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Repaglinide

Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is a medication used in addition to diet and exercise for blood sugar control in type 2 diabetes. The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas; like other antidiabetic…

History, Drug interactions & Pharmacology

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A10BX02 (WHO)
Bioavailability
56% (oral)
CAS Number
135062-02-1 Y
ChEMBL
ChEMBL1272 Y

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Overview

Drug interactions

Pharmacology

History

Intellectual property

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Map overview Semantic statistics

Repaglinide

Nodes37
Edges36
Triples100
Avg. degree1.95
Density0.054054
Components1

How this topic connects Entity context

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Repaglinide

Top relations

related to history · 22
Repaglinide → April, Biberach, Boehringer, Boehringer Ingelheim, December, Dr Karl Thomae GmbH, Drug Administration, FDA, Food, German, Germany, Investigational New Drug, It, July, NDA, New Drug Application, Novo Nordisk, Prandin, Precursor, Riß
related to Intellectual property · 21
Repaglinide → After, Hatch-Waxman Act, In February, In January, January, June, March, May, NDA, November, Novo Nordisk, Novo Nordisk's, Patent, Patents, Prandin's, Previously, Prior, RE37035, September, This
Legal status · 5
Repaglinide → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Drug interactions · 5
Repaglinide → Administration, Co-administration, CYP2C8, CYP3A4, In
related to External links · 5
Repaglinide → Archived, Drug Information Portal, January, Medicine, National Library
related to Pharmacokinetics · 4
Repaglinide → Absorption, Bioavailability, Distribution, The
License data · 3
Repaglinide → EU EMA: by INN, US DailyMed: Repaglinide, US FDA: Prandin
related to Mechanism of action · 3
Repaglinide → ATP-dependent, It, This
related to Special populations · 3
Repaglinide → Caution, Data, Pregnancy
is a · 2
Repaglinide → antidiabetic drug in the class of medications known as meglitinides, medication used in addition to diet and exercise for blood sugar control in type 2 diabetes

Important terminology Word statistics

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Important terminology

patent drug novo drugs hypoglycemia nordisk prandin action new blood cells insulin mechanism medication bioavailability may type diabetes antidiabetic japan

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Repaglinide3D model (JSmol)Interactive image1.00infobox
RepaglinideAHFS/Drugs.comMonograph1.00infobox
RepaglinideATC codeA10BX02 (WHO)1.00infobox
RepaglinideBioavailability56% (oral)1.00infobox
RepaglinideCAS Number135062-02-1 Y1.00infobox
RepaglinideChEMBLChEMBL1272 Y1.00infobox
RepaglinideChemSpider59377 Y1.00infobox
RepaglinideCompTox Dashboard (EPA)DTXSID30235521.00infobox
RepaglinideDrugBankDB00912 Y1.00infobox
RepaglinideECHA InfoCard100.158.1901.00infobox
RepaglinideElimination half-life1 hour1.00infobox
RepaglinideExcretionFecal (90%) and kidney (8%)1.00infobox
RepaglinideFormulaC27H36N2O41.00infobox
RepaglinideIUPHAR/BPS68411.00infobox
RepaglinideKEGGD00594 Y1.00infobox
RepaglinideLegal statusAU: S4 (Prescription only)1.00infobox
RepaglinideLegal statusCA: ℞-only1.00infobox
RepaglinideLegal statusUK: POM (Prescription only)1.00infobox
RepaglinideLegal statusUS: ℞-only1.00infobox
RepaglinideLegal statusEU: Rx-only1.00infobox
RepaglinideLicense dataEU EMA: by INN1.00infobox
RepaglinideLicense dataUS DailyMed: Repaglinide1.00infobox
RepaglinideLicense dataUS FDA: Prandin1.00infobox
RepaglinideMedlinePlusa6000101.00infobox
RepaglinideMelting point126 to 128 °C (259 to 262 °F)1.00infobox
RepaglinideMetabolismLiver oxidation and glucuronidation (CYP3A4-mediated)1.00infobox
RepaglinideMolar mass452.595 g·mol−11.00infobox
RepaglinidePregnancy categoryAU: C1.00infobox
RepaglinideProtein binding>98%1.00infobox
RepaglinidePubChem CID659811.00infobox

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