KRAS

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KRAS topic overview

The analysis highlights Art, Clinical significance when mutated and As a therapeutic target as prominent areas in the source structure around KRAS.

Related topics: 117
Source areas: 6
Connected nodes: 123
Extracted relationships: 248
Concept neighborhoods: 39
Bridge connections: 123

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

As a therapeutic target · 40 topics

Overview · 28 topics

Clinical significance when mutated · 26 topics

Function · 16 topics

Interactions · 5 topics

KRAS testing · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.5.2: ↗
Aliases: KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene, GTPase, c-Ki-ras2, OES, c-Ki-ras, K-Ras 2, 'C-K-…
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WA7, 1D8D, 1D8E, 3GFT, 4DSN, 4DSO, 4EPR, 4EPT, 4EPV, 4EPW, 4EPX, 4EPY, 4L8G, 4LDJ, 4LPK, 4LRW, 4LUC, 4LV6,…
Band: 12p12.1 · 6 G3|6 77.37 cM
Bgee: trigeminal ganglion · pylorus · nipple · oral cavity · mucosa of sigmoid colon
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

KRAS testing

As a therapeutic target

Kevan M. Shokat
Howard Hughes Medical Institute
University of California
Antisense oligonucleotide Antisense therapy
AZD4785 AZD4785?action=edit&redlink=1
AstraZeneca
Ionis Therapeutics Ionis Therapeutics?action=edit&redlink=1
Knockdown Gene knockdown
Paluratide Paluratide?action=edit&redlink=1
Daraxonrasib
Darlifarnib
Farnesyl transferase inhibitor
AMG410 AMG410?action=edit&redlink=1
Electrophilic
Covalent bonds Covalent bond
Nucleophilic
Covalent inhibitor Targeted covalent inhibitors
Amgen
Non-small cell lung cancer
Adagrasib
Mirati Therapeutics
Wellspring Biosciences Wellspring Biosciences?action=edit&redlink=1
Janssen Janssen Biotech
Investigational new drug
Divarasib
Elironrasib
REVOLUTION Medicines REVOLUTION Medicines?action=edit&redlink=1
Solid tumors
Calderasib
Breakthrough therapy
Food and Drug Administration
Elisrasib
Garsorasib
Fulzerasib
Zoldonrasib
PROTAC
Setidegrasib
National Cancer Institute
Whipple Surgery
Engineered T cells CAR T cell

Interactions

Interact Protein-protein interaction
PIK3CG
RALGDS
RASSF2
Calmodulin

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How KRAS connects Entity context

The extracted context around KRAS shows recurring relationship patterns in the source. For example, KRAS → actin cytoskeleton organization, axon guidance, cytokine-mediated signaling pathway, cytoplasm, cytosol, endocrine signaling, epidermal growth factor receptor signaling pathway, epithelial tube branching involved in lung morphogenesis, ERBB2 signaling pathway, extrinsic component of cytoplasmic side of plasma membrane, Fc-epsilon receptor signaling pathway, female pregnancy, focal adhesion, forebrain astrocyte development, GDP binding, GMP binding, GTP binding, GTPase activity, homeostasis of number of cells within a tissue, identical protein binding Another extracted example is KRAS → GAP, GDP, GEF, GLUT1, GTP, GTPase-activating, Guanine Nucleotide Exchange Factor, HRAS, In, It, NRAS, Once, Other, PI, Raf, Ras, RasGAP, SOS1, Subsequently, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 52

KRAS → actin cytoskeleton organization, axon guidance, cytokine-mediated signaling pathway, cytoplasm, cytosol, endocrine signaling, epidermal growth factor receptor signaling pathway, epithelial tube branching involved in lung morphogenesis, ERBB2 signaling pathway, extrinsic component of cytoplasmic side of plasma membrane, Fc-epsilon receptor signaling pathway, female pregnancy, focal adhesion, forebrain astrocyte development, GDP binding, GMP binding, GTP binding, GTPase activity, homeostasis of number of cells within a tissue, identical protein binding

related to Function · 23

KRAS → GAP, GDP, GEF, GLUT1, GTP, GTPase-activating, Guanine Nucleotide Exchange Factor, HRAS, In, It, NRAS, Once, Other, PI, Raf, Ras, RasGAP, SOS1, Subsequently, The

Bgee · 20

KRAS → cardia, conjunctival fornix, cumulus cell, endothelial cell, endothelial cell of lymphatic vessel, hair follicle, jejunal mucosa, left colon, left lung lobe, medial ganglionic eminence, medullary collecting duct, mucosa of pharynx, mucosa of sigmoid colon, nipple, oral cavity, Paneth cell, pylorus, tail of epididymis, trigeminal ganglion, ureter

RNA expression pattern · 20

related to G12D mutation · 17

KRAS → As, ASP3082, AZD0022, But, G12D, Her, HLA, In, In June, INCB161734, KRAS G12D, LY3962673, National Cancer Institute, October, PROTAC, The, Whipple Surgery

related to External links · 14

KRAS → Cardiofaciocutaneous SyndromeGeneReviews/NCBI/NIH/UW, Human GTPase KRas, KRAS Reference ControlsGeneReviews/NCBI/NIH/UW, KRAS Reference Standards, Learn, Medicine Medical Subject Headings, MeSH, National Library, Noonan, Overview, P01116, PDB, PDBe-KB, UniProt

related to KRAS testing · 12

KRAS → Drug Administration, EGFR, Erbitux, FDA, If, In, In July, QIAGEN, The, This, US Food, Vectibix

related to Lung cancer · 12

KRAS → Different, EGFR, However, Iressa, KRAS-mutant, Lung, No, NSCLC, Patients, Tarceva, The, Whether

related to As a therapeutic target · 11

KRAS → Achilles, California, Currently, Howard Hughes Medical Institute, However, Hyperactivating KRAS, Kevan, KRAS-G12C, KRAS-targeting, Shokat, University

related to Pan-KRAS (WT or any mutation) · 11

KRAS → AMG410, An, As, ASO, AstraZeneca/Ionis Therapeutics, AZD4785, Development, July, KO-2806, LUNA18, October

