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Dapsone: History & Applications

Dapsone, also known as 4,4'-sulfonyldianiline (SDA) or diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line medication for the treatment and prevention of pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune…

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Dapsone topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Dapsone.

Related topics
93
Source areas
7
Connected nodes
100
Extracted relationships
120
Concept neighborhoods
25
Bridge connections
100

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 26 topics
History · 20 topics
Overview · 17 topics
Mechanism of action · 12 topics
Medical uses · 10 topics
Contraindications and precautions · 4 topics
Other uses · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D10AX05 (WHO) J04BA02 (WHO)
Bioavailability
70 to 80%
CAS Number
80-08-0 Y
ChEBI
CHEBI:4325 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications and precautions

Adverse effects

Mechanism of action

History

Other uses

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dapsone connects Entity context

The extracted context around Dapsone shows recurring relationship patterns in the source. For example, Dapsone → Africa, African, Artemisinin, Chlorproguanil, February, G6PD, GlaxoSmithKline, However, It, Lapdap, October, Plasmodium, Saharan Africa, The, This, United Kingdom Another extracted example is Dapsone → Daniel Bovet, Ernest Fourneau, France, Further, Gerhard Domagk, German, Gladwin Buttle, In, Nobel Prize, Pasteur Institute, Paul Ehrlich, United Kingdom. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dapsone

Top relations

related to Proposed use in antimalarial drugs · 16
Dapsone → Africa, African, Artemisinin, Chlorproguanil, February, G6PD, GlaxoSmithKline, However, It, Lapdap, October, Plasmodium, Saharan Africa, The, This, United Kingdom
related to Discovery · 12
Dapsone → Daniel Bovet, Ernest Fourneau, France, Further, Gerhard Domagk, German, Gladwin Buttle, In, Nobel Prize, Pasteur Institute, Paul Ehrlich, United Kingdom
related to Blood · 10
Dapsone → Abnormalities, Agranulocytosis, CO-oximeters, Hemolysis, It, Lapdap, Methemoglobinemia, Only, The, When
related to Mechanism of action · 10
Dapsone → Alzheimer's, As, Dihydropteroate, Function, H2O2-halide-mediated, HOCl, Myeloperoxidase, Sulfonamide, This, Though
related to Liver · 9
Dapsone → CYP2B6, CYP2C19, CYP2D6, CYP3A4, Cytochrome P450, P450, SCARs-see, These, Toxic
related to Dapsone gel · 8
Dapsone → Aczone, FDA, For, G6PD, In, In February, QLT USA, This
related to Autoimmune disease · 5
Dapsone → Chronic, Cutaneous, Idiopathic, Relapsing, There
related to External links · 5
Dapsone → Archived, Drug Information Portal, January, Medicine, National Library
has effect · 4
Dapsone → DRESS, Hypersensitivity, It, SCARs
Legal status · 3
Dapsone → AU: S4 (Prescription only), In general: ℞ (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

used effects also use effective may treatment combination side include methemoglobinemia leprosy drug hypersensitivity skin severe sulfone anemia mouth liver

