Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

KRAS

KRAS (Kirsten rat sarcoma virus oncogene homologue) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate).…

Art, Clinical significance when mutated & As a therapeutic target

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around KRAS. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.5.2
Aliases
KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene, GTPase, c-Ki-ras2, OES, c-Ki-ras, K-Ras 2, 'C-K-…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WA7, 1D8D, 1D8E, 3GFT, 4DSN, 4DSO, 4EPR, 4EPT, 4EPV, 4EPW, 4EPX, 4EPY, 4L8G, 4LDJ, 4LPK, 4LRW, 4LUC, 4LV6,…
Band
12p12.1 · 6 G3|6 77.37 cM
Bgee
trigeminal ganglion · pylorus · nipple · oral cavity · mucosa of sigmoid colon
BioGPS
More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance when mutated

KRAS testing

As a therapeutic target

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

KRAS

Nodes124
Edges123
Triples248
Avg. degree1.98
Density0.016129
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

KRAS

Top relations

Gene ontology · 52
KRAS → actin cytoskeleton organization, axon guidance, cytokine-mediated signaling pathway, cytoplasm, cytosol, endocrine signaling, epidermal growth factor receptor signaling pathway, epithelial tube branching involved in lung morphogenesis, ERBB2 signaling pathway, extrinsic component of cytoplasmic side of plasma membrane, Fc-epsilon receptor signaling pathway, female pregnancy, focal adhesion, forebrain astrocyte development, GDP binding, GMP binding, GTP binding, GTPase activity, homeostasis of number of cells within a tissue, identical protein binding
related to Function · 23
KRAS → GAP, GDP, GEF, GLUT1, GTP, GTPase-activating, Guanine Nucleotide Exchange Factor, HRAS, In, It, NRAS, Once, Other, PI, Raf, Ras, RasGAP, SOS1, Subsequently, The
Bgee · 20
KRAS → cardia, conjunctival fornix, cumulus cell, endothelial cell, endothelial cell of lymphatic vessel, hair follicle, jejunal mucosa, left colon, left lung lobe, medial ganglionic eminence, medullary collecting duct, mucosa of pharynx, mucosa of sigmoid colon, nipple, oral cavity, Paneth cell, pylorus, tail of epididymis, trigeminal ganglion, ureter
RNA expression pattern · 20
KRAS → cardia, conjunctival fornix, cumulus cell, endothelial cell, endothelial cell of lymphatic vessel, hair follicle, jejunal mucosa, left colon, left lung lobe, medial ganglionic eminence, medullary collecting duct, mucosa of pharynx, mucosa of sigmoid colon, nipple, oral cavity, Paneth cell, pylorus, tail of epididymis, trigeminal ganglion, ureter
related to G12D mutation · 17
KRAS → As, ASP3082, AZD0022, But, G12D, Her, HLA, In, In June, INCB161734, KRAS G12D, LY3962673, National Cancer Institute, October, PROTAC, The, Whipple Surgery
related to External links · 14
KRAS → Cardiofaciocutaneous SyndromeGeneReviews/NCBI/NIH/UW, Human GTPase KRas, KRAS Reference ControlsGeneReviews/NCBI/NIH/UW, KRAS Reference Standards, Learn, Medicine Medical Subject Headings, MeSH, National Library, Noonan, Overview, P01116, PDB, PDBe-KB, UniProt
related to KRAS testing · 12
KRAS → Drug Administration, EGFR, Erbitux, FDA, If, In, In July, QIAGEN, The, This, US Food, Vectibix
related to Lung cancer · 12
KRAS → Different, EGFR, However, Iressa, KRAS-mutant, Lung, No, NSCLC, Patients, Tarceva, The, Whether
related to As a therapeutic target · 11
KRAS → Achilles, California, Currently, Howard Hughes Medical Institute, However, Hyperactivating KRAS, Kevan, KRAS-G12C, KRAS-targeting, Shokat, University
related to Pan-KRAS (WT or any mutation) · 11
KRAS → AMG410, An, As, ASO, AstraZeneca/Ionis Therapeutics, AZD4785, Development, July, KO-2806, LUNA18, October

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer protein gene mutation colorectal k-ras lung gtp gdp cell mutations human patients clinical inhibitor treatment bp gtpase cells ras

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
KRAS3.6.5.21.00infobox
KRASAliasesKRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene, GTPase, c-Ki-ras2, OES, c-Ki-ras, K-Ras 2, 'C-K-…1.00infobox
KRASAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WA7, 1D8D, 1D8E, 3GFT, 4DSN, 4DSO, 4EPR, 4EPT, 4EPV, 4EPW, 4EPX, 4EPY, 4L8G, 4LDJ, 4LPK, 4LRW, 4LUC, 4LV6,…1.00infobox
KRASBand12p12.11.00infobox
KRASBand6 G3|6 77.37 cM1.00infobox
KRASBgeetrigeminal ganglion1.00infobox
KRASBgeepylorus1.00infobox
KRASBgeenipple1.00infobox
KRASBgeeoral cavity1.00infobox
KRASBgeemucosa of sigmoid colon1.00infobox
KRASBgeemucosa of pharynx1.00infobox
KRASBgeecardia1.00infobox
KRASBgeejejunal mucosa1.00infobox
KRASBgeetail of epididymis1.00infobox
KRASBgeeendothelial cell1.00infobox
KRASBgeePaneth cell1.00infobox
KRASBgeeleft colon1.00infobox
KRASBgeemedullary collecting duct1.00infobox
KRASBgeeconjunctival fornix1.00infobox
KRASBgeehair follicle1.00infobox
KRASBgeeureter1.00infobox
KRASBgeecumulus cell1.00infobox
KRASBgeeendothelial cell of lymphatic vessel1.00infobox
KRASBgeeleft lung lobe1.00infobox
KRASBgeemedial ganglionic eminence1.00infobox
KRASBioGPSMore reference expression data1.00infobox
KRASChr.Chromosome 12 (human)1.00infobox
KRASChr.Chromosome 6 (mouse)1.00infobox
KRASDatabasesNCBI: entry; OMA: entry1.00infobox
KRASEnd25,250,936 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.