural tube · trigeminal ganglion
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Caspase
Caspase-8
Caspase-9
Orthologs
Mammals Mammal
Birds Bird
Lizards Lizard
Lissamphibians Lissamphibian
Teleosts Teleost
Protein
Cell apoptosis Apoptosis
Proenzymes Proenzyme
Enzyme
Caspases 6 Caspase 6
10 Caspase 10
Amyloid-beta 4A precursor protein Early-onset Alzheimer's disease
Alzheimer's disease
Cysteine
Histidine
Peptide bond
Aspartic acid
Glutamic acid
Zymogens

Structure

Function

Enzymatic activity

Regulation

Interactions

Interact Protein-protein interaction
NMT2
CFLAR
DCC Deleted in Colorectal Cancer
GroEL
HCLS1
Survivin
TRAF3
NFE2L2

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Caspase 3 connects Entity context

The extracted context around Caspase 3 shows recurring relationship patterns in the source. For example, Caspase 3 → activation of cysteine-type endopeptidase activity involved in apoptotic process, anterior neural tube closure, apoptotic DNA fragmentation, apoptotic process, apoptotic signaling pathway, aspartic-type endopeptidase activity, axonal fasciculation, B cell homeostasis, cell fate commitment, cellular response to DNA damage stimulus, cellular response to organic cyclic compound, cellular response to organic substance, cellular response to staurosporine, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity Another extracted example is Caspase 3 → Apaf-1, As, ATP, B-amyloid, Caspase-3, Garcinia, In, Mangosteen, One, The, These, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 86

Caspase 3 → activation of cysteine-type endopeptidase activity involved in apoptotic process, anterior neural tube closure, apoptotic DNA fragmentation, apoptotic process, apoptotic signaling pathway, aspartic-type endopeptidase activity, axonal fasciculation, B cell homeostasis, cell fate commitment, cellular response to DNA damage stimulus, cellular response to organic cyclic compound, cellular response to organic substance, cellular response to staurosporine, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity

related to Activation · 12

Caspase 3 → Apaf-1, As, ATP, B-amyloid, Caspase-3, Garcinia, In, Mangosteen, One, The, These, This

Bgee · 10

Caspase 3 → barrel cortex, epiblast, granulocyte, medial ganglionic eminence, neural tube, renal corpuscle, Rostral migratory stream, superior cervical ganglion, tail of embryo, trigeminal ganglion

RNA expression pattern · 10

Caspase 3 → barrel cortex, epiblast, granulocyte, medial ganglionic eminence, neural tube, renal corpuscle, Rostral migratory stream, superior cervical ganglion, tail of embryo, trigeminal ganglion

related to External links · 6

Caspase 3 → Archived, C14, Caspase, The MEROPS, The Proteolysis Map-animation, Wayback MachineApoptosis

related to Substrate specificity · 4

Caspase 3 → Asp-x-x-Asp, Caspase, The C-terminal Asp, Under

related to Interactions · 2

Caspase 3 → CASP8NMT2CFLARDCCGroELHCLS1SurvivinTRAF3XIAPNFE2L2, Caspase

3.4.22.56 · 1

Caspase 3 → ↗

Aliases · 1

Caspase 3 → CASP3, CPP32, CPP32B, SCA-1, caspase 3

Available structures · 1

Caspase 3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

caspase-3 caspase protein caspases activation cell activity casp3 apoptosis acid apoptotic active aspartic caspase-9 gene orthologs role site cys-163 cleavage

