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Allopurinol: History, Community, Culture & Applications

Allopurinol is a medication used to decrease high blood uric acid levels. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. It is taken orally (by mouth) or intravenously (injected into a vein).

Language: English [EN]
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Allopurinol topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Allopurinol.

Related topics
88
Source areas
7
Connected nodes
95
Extracted relationships
122
Concept neighborhoods
32
Bridge connections
95

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Drug interactions · 21 topics
Medical uses · 18 topics
Pharmacology · 16 topics
Overview · 13 topics
Side effects · 12 topics
History · 7 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AA01 (WHO)
Bioavailability
78±20%
CAS Number
315-30-0 Y
ChEBI
CHEBI:40279 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Drug interactions

Pharmacology

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Allopurinol connects Entity context

The extracted context around Allopurinol shows recurring relationship patterns in the source. For example, Allopurinol → American College, As, Consortium, CPIC, European, FDA, FDA-approved, Han Chinese, HLA-B, However, Japanese, Koreans, Rheumatology, SJS, Stevens-Johnson, TEN, Thai, The, The Clinical Pharmacogenetics Implementation, The HLA-B Another extracted example is Allopurinol → Allopurinol Therapy, Biotechnology Information, Dean, Dean LC, Genotype, HLA-B, In Pratt VM, Kattman BL, March, McLeod HL, Medical Genetics Summaries, National Center, NCBI, PMID, Rubinstein WS, Scott SA. Use these groups to spot repeated connection types before inspecting the individual relationships.

Allopurinol

Top relations

related to Pharmacogenetics · 20
Allopurinol → American College, As, Consortium, CPIC, European, FDA, FDA-approved, Han Chinese, HLA-B, However, Japanese, Koreans, Rheumatology, SJS, Stevens-Johnson, TEN, Thai, The, The Clinical Pharmacogenetics Implementation, The HLA-B
related to Further reading · 16
Allopurinol → Allopurinol Therapy, Biotechnology Information, Dean, Dean LC, Genotype, HLA-B, In Pratt VM, Kattman BL, March, McLeod HL, Medical Genetics Summaries, National Center, NCBI, PMID, Rubinstein WS, Scott SA
related to Brands · 13
Allopurinol → Allohexal, Alloril, Allosig, Aluron, August, Burroughs Wellcome, FDA, Milurit, Progout, United States, Zyloprim, Zyloric, Zyrik
has effect · 9
Allopurinol → Because, DRESS, First, However, Johnson, More, Second, Stevens, The
related to Drug interactions · 6
Allopurinol → AUC, Azathioprine, Cmax, Didanosine, Drug, Giving
related to history · 6
Allopurinol → Gertrude Elion's, However, Robins, Roland, Wayne Rundles, Wellcome Research Laboratories
related to Mechanism of action · 5
Allopurinol → In, Increased, Purine-2, While, Xanthine
related to Gout · 4
Allopurinol → It, Lesch, Nyhan, The
Legal status · 3
Allopurinol → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Cardiovascular disease · 3
Allopurinol → However, Independently, There

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

used gout xanthine kidney uric acid drug also medication oxidase side effects use treatment hla-b levels syndrome disease purine 5801

