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NCK1: Interactions, Function & Gene

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Language: English [EN]
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NCK1 topic overview

The analysis highlights Interactions, Function and Gene as prominent areas in the source structure around NCK1.

Related topics
38
Source areas
4
Connected nodes
42
Extracted relationships
164
Concept neighborhoods
9
Bridge connections
42

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 28 topics
Function · 5 topics
Gene · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CI8, 2CI9, 2JS0, 2JS2, 2JW4
Band
3q22.3 · 9|9 E3.3
Bgee
human penis · Achilles tendon · oral cavity · epithelium of nasopharynx · decidua
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NCK1 connects Entity context

The extracted context around NCK1 shows recurring relationship patterns in the source. For example, NCK1 → actin filament organization, cadherin binding, cell migration, cell-cell junction, cytoplasm, cytoskeletal anchor activity, cytosol, endoplasmic reticulum, ephrin receptor binding, ephrin receptor signaling pathway, eukaryotic initiation factor eIF2 binding, Fc-gamma receptor signaling pathway involved in phagocytosis, lamellipodium assembly, molecular adaptor activity, negative regulation of cell death, negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-serine phosphorylation, negative regulation of PERK-mediated unfolded protein response, negative regulation of protein kinase activity Another extracted example is NCK1 → ABL1, CBL, DAG1, DNM1, EGFR, EIF2B2, EPHB1, KHDRBS1, LCP2, MAP4K1, MAP4K4, MINK1, NCKIPSD, NEDD9, PAK1, PDGFRB, PKN2, PTK2, RASA1, RICS. Use these groups to spot repeated connection types before inspecting the individual relationships.

NCK1

Top relations

Gene ontology · 50
NCK1 → actin filament organization, cadherin binding, cell migration, cell-cell junction, cytoplasm, cytoskeletal anchor activity, cytosol, endoplasmic reticulum, ephrin receptor binding, ephrin receptor signaling pathway, eukaryotic initiation factor eIF2 binding, Fc-gamma receptor signaling pathway involved in phagocytosis, lamellipodium assembly, molecular adaptor activity, negative regulation of cell death, negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-serine phosphorylation, negative regulation of PERK-mediated unfolded protein response, negative regulation of protein kinase activity
related to Interactions · 26
NCK1 → ABL1, CBL, DAG1, DNM1, EGFR, EIF2B2, EPHB1, KHDRBS1, LCP2, MAP4K1, MAP4K4, MINK1, NCKIPSD, NEDD9, PAK1, PDGFRB, PKN2, PTK2, RASA1, RICS
Bgee · 20
NCK1 → Achilles tendon, atrioventricular valve, decidua, epithelium of nasopharynx, esophagus, granulocyte, gums, human penis, intercostal muscle, masseter muscle, muscle of thigh, oral cavity, palpebral conjunctiva, saccule, skin of thigh, spermatocyte, tail of embryo, tonsil, uterus, vagina
RNA expression pattern · 20
NCK1 → Achilles tendon, atrioventricular valve, decidua, epithelium of nasopharynx, esophagus, granulocyte, gums, human penis, intercostal muscle, masseter muscle, muscle of thigh, oral cavity, palpebral conjunctiva, saccule, skin of thigh, spermatocyte, tail of embryo, tonsil, uterus, vagina
related to Function · 14
NCK1 → ER, IRE1alpha, IRS-1, It, JNK, PKB, RAS, SH2, SH3, Src, The, These, This, UPR
related to External links · 6
NCK1 → Cell Migration Gateway Archived, December, July, Nck1 Archived, Wayback Machine, Wayback Machine Info
Band · 2
NCK1 → 3q22.3, 9|9 E3.3
Chr. · 2
NCK1 → Chromosome 3 (human), Chromosome 9 (mouse)
End · 2
NCK1 → 100,428,187 bp, 136,951,606 bp
Aliases · 1
NCK1 → NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene human bp pathway stress chr band within chromosome signaling involved adaptor expression tyrosine cell also mouse nck receptor