Dapsone relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around Dapsone. Examples in this analysis include Dapsone → 3D model (JSmol) → Interactive image and Dapsone → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dapsone3D model (JSmol)Interactive image1.00infobox
DapsoneAHFS/Drugs.comMonograph1.00infobox
DapsoneATC codeD10AX05 (WHO) J04BA02 (WHO)1.00infobox
DapsoneBioavailability70 to 80%1.00infobox
DapsoneCAS Number80-08-0 Y1.00infobox
DapsoneChEBICHEBI:4325 Y1.00infobox
DapsoneChEMBLChEMBL1043 Y1.00infobox
DapsoneChemSpider2849 Y1.00infobox
DapsoneCompTox Dashboard (EPA)DTXSID40203711.00infobox
DapsoneDrugBankDB00250 Y1.00infobox
DapsoneECHA InfoCard100.001.1361.00infobox
DapsoneElimination half-life20 to 30 hours1.00infobox
DapsoneExcretionKidney1.00infobox
DapsoneFormulaC12H12N2O2S1.00infobox
DapsoneKEGGD00592 Y1.00infobox
DapsoneLegal statusAU: S4 (Prescription only)1.00infobox
DapsoneLegal statusUS: ℞-only1.00infobox
DapsoneLegal statusIn general: ℞ (Prescription only)1.00infobox
DapsoneLicense dataUS DailyMed: Dapsone1.00infobox
DapsoneMedlinePlusa6821281.00infobox
DapsoneMelting point175 to 176 °C (347 to 349 °F)1.00infobox
DapsoneMetabolismLiver (mostly CYP2E1-mediated)1.00infobox
DapsoneMolar mass248.30 g·mol−11.00infobox
DapsoneProtein binding70 to 90%1.00infobox
DapsonePubChem CID29551.00infobox
DapsoneRoutes of administrationBy mouth, topical1.00infobox
DapsoneTrade namesAczone, others1.00infobox
DapsoneUNII8W5C5183021.00infobox
Dapsonecauseshemolytic anemia in patients with G6PD deficiency0.90text
Dapsoneis arecommended treatment for erythema elevatum diutinum0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dapsone bring nearby vocabulary together. In this analysis, examples include Effective, Used and Treatment. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dapsone
    • Effective
    • Used
    • Treatment
    • Combination
    • Acne
    • Anemia
    • Cause
    • Drug
    • Effects
    • Disease
    • Drugs
    • First
  • dapsone
    • Effective
    • Used
    • Treatment
    • Combination
    • Acne
    • Anemia
    • Cause
    • Drug
    • Effects
    • Disease
    • Drugs
    • First
  • decrease in blood cells
    • Hypersensitivity
    • May
    • Effects
    • Liver
    • Adverse
    • Antimalarial
    • Disease
    • Drugs
    • Leprosy
    • Mouth
    • Syndrome
    • Anemia
  • red blood cell breakdown
    • Hypersensitivity
    • May
    • Effects
    • Liver
    • Adverse
    • Antimalarial
    • Disease
    • Drugs
    • Leprosy
    • Mouth
    • Syndrome
    • Anemia
  • severe cutaneous adverse reactions
    • Liver
    • Disease
    • Syndrome
    • Effects
    • Deficiency
    • Side
    • Antimalarial
    • Blood
    • Common
    • Drugs
    • Effective
    • Leprosy
  • white blood cell
    • Hypersensitivity
    • May
    • Effects
    • Liver
    • Adverse
    • Antimalarial
    • Disease
    • Drugs
    • Leprosy
    • Mouth
    • Syndrome
    • Anemia
  • blood gas analysis
    • Hypersensitivity
    • May
    • Effects
    • Liver
    • Adverse
    • Antimalarial
    • Disease
    • Drugs
    • Leprosy
    • Mouth
    • Syndrome
    • Anemia
  • adverse effects
    • Side
    • Liver
    • Disease
    • Include
    • Syndrome
    • Adverse
    • Effects
    • Blood
    • Common
    • Deficiency
    • Hypersensitivity
    • Skin

Connections between topic areas Semantic bridges

For Dapsone, one of the stronger structural bridges in this analysis connects Dapsone with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dapsone — Adverse effects · splits 74 ⟂ 27
Dapsone — History · splits 80 ⟂ 21
Dapsone — Overview · splits 83 ⟂ 18
Dapsone — Mechanism of action · splits 88 ⟂ 13
Dapsone — Medical uses · splits 90 ⟂ 11
Dapsone — Contraindications and precautions · splits 96 ⟂ 5
Dapsone — Other uses · splits 96 ⟂ 5

Map overview Semantic statistics

Dapsone

Nodes101
Edges100
Triples120
Avg. degree1.98
Density0.019802
Components1

Source & methodology

TTTA analyzes the structure around Dapsone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dapsone · EN edition · Analysis: TopicsToTalkAbout

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