Allopurinol relationships Subject–Predicate–Object triples

TTTA extracted 122 structured relationships around Allopurinol. Examples in this analysis include Allopurinol → 3D model (JSmol) → Interactive image and Allopurinol → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Allopurinol3D model (JSmol)Interactive image1.00infobox
AllopurinolAHFS/Drugs.comMonograph1.00infobox
AllopurinolATC codeM04AA01 (WHO)1.00infobox
AllopurinolBioavailability78±20%1.00infobox
AllopurinolCAS Number315-30-0 Y1.00infobox
AllopurinolChEBICHEBI:40279 Y1.00infobox
AllopurinolChEMBLChEMBL1467 Y1.00infobox
AllopurinolChemSpider2010 Y1.00infobox
AllopurinolCompTox Dashboard (EPA)DTXSID40225731.00infobox
AllopurinolDrugBankDB00437 Y1.00infobox
AllopurinolECHA InfoCard100.005.6841.00infobox
AllopurinolElimination half-life2 h (oxipurinol 18–30 h)1.00infobox
AllopurinolFormulaC5H4N4O1.00infobox
AllopurinolIUPHAR/BPS67951.00infobox
AllopurinolKEGGD00224 Y1.00infobox
AllopurinolLegal statusAU: S4 (Prescription only)1.00infobox
AllopurinolLegal statusUK: POM (Prescription only)1.00infobox
AllopurinolLegal statusUS: ℞-only1.00infobox
AllopurinolLicense dataUS DailyMed: Allopurinol1.00infobox
AllopurinolMedlinePlusa6826731.00infobox
AllopurinolMetabolismLiver (80% oxipurinol, 10% allopurinol ribosides)1.00infobox
AllopurinolMolar mass136.114 g·mol−11.00infobox
AllopurinolPregnancy categoryAU: B21.00infobox
AllopurinolProtein bindingNegligible1.00infobox
AllopurinolPubChem CID1354019071.00infobox
AllopurinolRoutes of administrationOral, intravenous1.00infobox
AllopurinolTrade namesZyloprim, Caplenal, Zyloric, others1.00infobox
AllopurinolUNII63CZ7GJN5I1.00infobox
Allopurinolis amedication used to decrease high blood uric acid levels0.90text
Allopurinolis ageneric drug sold under a variety of brand names0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Allopurinol bring nearby vocabulary together. In this analysis, examples include Also, Drug and Oxidase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Allopurinol
    • Also
    • Drug
    • Oxidase
    • Treatment
    • Used
    • Xanthine
    • Action
    • Drugs
    • However
    • Disease
    • Use
    • Gout
  • allopurinol
    • Also
    • Drug
    • Oxidase
    • Treatment
    • Used
    • Xanthine
    • Action
    • Drugs
    • However
    • Disease
    • Use
    • Gout
  • high blood uric acid levels
    • Uric
    • Levels
    • High
    • Used
    • Disease
    • Gout
    • Kidney
    • Oxidase
    • Xanthine
    • Also
    • Hypoxanthine
    • Include
  • uric acid
    • Uric
    • Levels
    • High
    • Oxidase
    • Xanthine
    • Also
    • Hypoxanthine
    • Purine
    • Used
    • Disease
    • Gout
    • Kidney
  • gout
    • High
    • Acute
    • Levels
    • Used
    • Disease
    • Syndrome
    • Kidney
    • Uric
    • Include
    • Medical
    • Action
    • Drugs
  • glycogen storage disease
    • Levels
    • Syndrome
    • Use
    • Used
    • Gout
    • Kidney
    • Uric
    • Drug
    • Include
    • Medical
    • Action
    • Drugs
  • inflammatory bowel disease
    • Levels
    • Syndrome
    • Use
    • Used
    • Gout
    • Kidney
    • Uric
    • Drug
    • Include
    • Medical
    • Action
    • Drugs
  • crohn's disease
    • Levels
    • Syndrome
    • Use
    • Used
    • Gout
    • Kidney
    • Uric
    • Drug
    • Include
    • Medical
    • Action
    • Drugs

Connections between topic areas Semantic bridges

For Allopurinol, one of the stronger structural bridges in this analysis connects Allopurinol with Drug interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AllopurinolDrug interactions · splits 74 ⟂ 22
AllopurinolMedical uses · splits 77 ⟂ 19
AllopurinolPharmacology · splits 79 ⟂ 17
AllopurinolOverview · splits 82 ⟂ 14
AllopurinolSide effects · splits 83 ⟂ 13
AllopurinolHistory · splits 88 ⟂ 8

Map overview Semantic statistics

Allopurinol

Nodes96
Edges95
Triples122
Avg. degree1.98
Density0.020833
Components1

Source & methodology

TTTA analyzes the structure around Allopurinol to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Allopurinol · EN edition · Analysis: TopicsToTalkAbout

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