NCK1 relationships Subject–Predicate–Object triples

TTTA extracted 164 structured relationships around NCK1. Examples in this analysis include NCK1 → Aliases → NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1 and NCK1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CI8, 2CI9, 2JS0, 2JS2, 2JW4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NCK1AliasesNCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 11.00infobox
NCK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CI8, 2CI9, 2JS0, 2JS2, 2JW41.00infobox
NCK1Band3q22.31.00infobox
NCK1Band9|9 E3.31.00infobox
NCK1Bgeehuman penis1.00infobox
NCK1BgeeAchilles tendon1.00infobox
NCK1Bgeeoral cavity1.00infobox
NCK1Bgeeepithelium of nasopharynx1.00infobox
NCK1Bgeedecidua1.00infobox
NCK1Bgeepalpebral conjunctiva1.00infobox
NCK1Bgeetonsil1.00infobox
NCK1Bgeevagina1.00infobox
NCK1Bgeegums1.00infobox
NCK1Bgeeskin of thigh1.00infobox
NCK1Bgeegranulocyte1.00infobox
NCK1Bgeeatrioventricular valve1.00infobox
NCK1Bgeetail of embryo1.00infobox
NCK1Bgeeesophagus1.00infobox
NCK1Bgeespermatocyte1.00infobox
NCK1Bgeemasseter muscle1.00infobox
NCK1Bgeeintercostal muscle1.00infobox
NCK1Bgeeuterus1.00infobox
NCK1Bgeesaccule1.00infobox
NCK1Bgeemuscle of thigh1.00infobox
NCK1BioGPSMore reference expression data1.00infobox
NCK1Chr.Chromosome 3 (human)1.00infobox
NCK1Chr.Chromosome 9 (mouse)1.00infobox
NCK1DatabasesNCBI: entry; OMA: entry1.00infobox
NCK1End136,951,606 bp1.00infobox
NCK1End100,428,187 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NCK1 bring nearby vocabulary together. In this analysis, examples include Protein, Stress and Actin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NCK1
    • Protein
    • Stress
    • Actin
    • Complex
    • Kinase
    • Migration
    • Adaptor
    • Mice
    • Receptor
    • Signal
    • Tyrosine
    • Cell
  • nck1
    • Protein
    • Stress
    • Actin
    • Complex
    • Kinase
    • Migration
    • Adaptor
    • Mice
    • Receptor
    • Signal
    • Tyrosine
    • Cell
  • gene
    • Human
    • Chromosome
    • Location
    • Nck
    • Bp
    • Chr
    • Protein
    • Function
    • Mouse
    • Nck-1
    • Sh3
    • Adaptor
  • chromosome 3
    • Bp
    • Human
    • Location
    • Band
    • Gene
    • Function
    • Mouse
    • Nck-1
    • Nck
    • External
    • Actin
    • Complex
  • unfolded protein response
    • Response
    • Unfolded
    • Insulin
    • Signaling
    • Phosphorylation
    • Pathway
    • Receptor
    • Signal
    • Tyrosine
    • Cell
    • Expression
    • Protein
  • function
    • Location
    • Adaptor
    • External
    • Nck
    • Bp
    • Chr
    • Chromosome
    • Actin
    • Complex
    • Gene
    • Human
    • Kinase
  • protein
    • Signaling
    • Receptor
    • Signal
    • Tyrosine
    • Response
    • Unfolded
    • Stress
    • Pathway
    • Sh3
    • Phosphorylation
    • Within
    • Bone
  • receptor tyrosine kinases
    • Signal
    • Tyrosine
    • Response
    • Sh3
    • Unfolded
    • Signaling
    • Stress
    • Within

Connections between topic areas Semantic bridges

For NCK1, one of the stronger structural bridges in this analysis connects NCK1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NCK1Interactions · splits 14 ⟂ 29
NCK1Function · splits 37 ⟂ 6
NCK1Gene · splits 39 ⟂ 4
NCK1Overview · splits 40 ⟂ 3

Map overview Semantic statistics

NCK1

Nodes43
Edges42
Triples164
Avg. degree1.95
Density0.046512
Components1

Source & methodology

TTTA analyzes the structure around NCK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NCK1 · EN edition · Analysis: TopicsToTalkAbout

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