Find related topics. | Discover entities. | See connections. | Build a topical map.
Building topical map: Starting…
Repaglinide: History, Drug interactions & Pharmacology
Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is a medication used in addition to diet and exercise for blood sugar control in type 2 diabetes. The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas; like other antidiabetic…
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
Repaglinide topic overview
The analysis highlights History, Drug interactions and Pharmacology as prominent areas in the source structure around Repaglinide.
Related topics
31
Source areas
5
Connected nodes
36
Extracted relationships
100
Concept neighborhoods
17
Bridge connections
36
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Drug interactions · 9 topics
Pharmacology · 7 topics
History · 6 topics
Overview · 5 topics
Intellectual property · 4 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A10BX02 (WHO)
Bioavailability
56% (oral)
CAS Number
135062-02-1 Y
ChEMBL
ChEMBL1272 Y
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Repaglinide connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Repaglinide shows recurring relationship patterns in the source. For example, Repaglinide → April, Biberach, Boehringer, Boehringer Ingelheim, December, Dr Karl Thomae GmbH, Drug Administration, FDA, Food, German, Germany, Investigational New Drug, It, July, NDA, New Drug Application, Novo Nordisk, Prandin, Precursor, Riß Another extracted example is Repaglinide → After, Hatch-Waxman Act, In February, In January, January, June, March, May, NDA, November, Novo Nordisk, Novo Nordisk's, Patent, Patents, Prandin's, Previously, Prior, RE37035, September, This. Use these groups to spot repeated connection types before inspecting the individual relationships.
Repaglinide
Top relations
related to history· 22
Repaglinide → April, Biberach, Boehringer, Boehringer Ingelheim, December, Dr Karl Thomae GmbH, Drug Administration, FDA, Food, German, Germany, Investigational New Drug, It, July, NDA, New Drug Application, Novo Nordisk, Prandin, Precursor, Riß
related to Intellectual property· 21
Repaglinide → After, Hatch-Waxman Act, In February, In January, January, June, March, May, NDA, November, Novo Nordisk, Novo Nordisk's, Patent, Patents, Prandin's, Previously, Prior, RE37035, September, This
Repaglinide → Administration, Co-administration, CYP2C8, CYP3A4, In
related to External links· 5
Repaglinide → Archived, Drug Information Portal, January, Medicine, National Library
related to Pharmacokinetics· 4
Repaglinide → Absorption, Bioavailability, Distribution, The
License data· 3
Repaglinide → EU EMA: by INN, US DailyMed: Repaglinide, US FDA: Prandin
related to Mechanism of action· 3
Repaglinide → ATP-dependent, It, This
related to Special populations· 3
Repaglinide → Caution, Data, Pregnancy
is a· 2
Repaglinide → antidiabetic drug in the class of medications known as meglitinides, medication used in addition to diet and exercise for blood sugar control in type 2 diabetes
Important terminology
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 100 structured relationships around Repaglinide. Examples in this analysis include Repaglinide → 3D model (JSmol) → Interactive image and Repaglinide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Repaglinide
3D model (JSmol)
Interactive image
1.00
infobox
Repaglinide
AHFS/Drugs.com
Monograph
1.00
infobox
Repaglinide
ATC code
A10BX02 (WHO)
1.00
infobox
Repaglinide
Bioavailability
56% (oral)
1.00
infobox
Repaglinide
CAS Number
135062-02-1 Y
1.00
infobox
Repaglinide
ChEMBL
ChEMBL1272 Y
1.00
infobox
Repaglinide
ChemSpider
59377 Y
1.00
infobox
Repaglinide
CompTox Dashboard (EPA)
DTXSID3023552
1.00
infobox
Repaglinide
DrugBank
DB00912 Y
1.00
infobox
Repaglinide
ECHA InfoCard
100.158.190
1.00
infobox
Repaglinide
Elimination half-life
1 hour
1.00
infobox
Repaglinide
Excretion
Fecal (90%) and kidney (8%)
1.00
infobox
Repaglinide
Formula
C27H36N2O4
1.00
infobox
Repaglinide
IUPHAR/BPS
6841
1.00
infobox
Repaglinide
KEGG
D00594 Y
1.00
infobox
Repaglinide
Legal status
AU: S4 (Prescription only)
1.00
infobox
Repaglinide
Legal status
CA: ℞-only
1.00
infobox
Repaglinide
Legal status
UK: POM (Prescription only)
1.00
infobox
Repaglinide
Legal status
US: ℞-only
1.00
infobox
Repaglinide
Legal status
EU: Rx-only
1.00
infobox
Repaglinide
License data
EU EMA: by INN
1.00
infobox
Repaglinide
License data
US DailyMed: Repaglinide
1.00
infobox
Repaglinide
License data
US FDA: Prandin
1.00
infobox
Repaglinide
MedlinePlus
a600010
1.00
infobox
Repaglinide
Melting point
126 to 128 °C (259 to 262 °F)
1.00
infobox
Repaglinide
Metabolism
Liver oxidation and glucuronidation (CYP3A4-mediated)
1.00
infobox
Repaglinide
Molar mass
452.595 g·mol−1
1.00
infobox
Repaglinide
Pregnancy category
AU: C
1.00
infobox
Repaglinide
Protein binding
>98%
1.00
infobox
Repaglinide
PubChem CID
65981
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Repaglinide bring nearby vocabulary together. In this analysis, examples include Drugs, Hypoglycemia and Novo. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Repaglinide
Drugs
Hypoglycemia
Novo
Administration
Diabetes
Lead
Mechanism
One
Pregnancy
Type
Action
May
repaglinide
Drugs
Hypoglycemia
Novo
Administration
Diabetes
Lead
Mechanism
One
Pregnancy
Type
Action
May
antidiabetic drug
Class
Pancreas
Fda
Insulin
Mechanism
Repaglinide
Action
Cells
Hypoglycemia
Administration
Application
Diabetes
investigational new drug
Novo
Nordisk
Fda
Patent
Repaglinide
Class
Administration
Application
Diabetes
Pregnancy
Type
Prandin
food and drug administration
Fda
Drugs
Cyp3a4
Japan
Name
Novonorm
Repaglinide
Application
Bioavailability
Class
Diabetes
Lead
new drug application
Fda
Novo
Nordisk
New
Patent
Repaglinide
Class
Term
Administration
Application
Diabetes
Drug
drug interactions
Fda
Repaglinide
Class
Administration
Application
Diabetes
Pregnancy
Type
Prandin
Drugs
New
Nordisk
medication
Diabetes
Liver
Type
Blood
Cyp3a4
Japan
Name
Novonorm
Administration
Bioavailability
Fda
Mechanism
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Repaglinide, one of the stronger structural bridges in this analysis connects Repaglinide with Drug interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Repaglinide
Nodes37
Edges36
Triples100
Avg. degree1.95
Density0.054054
Components1
Source & methodology
TTTA analyzes the structure around Repaglinide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Drug interactions & Pharmacology, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