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer protein gene mutation colorectal k-ras lung gtp gdp cell mutations human patients clinical inhibitor treatment bp gtpase cells ras

KRAS relationships Subject–Predicate–Object triples

TTTA extracted 248 structured relationships around KRAS. Examples in this analysis include KRAS → 3.6.5.2 → ↗ and KRAS → Aliases → KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene, GTPase, c-Ki-ras2, OES, c-Ki-ras, K-Ras 2, 'C-K-…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
KRAS	3.6.5.2	↗	1.00	infobox
KRAS	Aliases	KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene, GTPase, c-Ki-ras2, OES, c-Ki-ras, K-Ras 2, 'C-K-…	1.00	infobox
KRAS	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WA7, 1D8D, 1D8E, 3GFT, 4DSN, 4DSO, 4EPR, 4EPT, 4EPV, 4EPW, 4EPX, 4EPY, 4L8G, 4LDJ, 4LPK, 4LRW, 4LUC, 4LV6,…	1.00	infobox
KRAS	Band	12p12.1	1.00	infobox
KRAS	Band	6 G3\|6 77.37 cM	1.00	infobox
KRAS	Bgee	trigeminal ganglion	1.00	infobox
KRAS	Bgee	pylorus	1.00	infobox
KRAS	Bgee	nipple	1.00	infobox
KRAS	Bgee	oral cavity	1.00	infobox
KRAS	Bgee	mucosa of sigmoid colon	1.00	infobox
KRAS	Bgee	mucosa of pharynx	1.00	infobox
KRAS	Bgee	cardia	1.00	infobox
KRAS	Bgee	jejunal mucosa	1.00	infobox
KRAS	Bgee	tail of epididymis	1.00	infobox
KRAS	Bgee	endothelial cell	1.00	infobox
KRAS	Bgee	Paneth cell	1.00	infobox
KRAS	Bgee	left colon	1.00	infobox
KRAS	Bgee	medullary collecting duct	1.00	infobox
KRAS	Bgee	conjunctival fornix	1.00	infobox
KRAS	Bgee	hair follicle	1.00	infobox
KRAS	Bgee	ureter	1.00	infobox
KRAS	Bgee	cumulus cell	1.00	infobox
KRAS	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
KRAS	Bgee	left lung lobe	1.00	infobox
KRAS	Bgee	medial ganglionic eminence	1.00	infobox
KRAS	BioGPS	More reference expression data	1.00	infobox
KRAS	Chr.	Chromosome 12 (human)	1.00	infobox
KRAS	Chr.	Chromosome 6 (mouse)	1.00	infobox
KRAS	Databases	NCBI: entry; OMA: entry	1.00	infobox
KRAS	End	25,250,936 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around KRAS bring nearby vocabulary together. In this analysis, examples include Cancer, Mutations and Colorectal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

KRAS
- Cancer
- Mutations
- Colorectal
- Gene
- Lung
- Mutation
- Patients
- Tumors
- Treatment
- Cancers
- Cells
- Human
kras
- Cancer
- Mutations
- Colorectal
- Gene
- Lung
- Mutation
- Patients
- Tumors
- Treatment
- Cancers
- Cells
- Human
gene product
- Kras
- Patients
- Protein
- Kirsten
- Bp
- Chr
- Gtpase
- Ras
- Also
- Cells
- Colorectal
- Human
cell signaling
- Lung
- Signals
- Protein
- Cancer
- Inhibitor
- Treatment
- Kras
- Mutations
- Gene
- Band
- Bp
- Chr
colorectal cancer
- Colorectal
- Mutations
- Kras
- Lung
- Treatment
- Cancers
- Mutation
- Cells
- Cetuximab
- Patients
- Pancreatic
- Gene
pancreatic cancer
- Colorectal
- Kras
- Lung
- Treatment
- Mutations
- Mutation
- Cells
- Tumors
- Patients
- Pancreatic
- Gene
- Cell
cell growth
- Lung
- Signals
- Protein
- Cancer
- Inhibitor
- Treatment
- Kras
- Mutations
- Gene
- Band
- Bp
- Chr
cancer research
- Colorectal
- Kras
- Lung
- Treatment
- Mutations
- Mutation
- Cells
- Patients
- Pancreatic
- Gene
- Cell
- G12d

Connections between topic areas Semantic bridges

For KRAS, one of the stronger structural bridges in this analysis connects KRAS with As a therapeutic target. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

KRAS — As a therapeutic target · splits 83 ⟂ 41

KRAS — Overview · splits 95 ⟂ 29

KRAS — Clinical significance when mutated · splits 97 ⟂ 27

KRAS — Function · splits 107 ⟂ 17

KRAS — Interactions · splits 118 ⟂ 6

KRAS — KRAS testing · splits 121 ⟂ 3

Map overview Semantic statistics

KRAS

Nodes124

Edges123

Triples248

Avg. degree1.98

Density0.016129

Components1

Source & methodology

TTTA analyzes the structure around KRAS to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance when mutated & As a therapeutic target, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — KRAS · EN edition · Analysis: TopicsToTalkAbout