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TSC2

Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the TSC2 gene.

Interactions, Function & Cell pathology

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Interactions

16 related topics

Function

9 related topics

Cell pathology

5 related topics

Signaling pathways

4 related topics

Key facts & relationships

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Aliases
TSC2, LAM, PPP1R160, TSC4, tuberous sclerosis 2, TSC complex subunit 2
Band
16p13.3 · 17 A3.3|17 12.41 cM
Bgee
right hemisphere of cerebellum · anterior pituitary · right uterine tube · right lobe of thyroid gland · sural nerve
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 17 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Function

Cell pathology

Signaling pathways

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

TSC2

Nodes42
Edges41
Triples115
Avg. degree1.95
Density0.047619
Components1

How this topic connects Entity context

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TSC2

Top relations

Gene ontology · 40
TSC2 → anoikis, cytoplasm, cytosol, development of the heart, endocytosis, Golgi apparatus, GTPase activator activity, Hsp90 protein binding, insulin-like growth factor receptor signaling pathway, lysosome, membrane, negative regulation of cell population proliferation, negative regulation of insulin receptor signaling pathway, negative regulation of mitophagy, negative regulation of phosphatidylinositol 3-kinase signaling, negative regulation of protein kinase activity, negative regulation of protein kinase B signaling, negative regulation of TOR signaling, negative regulation of Wnt signaling pathway, neural tube closure
Bgee · 20
TSC2 → anterior pituitary, CA3 field, cardiac muscle tissue of left ventricle, dentate gyrus of hippocampal formation granule cell, genital tubercle, left lobe of thyroid gland, left ovary, left testis, muscle of thigh, neural layer of retina, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone
RNA expression pattern · 20
TSC2 → anterior pituitary, CA3 field, cardiac muscle tissue of left ventricle, dentate gyrus of hippocampal formation granule cell, genital tubercle, left lobe of thyroid gland, left ovary, left testis, muscle of thigh, neural layer of retina, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone
related to Function · 8
TSC2 → Alternative, Because, GTPases, Hamartin, Hsp90, Its, Mutations, TSC1
related to Cell pathology · 4
TSC2 → Cells, Defects, LAMP1/2, LC3
related to Interactions · 3
TSC2 → TBC1D7, TSC, TSC1
Band · 2
TSC2 → 16p13.3, 17 A3.3|17 12.41 cM
Chr. · 2
TSC2 → Chromosome 16 (human), Chromosome 17 (mouse)
End · 2
TSC2 → 2,089,491 bp, 24,851,604 bp
Aliases · 1
TSC2 → TSC2, LAM, PPP1R160, TSC4, tuberous sclerosis 2, TSC complex subunit 2

Important terminology Word statistics

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Important terminology

gene bp complex protein chr human band tuberous sclerosis chromosome 16 location cell hsp90 mutations tuberin tsc1 also mouse tsc

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TSC2AliasesTSC2, LAM, PPP1R160, TSC4, tuberous sclerosis 2, TSC complex subunit 21.00infobox
TSC2Band16p13.31.00infobox
TSC2Band17 A3.3|17 12.41 cM1.00infobox
TSC2Bgeeright hemisphere of cerebellum1.00infobox
TSC2Bgeeanterior pituitary1.00infobox
TSC2Bgeeright uterine tube1.00infobox
TSC2Bgeeright lobe of thyroid gland1.00infobox
TSC2Bgeesural nerve1.00infobox
TSC2Bgeeleft lobe of thyroid gland1.00infobox
TSC2Bgeeright testis1.00infobox
TSC2Bgeeleft testis1.00infobox
TSC2Bgeeright frontal lobe1.00infobox
TSC2Bgeeleft ovary1.00infobox
TSC2Bgeetail of embryo1.00infobox
TSC2Bgeegenital tubercle1.00infobox
TSC2Bgeesuperior frontal gyrus1.00infobox
TSC2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
TSC2Bgeeprimary visual cortex1.00infobox
TSC2Bgeeneural layer of retina1.00infobox
TSC2Bgeemuscle of thigh1.00infobox
TSC2Bgeecardiac muscle tissue of left ventricle1.00infobox
TSC2Bgeeventricular zone1.00infobox
TSC2BgeeCA3 field1.00infobox
TSC2BioGPSMore reference expression data1.00infobox
TSC2Chr.Chromosome 16 (human)1.00infobox
TSC2Chr.Chromosome 17 (mouse)1.00infobox
TSC2DatabasesNCBI: entry; OMA: entry1.00infobox
TSC2End2,089,491 bp1.00infobox
TSC2End24,851,604 bp1.00infobox
TSC2EnsemblENSG000001031971.00infobox

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