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Dapsone

Dapsone, also known as 4,4'-sulfonyldianiline (SDA) or diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line medication for the treatment and prevention of pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D10AX05 (WHO) J04BA02 (WHO)
Bioavailability
70 to 80%
CAS Number
80-08-0 Y
ChEBI
CHEBI:4325 Y

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Overview

Medical uses

Contraindications and precautions

Adverse effects

Mechanism of action

History

Other uses

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Map overview Semantic statistics

Dapsone

Nodes101
Edges100
Triples120
Avg. degree1.98
Density0.019802
Components1

How this topic connects Entity context

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Dapsone

Top relations

related to Proposed use in antimalarial drugs · 16
Dapsone → Africa, African, Artemisinin, Chlorproguanil, February, G6PD, GlaxoSmithKline, However, It, Lapdap, October, Plasmodium, Saharan Africa, The, This, United Kingdom
related to Discovery · 12
Dapsone → Daniel Bovet, Ernest Fourneau, France, Further, Gerhard Domagk, German, Gladwin Buttle, In, Nobel Prize, Pasteur Institute, Paul Ehrlich, United Kingdom
related to Blood · 10
Dapsone → Abnormalities, Agranulocytosis, CO-oximeters, Hemolysis, It, Lapdap, Methemoglobinemia, Only, The, When
related to Mechanism of action · 10
Dapsone → Alzheimer's, As, Dihydropteroate, Function, H2O2-halide-mediated, HOCl, Myeloperoxidase, Sulfonamide, This, Though
related to Liver · 9
Dapsone → CYP2B6, CYP2C19, CYP2D6, CYP3A4, Cytochrome P450, P450, SCARs-see, These, Toxic
related to Dapsone gel · 8
Dapsone → Aczone, FDA, For, G6PD, In, In February, QLT USA, This
related to Autoimmune disease · 5
Dapsone → Chronic, Cutaneous, Idiopathic, Relapsing, There
related to External links · 5
Dapsone → Archived, Drug Information Portal, January, Medicine, National Library
has effect · 4
Dapsone → DRESS, Hypersensitivity, It, SCARs
Legal status · 3
Dapsone → AU: S4 (Prescription only), In general: ℞ (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

used effects also use effective may treatment combination side include methemoglobinemia leprosy drug hypersensitivity skin severe sulfone anemia mouth liver

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dapsone3D model (JSmol)Interactive image1.00infobox
DapsoneAHFS/Drugs.comMonograph1.00infobox
DapsoneATC codeD10AX05 (WHO) J04BA02 (WHO)1.00infobox
DapsoneBioavailability70 to 80%1.00infobox
DapsoneCAS Number80-08-0 Y1.00infobox
DapsoneChEBICHEBI:4325 Y1.00infobox
DapsoneChEMBLChEMBL1043 Y1.00infobox
DapsoneChemSpider2849 Y1.00infobox
DapsoneCompTox Dashboard (EPA)DTXSID40203711.00infobox
DapsoneDrugBankDB00250 Y1.00infobox
DapsoneECHA InfoCard100.001.1361.00infobox
DapsoneElimination half-life20 to 30 hours1.00infobox
DapsoneExcretionKidney1.00infobox
DapsoneFormulaC12H12N2O2S1.00infobox
DapsoneKEGGD00592 Y1.00infobox
DapsoneLegal statusAU: S4 (Prescription only)1.00infobox
DapsoneLegal statusUS: ℞-only1.00infobox
DapsoneLegal statusIn general: ℞ (Prescription only)1.00infobox
DapsoneLicense dataUS DailyMed: Dapsone1.00infobox
DapsoneMedlinePlusa6821281.00infobox
DapsoneMelting point175 to 176 °C (347 to 349 °F)1.00infobox
DapsoneMetabolismLiver (mostly CYP2E1-mediated)1.00infobox
DapsoneMolar mass248.30 g·mol−11.00infobox
DapsoneProtein binding70 to 90%1.00infobox
DapsonePubChem CID29551.00infobox
DapsoneRoutes of administrationBy mouth, topical1.00infobox
DapsoneTrade namesAczone, others1.00infobox
DapsoneUNII8W5C5183021.00infobox
Dapsonecauseshemolytic anemia in patients with G6PD deficiency0.90text
Dapsoneis arecommended treatment for erythema elevatum diutinum0.90text

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