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Promethazine: History, Community, Culture & Applications

Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, nausea, and vomiting. It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational…

Language: English [EN]
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Promethazine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Promethazine.

Related topics
117
Source areas
8
Connected nodes
125
Extracted relationships
99
Concept neighborhoods
27
Bridge connections
125

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Society and culture · 26 topics
Overview · 21 topics
Overdose · 18 topics
Pharmacology · 17 topics
Side effects · 14 topics
Medical uses · 13 topics
Chemistry · 4 topics
History · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
None-Very low
AHFS/Drugs.com
Monograph
ATC code
D04AA10 (WHO) R06AD02 (WHO)
Bioavailability
88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability
CAS Number
60-87-7 Y 58-33-3 (HCl)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Overdose

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Promethazine connects Entity context

The extracted context around Promethazine shows recurring relationship patterns in the source. For example, Promethazine → AMPA, Another, Both, D2, Despite, EC50, H1, However, HT2A, HT2C, It, Ki, New, NMDA Another extracted example is Promethazine → Diana Levine, Drug Administration, FDA, In, IV, IV-push, Supreme Court, The, The Supreme Court, US Food, US Supreme Court, Wyeth, Wyeth's Phenergan. Use these groups to spot repeated connection types before inspecting the individual relationships.

Promethazine

Top relations

related to Pharmacology · 14
Promethazine → AMPA, Another, Both, D2, Despite, EC50, H1, However, HT2A, HT2C, It, Ki, New, NMDA
related to Product liability lawsuit · 13
Promethazine → Diana Levine, Drug Administration, FDA, In, IV, IV-push, Supreme Court, The, The Supreme Court, US Food, US Supreme Court, Wyeth, Wyeth's Phenergan
related to Tissue necrosis risks specific to the injectable form · 8
Promethazine → Injectable, Institute, One, Safe Medication Practices, Severe, Supreme Court, United States, When
related to Medical uses · 7
Promethazine → For, In, It, Second-choice, SedationIn Germany, The, UK
Legal status · 6
Promethazine → AU: S3 (Pharmacist only), CA: OTC, NZ: OTC -Pharmacist only, South Africa: S5 IV, S2 oral; Sweden: Rx-only, UK: P (Pharmacy medicines) (POM when injection), US: ℞-only
related to Overdose · 5
Promethazine → Anticholinergic, Atypically, CNS, Other, Treatment
related to history · 4
Promethazine → Paul Charpentier, Rhone-Poulenc, Sanofi, The
is a · 3
Promethazine → chiral compound, drug of first choice, vesicant and is capable of damaging blood vessel intima
related to Chemistry · 3
Promethazine → Its, Slow, Solid
related to Recreational use · 2
Promethazine → Sprite, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

use effects drug used also symptoms due injection anticholinergic may side including medical phenergan mouth names pregnancy include many brand

