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Allopurinol

Allopurinol is a medication used to decrease high blood uric acid levels. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. It is taken orally (by mouth) or intravenously (injected into a vein).

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AA01 (WHO)
Bioavailability
78±20%
CAS Number
315-30-0 Y
ChEBI
CHEBI:40279 Y

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Overview

Medical uses

Side effects

Drug interactions

Pharmacology

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Allopurinol

Nodes96
Edges95
Triples122
Avg. degree1.98
Density0.020833
Components1

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Allopurinol

Top relations

related to Pharmacogenetics · 20
Allopurinol → American College, As, Consortium, CPIC, European, FDA, FDA-approved, Han Chinese, HLA-B, However, Japanese, Koreans, Rheumatology, SJS, Stevens-Johnson, TEN, Thai, The, The Clinical Pharmacogenetics Implementation, The HLA-B
related to Further reading · 16
Allopurinol → Allopurinol Therapy, Biotechnology Information, Dean, Dean LC, Genotype, HLA-B, In Pratt VM, Kattman BL, March, McLeod HL, Medical Genetics Summaries, National Center, NCBI, PMID, Rubinstein WS, Scott SA
related to Brands · 13
Allopurinol → Allohexal, Alloril, Allosig, Aluron, August, Burroughs Wellcome, FDA, Milurit, Progout, United States, Zyloprim, Zyloric, Zyrik
has effect · 9
Allopurinol → Because, DRESS, First, However, Johnson, More, Second, Stevens, The
related to Drug interactions · 6
Allopurinol → AUC, Azathioprine, Cmax, Didanosine, Drug, Giving
related to history · 6
Allopurinol → Gertrude Elion's, However, Robins, Roland, Wayne Rundles, Wellcome Research Laboratories
related to Mechanism of action · 5
Allopurinol → In, Increased, Purine-2, While, Xanthine
related to Gout · 4
Allopurinol → It, Lesch, Nyhan, The
Legal status · 3
Allopurinol → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Cardiovascular disease · 3
Allopurinol → However, Independently, There

Important terminology Word statistics

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Important terminology

used gout xanthine kidney uric acid drug also medication oxidase side effects use treatment hla-b levels syndrome disease purine 5801

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Allopurinol3D model (JSmol)Interactive image1.00infobox
AllopurinolAHFS/Drugs.comMonograph1.00infobox
AllopurinolATC codeM04AA01 (WHO)1.00infobox
AllopurinolBioavailability78±20%1.00infobox
AllopurinolCAS Number315-30-0 Y1.00infobox
AllopurinolChEBICHEBI:40279 Y1.00infobox
AllopurinolChEMBLChEMBL1467 Y1.00infobox
AllopurinolChemSpider2010 Y1.00infobox
AllopurinolCompTox Dashboard (EPA)DTXSID40225731.00infobox
AllopurinolDrugBankDB00437 Y1.00infobox
AllopurinolECHA InfoCard100.005.6841.00infobox
AllopurinolElimination half-life2 h (oxipurinol 18–30 h)1.00infobox
AllopurinolFormulaC5H4N4O1.00infobox
AllopurinolIUPHAR/BPS67951.00infobox
AllopurinolKEGGD00224 Y1.00infobox
AllopurinolLegal statusAU: S4 (Prescription only)1.00infobox
AllopurinolLegal statusUK: POM (Prescription only)1.00infobox
AllopurinolLegal statusUS: ℞-only1.00infobox
AllopurinolLicense dataUS DailyMed: Allopurinol1.00infobox
AllopurinolMedlinePlusa6826731.00infobox
AllopurinolMetabolismLiver (80% oxipurinol, 10% allopurinol ribosides)1.00infobox
AllopurinolMolar mass136.114 g·mol−11.00infobox
AllopurinolPregnancy categoryAU: B21.00infobox
AllopurinolProtein bindingNegligible1.00infobox
AllopurinolPubChem CID1354019071.00infobox
AllopurinolRoutes of administrationOral, intravenous1.00infobox
AllopurinolTrade namesZyloprim, Caplenal, Zyloric, others1.00infobox
AllopurinolUNII63CZ7GJN5I1.00infobox
Allopurinolis amedication used to decrease high blood uric acid levels0.90text
Allopurinolis ageneric drug sold under a variety of brand names0.90text

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