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NEDD9

Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.

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Aliases
NEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, neural precursor cell expressed, developmentally down-regulated 9
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L81
Band
6p24.2 · 13|13 A3.3- A4
Bgee
right lung · lower lobe of lung · glomerulus · metanephric glomerulus · upper lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 13 (mouse)

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Overview

Discovery

Gene

Protein family

Structure

Synthesis and degradation

Clinical significance

Interactions

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Map overview Semantic statistics

NEDD9

Nodes93
Edges92
Triples292
Avg. degree1.98
Density0.021505
Components1

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NEDD9

Top relations

Gene ontology · 30
NEDD9 → actin filament bundle assembly, actin filament reorganization, activation of GTPase activity, cell adhesion, cell cortex, cell cycle, cell division, cell junction, cell migration, cell projection, cytoplasm, cytoskeleton, cytoskeleton organization, cytosol, focal adhesion, Golgi apparatus, integrin-mediated signaling pathway, lamellipodium, nucleoplasm, nucleus
related to Gene · 29
NEDD9 → BCAR1, CAS-L, CAS2, CASL, CASS2, CASS4, EFS, Ensembl, ENSG00000111859, Entrez Gene, GRCh37, GRCh38, HEF1, HEPL, HGNC, HUGO, Human Genome Organization, In, MKYK, MWAR
related to Chemokine receptors, TCR, BCR/ABL, Fyn, Lck kinases · 26
NEDD9 → Abl, AKT, BCAR1, BCR, CAS, Chat-H/SHEP1/NSP3, EGFR, ERK, Estrogen Receptor, Fyn, GTPase RAP1, In, It, Lck, NSLC, NSP, NSP2/BCAR3, NSP3, PDGF, RAP1
related to Integrin, FAK/RAFTK, and SRC kinases · 23
NEDD9 → C3G, Crk, DOCK1, DOCK3 DOCK180, ECM, FAK, GEFs, GTPases, However, In, Integrin, Integrins, N-terminal SH3, NEDD9 Crk, NEDD9 Src-binding, Phosphorylation, RAFTK, Ras, Rho, SH2
Bgee · 20
NEDD9 → caput epididymis, ciliary body, corpus epididymis, cumulus cell, decidua, gastrula, glomerulus, Gonadal ridge, granulocyte, left colon, left lung lobe, lower lobe of lung, metanephric glomerulus, molar, parotid gland, right lung, right lung lobe, tail of epididymis, upper lobe of left lung, upper lobe of lung
RNA expression pattern · 20
NEDD9 → caput epididymis, ciliary body, corpus epididymis, cumulus cell, decidua, gastrula, glomerulus, Gonadal ridge, granulocyte, left colon, left lung lobe, lower lobe of lung, metanephric glomerulus, molar, parotid gland, right lung, right lung lobe, tail of epididymis, upper lobe of left lung, upper lobe of lung
related to Synthesis and degradation · 20
NEDD9 → An, APC, APC10, Aurora-A, C-terminal, CDH1, DDYD, DLVD, G2/M, In, KDa, N-terminal, Overexpression, P115, Proteasomal, Smad3, TGF-beta, TGFbeta, This, Together
related to Aurora-A · 16
NEDD9 → AURKA, Aurora, Aurora-A, Cells, Cilia, CTTN, Degradation, F-actin, G1, HDAC6, Hedgehog, Inhibition, Interaction, On, Overexpression, The
related to Discovery · 14
NEDD9 → Cas-L, Crk-associated, FAK, Filamentation, HEF1, HEF1/NEDD9, Human Enhancer, In, Kumar, Law, Lymphocyte, Minegishi, Separately, This
related to Interactions · 12
NEDD9 → ABL1, AURKA, CDH1, CRK, CRKL, ID2, LYN, MICAL1, NCK1, NSP, PTK2, SMAD3

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Important terminology

cell gene cells protein signaling cancer also human family focal src bp binding kinase adhesion based degradation expression migration chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NEDD9AliasesNEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, neural precursor cell expressed, developmentally down-regulated 91.00infobox
NEDD9Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L811.00infobox
NEDD9Band6p24.21.00infobox
NEDD9Band13|13 A3.3- A41.00infobox
NEDD9Bgeeright lung1.00infobox
NEDD9Bgeelower lobe of lung1.00infobox
NEDD9Bgeeglomerulus1.00infobox
NEDD9Bgeemetanephric glomerulus1.00infobox
NEDD9Bgeeupper lobe of lung1.00infobox
NEDD9Bgeeupper lobe of left lung1.00infobox
NEDD9Bgeetail of epididymis1.00infobox
NEDD9Bgeeparotid gland1.00infobox
NEDD9Bgeecorpus epididymis1.00infobox
NEDD9Bgeecaput epididymis1.00infobox
NEDD9Bgeecumulus cell1.00infobox
NEDD9Bgeeleft lung lobe1.00infobox
NEDD9BgeeGonadal ridge1.00infobox
NEDD9Bgeegranulocyte1.00infobox
NEDD9Bgeeright lung lobe1.00infobox
NEDD9Bgeedecidua1.00infobox
NEDD9Bgeegastrula1.00infobox
NEDD9Bgeeleft colon1.00infobox
NEDD9Bgeemolar1.00infobox
NEDD9Bgeeciliary body1.00infobox
NEDD9BioGPSMore reference expression data1.00infobox
NEDD9Chr.Chromosome 6 (human)1.00infobox
NEDD9Chr.Chromosome 13 (mouse)1.00infobox
NEDD9DatabasesNCBI: entry; OMA: entry1.00infobox
NEDD9End11,382,348 bp1.00infobox
NEDD9End41,640,838 bp1.00infobox

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