Promethazine relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around Promethazine. Examples in this analysis include Promethazine → 3D model (JSmol) → Interactive image and Promethazine → Addiction liability → None-Very low. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Promethazine3D model (JSmol)Interactive image1.00infobox
PromethazineAddiction liabilityNone-Very low1.00infobox
PromethazineAHFS/Drugs.comMonograph1.00infobox
PromethazineATC codeD04AA10 (WHO) R06AD02 (WHO)1.00infobox
PromethazineBioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability1.00infobox
PromethazineCAS Number60-87-7 Y 58-33-3 (HCl)1.00infobox
PromethazineChEBICHEBI:8461 Y1.00infobox
PromethazineChEMBLChEMBL643 Y1.00infobox
PromethazineChemSpider4758 Y1.00infobox
PromethazineChiralityRacemic mixture1.00infobox
PromethazineCompTox Dashboard (EPA)DTXSID70235181.00infobox
PromethazineDependence liabilityLow1.00infobox
PromethazineDrugBankDB01069 Y1.00infobox
PromethazineDuration of action4–6 hours (sometimes up to 12 hours)1.00infobox
PromethazineECHA InfoCard100.000.4451.00infobox
PromethazineElimination half-life10–19 hours1.00infobox
PromethazineExcretionKidney and Bile duct1.00infobox
PromethazineFormulaC17H20N2S1.00infobox
PromethazineIUPHAR/BPS72821.00infobox
PromethazineKEGGD00494 Y1.00infobox
PromethazineLegal statusAU: S3 (Pharmacist only)1.00infobox
PromethazineLegal statusCA: OTC1.00infobox
PromethazineLegal statusNZ: OTC -Pharmacist only1.00infobox
PromethazineLegal statusUK: P (Pharmacy medicines) (POM when injection)1.00infobox
PromethazineLegal statusUS: ℞-only1.00infobox
PromethazineLegal statusSouth Africa: S5 IV, S2 oral; Sweden: Rx-only1.00infobox
PromethazineLicense dataUS DailyMed: Promethazine1.00infobox
PromethazineMedlinePlusa6822841.00infobox
PromethazineMetabolismLiver glucuronidation and sulfoxidation1.00infobox
PromethazineMetabolitesPromethazine Sulphoxide, Desmethylpromethazine, Promethazine Hydroxy1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Promethazine bring nearby vocabulary together. In this analysis, examples include Use, Injection and Including. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Promethazine
    • Use
    • Injection
    • Including
    • Effects
    • Drug
    • Phenothiazine
    • Pregnancy
    • Uk
    • Severe
    • Us
    • Due
    • Used
  • promethazine
    • Use
    • Injection
    • Including
    • Effects
    • Drug
    • Phenothiazine
    • Pregnancy
    • Uk
    • Severe
    • Us
    • Due
    • Used
  • by mouth
    • Anticholinergic
    • Injection
    • Side
    • Effects
    • Liability
    • Depression
    • Medical
    • Nausea
    • Overdose
    • Pregnancy
    • Recreational
    • Uk
  • side effects
    • Side
    • Include
    • Mouth
    • Due
    • Symptoms
    • Including
    • Administration
    • Liability
    • Us
    • Anticholinergic
    • Depression
    • May
  • dry mouth
    • Anticholinergic
    • Injection
    • Side
    • Effects
    • Liability
    • Depression
    • Medical
    • Nausea
    • Overdose
    • Pregnancy
    • Recreational
    • Uk
  • us food and drug administration
    • Uk
    • Us
    • Injection
    • Liability
    • Resulting
    • Severe
    • Associated
    • Depression
    • Effects
    • Medical
    • Overdose
    • Pregnancy
  • substantive due process
    • Depression
    • Include
    • Effects
    • Side
    • Including
    • Use
    • Nausea
    • Uk
    • Court
    • Many
    • Mouth
    • Resulting
  • recreational use
    • Names
    • Pregnancy
    • Liability
    • Medical
    • Use
    • Overdose
    • Uk
    • Injection
    • Administration
    • Due
    • Mouth
    • Us

Connections between topic areas Semantic bridges

For Promethazine, one of the stronger structural bridges in this analysis connects Promethazine with Society and culture. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PromethazineSociety and culture · splits 99 ⟂ 27
PromethazineOverview · splits 104 ⟂ 22
PromethazineOverdose · splits 107 ⟂ 19
PromethazinePharmacology · splits 108 ⟂ 18
PromethazineSide effects · splits 111 ⟂ 15
PromethazineMedical uses · splits 112 ⟂ 14
PromethazineChemistry · splits 121 ⟂ 5
PromethazineHistory · splits 121 ⟂ 5

Map overview Semantic statistics

Promethazine

Nodes126
Edges125
Triples99
Avg. degree1.98
Density0.015873
Components1

Source & methodology

TTTA analyzes the structure around Promethazine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Promethazine · EN edition · Analysis: TopicsToTalkAbout

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