Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

NEDD9: Gene, Structure & Interactions

Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

NEDD9 topic overview

The analysis highlights Gene, Structure and Interactions as prominent areas in the source structure around NEDD9.

Related topics
84
Source areas
8
Connected nodes
92
Extracted relationships
292
Concept neighborhoods
23
Bridge connections
92

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Gene · 26 topics
Structure · 24 topics
Interactions · 13 topics
Discovery · 8 topics
Protein family · 5 topics
Overview · 4 topics
Synthesis and degradation · 3 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, neural precursor cell expressed, developmentally down-regulated 9
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L81
Band
6p24.2 · 13|13 A3.3- A4
Bgee
right lung · lower lobe of lung · glomerulus · metanephric glomerulus · upper lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 13 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Gene

Protein family

Structure

Synthesis and degradation

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NEDD9 connects Entity context

The extracted context around NEDD9 shows recurring relationship patterns in the source. For example, NEDD9 → actin filament bundle assembly, actin filament reorganization, activation of GTPase activity, cell adhesion, cell cortex, cell cycle, cell division, cell junction, cell migration, cell projection, cytoplasm, cytoskeleton, cytoskeleton organization, cytosol, focal adhesion, Golgi apparatus, integrin-mediated signaling pathway, lamellipodium, nucleoplasm, nucleus Another extracted example is NEDD9 → BCAR1, CAS-L, CAS2, CASL, CASS2, CASS4, EFS, Ensembl, ENSG00000111859, Entrez Gene, GRCh37, GRCh38, HEF1, HEPL, HGNC, HUGO, Human Genome Organization, In, MKYK, MWAR. Use these groups to spot repeated connection types before inspecting the individual relationships.

NEDD9

Top relations

Gene ontology · 30
NEDD9 → actin filament bundle assembly, actin filament reorganization, activation of GTPase activity, cell adhesion, cell cortex, cell cycle, cell division, cell junction, cell migration, cell projection, cytoplasm, cytoskeleton, cytoskeleton organization, cytosol, focal adhesion, Golgi apparatus, integrin-mediated signaling pathway, lamellipodium, nucleoplasm, nucleus
related to Gene · 29
NEDD9 → BCAR1, CAS-L, CAS2, CASL, CASS2, CASS4, EFS, Ensembl, ENSG00000111859, Entrez Gene, GRCh37, GRCh38, HEF1, HEPL, HGNC, HUGO, Human Genome Organization, In, MKYK, MWAR
related to Chemokine receptors, TCR, BCR/ABL, Fyn, Lck kinases · 26
NEDD9 → Abl, AKT, BCAR1, BCR, CAS, Chat-H/SHEP1/NSP3, EGFR, ERK, Estrogen Receptor, Fyn, GTPase RAP1, In, It, Lck, NSLC, NSP, NSP2/BCAR3, NSP3, PDGF, RAP1
related to Integrin, FAK/RAFTK, and SRC kinases · 23
NEDD9 → C3G, Crk, DOCK1, DOCK3 DOCK180, ECM, FAK, GEFs, GTPases, However, In, Integrin, Integrins, N-terminal SH3, NEDD9 Crk, NEDD9 Src-binding, Phosphorylation, RAFTK, Ras, Rho, SH2
Bgee · 20
NEDD9 → caput epididymis, ciliary body, corpus epididymis, cumulus cell, decidua, gastrula, glomerulus, Gonadal ridge, granulocyte, left colon, left lung lobe, lower lobe of lung, metanephric glomerulus, molar, parotid gland, right lung, right lung lobe, tail of epididymis, upper lobe of left lung, upper lobe of lung
RNA expression pattern · 20
NEDD9 → caput epididymis, ciliary body, corpus epididymis, cumulus cell, decidua, gastrula, glomerulus, Gonadal ridge, granulocyte, left colon, left lung lobe, lower lobe of lung, metanephric glomerulus, molar, parotid gland, right lung, right lung lobe, tail of epididymis, upper lobe of left lung, upper lobe of lung
related to Synthesis and degradation · 20
NEDD9 → An, APC, APC10, Aurora-A, C-terminal, CDH1, DDYD, DLVD, G2/M, In, KDa, N-terminal, Overexpression, P115, Proteasomal, Smad3, TGF-beta, TGFbeta, This, Together
related to Aurora-A · 16
NEDD9 → AURKA, Aurora, Aurora-A, Cells, Cilia, CTTN, Degradation, F-actin, G1, HDAC6, Hedgehog, Inhibition, Interaction, On, Overexpression, The
related to Discovery · 14
NEDD9 → Cas-L, Crk-associated, FAK, Filamentation, HEF1, HEF1/NEDD9, Human Enhancer, In, Kumar, Law, Lymphocyte, Minegishi, Separately, This
related to Interactions · 12
NEDD9 → ABL1, AURKA, CDH1, CRK, CRKL, ID2, LYN, MICAL1, NCK1, NSP, PTK2, SMAD3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cell gene cells protein signaling cancer also human family focal src bp binding kinase adhesion based degradation expression migration chr