Caspase 3 relationships Subject–Predicate–Object triples

TTTA extracted 151 structured relationships around Caspase 3. Examples in this analysis include Caspase 3 → 3.4.22.56 → ↗ and Caspase 3 → Aliases → CASP3, CPP32, CPP32B, SCA-1, caspase 3. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Caspase 3	3.4.22.56	↗	1.00	infobox
Caspase 3	Aliases	CASP3, CPP32, CPP32B, SCA-1, caspase 3	1.00	infobox
Caspase 3	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M,…	1.00	infobox
Caspase 3	Band	8 B1.1\|8 26.39 cM	1.00	infobox
Caspase 3	Bgee	medial ganglionic eminence	1.00	infobox
Caspase 3	Bgee	barrel cortex	1.00	infobox
Caspase 3	Bgee	Rostral migratory stream	1.00	infobox
Caspase 3	Bgee	neural tube	1.00	infobox
Caspase 3	Bgee	trigeminal ganglion	1.00	infobox
Caspase 3	Bgee	renal corpuscle	1.00	infobox
Caspase 3	Bgee	granulocyte	1.00	infobox
Caspase 3	Bgee	tail of embryo	1.00	infobox
Caspase 3	Bgee	epiblast	1.00	infobox
Caspase 3	Bgee	superior cervical ganglion	1.00	infobox
Caspase 3	BioGPS	More reference expression data	1.00	infobox
Caspase 3	Chr.	Chromosome 8 (mouse)	1.00	infobox
Caspase 3	Databases	NCBI: entry; OMA: entry	1.00	infobox
Caspase 3	End	47,092,724 bp	1.00	infobox
Caspase 3	Ensembl	ENSG00000164305	1.00	infobox
Caspase 3	Entrez	836	1.00	infobox
Caspase 3	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc3.4.22.56↗↗↗↗	1.00	infobox
Caspase 3	External IDs	OMIM: 600636; MGI: 107739; GeneCards: CASP3	1.00	infobox
Caspase 3	Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 8 (mouse)Band8 B1.1\|8 26.39 cMStart47,070,326 bpEnd47,092,724 bp	1.00	infobox
Caspase 3	Gene ontology	cysteine-type peptidase activity	1.00	infobox
Caspase 3	Gene ontology	peptidase activity	1.00	infobox
Caspase 3	Gene ontology	protein binding	1.00	infobox
Caspase 3	Gene ontology	phospholipase A2 activator activity	1.00	infobox
Caspase 3	Gene ontology	cyclin-dependent protein serine/threonine kinase inhibitor activity	1.00	infobox
Caspase 3	Gene ontology	cysteine-type endopeptidase activity involved in apoptotic process	1.00	infobox
Caspase 3	Gene ontology	cysteine-type endopeptidase activity involved in execution phase of apoptosis	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Caspase 3 bring nearby vocabulary together. In this analysis, examples include Activity, Protein and Specificity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Caspase 3
- Activity
- Protein
- Specificity
- Xiap
- Caspase-3
- Activation
- Inhibitor
- Zymogen
- Casp3
- Caspase-9
- Apoptotic
- Apoptosis
caspase 3
- Activity
- Protein
- Specificity
- Xiap
- Caspase-3
- Activation
- Inhibitor
- Zymogen
- Casp3
- Caspase-9
- Apoptotic
- Apoptosis
caspase
- Activity
- Protein
- Specificity
- Xiap
- Caspase-3
- Activation
- Inhibitor
- Zymogen
- Casp3
- Caspase-9
- Apoptotic
- Apoptosis
cell apoptosis
- Apoptotic
- Activated
- Cellular
- Death
- Dna
- Inactive
- Inhibitor
- Protease
- Function
- Xiap
- Zymogen
- Role
aspartic acid
- Aspartic
- Peptide
- Cleavage
- Protease
- Residue
- Protein
- Caspases
- Casp3
- Active
- Inactive
- Two
- Bp
glutamic acid
- Aspartic
- Peptide
- Protease
- Protein
- Cleavage
- Residue
- Casp3
- Caspases
- Bp
- Chr
- Inhibitor
- Involved
zymogen
- Activity
- Activated
- Cellular
- Dna
- Apoptotic
- Caspase-3
- Cell
- Bp
- Chr
- Inactive
- Inhibitor
- Involved
caspase 7
- Activity
- Protein
- Specificity
- Xiap
- Caspase-3
- Activation
- Inhibitor
- Zymogen
- Casp3
- Caspase-9
- Apoptotic
- Apoptosis

Connections between topic areas Semantic bridges

For Caspase 3, one of the stronger structural bridges in this analysis connects Caspase 3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Caspase 3 — Overview · splits 44 ⟂ 24

Caspase 3 — Enzymatic activity · splits 57 ⟂ 11

Caspase 3 — Function · splits 58 ⟂ 10

Caspase 3 — Interactions · splits 58 ⟂ 10

Caspase 3 — Regulation · splits 59 ⟂ 9

Caspase 3 — Structure · splits 65 ⟂ 3

Map overview Semantic statistics

Caspase 3

Nodes68

Edges67

Triples151

Avg. degree1.97

Density0.029412

Components1

Source & methodology

TTTA analyzes the structure around Caspase 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Enzymatic activity & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Caspase 3 · EN edition · Analysis: TopicsToTalkAbout