NEDD9 relationships Subject–Predicate–Object triples

TTTA extracted 292 structured relationships around NEDD9. Examples in this analysis include NEDD9 → Aliases → NEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, neural precursor cell expressed, developmentally down-regulated 9 and NEDD9 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L81. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NEDD9AliasesNEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, neural precursor cell expressed, developmentally down-regulated 91.00infobox
NEDD9Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L811.00infobox
NEDD9Band6p24.21.00infobox
NEDD9Band13|13 A3.3- A41.00infobox
NEDD9Bgeeright lung1.00infobox
NEDD9Bgeelower lobe of lung1.00infobox
NEDD9Bgeeglomerulus1.00infobox
NEDD9Bgeemetanephric glomerulus1.00infobox
NEDD9Bgeeupper lobe of lung1.00infobox
NEDD9Bgeeupper lobe of left lung1.00infobox
NEDD9Bgeetail of epididymis1.00infobox
NEDD9Bgeeparotid gland1.00infobox
NEDD9Bgeecorpus epididymis1.00infobox
NEDD9Bgeecaput epididymis1.00infobox
NEDD9Bgeecumulus cell1.00infobox
NEDD9Bgeeleft lung lobe1.00infobox
NEDD9BgeeGonadal ridge1.00infobox
NEDD9Bgeegranulocyte1.00infobox
NEDD9Bgeeright lung lobe1.00infobox
NEDD9Bgeedecidua1.00infobox
NEDD9Bgeegastrula1.00infobox
NEDD9Bgeeleft colon1.00infobox
NEDD9Bgeemolar1.00infobox
NEDD9Bgeeciliary body1.00infobox
NEDD9BioGPSMore reference expression data1.00infobox
NEDD9Chr.Chromosome 6 (human)1.00infobox
NEDD9Chr.Chromosome 13 (mouse)1.00infobox
NEDD9DatabasesNCBI: entry; OMA: entry1.00infobox
NEDD9End11,382,348 bp1.00infobox
NEDD9End41,640,838 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NEDD9 bring nearby vocabulary together. In this analysis, examples include Cells, Signaling and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NEDD9
    • Cells
    • Signaling
    • Cancer
    • Protein
    • Adhesion
    • Binding
    • Kinase
    • Also
    • Response
    • Based
    • Family
    • Focal
  • nedd9
    • Cells
    • Signaling
    • Cancer
    • Protein
    • Adhesion
    • Binding
    • Kinase
    • Also
    • Response
    • Based
    • Family
    • Focal
  • gene
    • Location
    • Human
    • Protein
    • Bp
    • Chr
    • Band
    • Cas-l
    • Based
    • Bcar1
    • Nedd9
    • Fak
    • Tgf-beta
  • neural precursor cell
    • Protein
    • Nedd9
    • Cells
    • Integrin
    • Migration
    • Adhesion
    • Gene
    • Expressed
    • Cancer
    • Activation
    • Regulates
    • Signaling
  • focal adhesion kinase
    • Focal
    • Activation
    • Integrin
    • Migration
    • Kinase
    • Fak
    • Signaling
    • Response
    • Cell
    • Cells
    • Protein
    • Band
  • colon cancer
    • Expression
    • Nedd9
    • Cell
    • Tgf-beta
    • Activity
    • Regulates
    • Role
    • Signaling
    • Cells
    • Binding
    • Protein
    • Cas-l
  • src family kinases
    • Member
    • Src
    • Protein
    • Phosphorylation
    • Integrin
    • Migration
    • Tgf-beta
    • Bcar1
    • Study
    • Bp
    • Chr
    • Fak
  • focal adhesion
    • Focal
    • Activation
    • Integrin
    • Migration
    • Kinase
    • Fak
    • Signaling
    • Response
    • Cell
    • Cells
    • Protein
    • Band

Connections between topic areas Semantic bridges

For NEDD9, one of the stronger structural bridges in this analysis connects NEDD9 with Gene. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NEDD9Gene · splits 66 ⟂ 27
NEDD9Structure · splits 68 ⟂ 25
NEDD9Interactions · splits 79 ⟂ 14
NEDD9Discovery · splits 84 ⟂ 9
NEDD9Protein family · splits 87 ⟂ 6
NEDD9Overview · splits 88 ⟂ 5
NEDD9Synthesis and degradation · splits 89 ⟂ 4

Map overview Semantic statistics

NEDD9

Nodes93
Edges92
Triples292
Avg. degree1.98
Density0.021505
Components1

Source & methodology

TTTA analyzes the structure around NEDD9 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Gene, Structure & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NEDD9 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.