CYP2C8

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CYP2C8 topic overview

The analysis highlights Epoxygenase activity, Ligands and Overview as prominent areas in the source structure around CYP2C8.

Related topics: 23
Source areas: 3
Connected nodes: 26
Extracted relationships: 89
Concept neighborhoods: 17
Bridge connections: 26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Epoxygenase activity · 9 topics

Overview · 9 topics

Ligands · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.14.14.1: ↗
Aliases: CYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ
Band: 10q23.33 · 19|19 C3
Bgee: right lobe of liver · sperm · pancreatic ductal cell · right uterine tube · testicle
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Ligands

Substrates Enzyme substrate
Inhibitors Enzyme induction and inhibition
Potency Potency (pharmacology)
AUC values Area under the curve (pharmacokinetics)
Clearance Clearance (medicine)

Epoxygenase activity

Alkene
Epoxyeicosatrienoic acids Epoxyeicosatrienoic acid
Vernolic acid
Coronaric acid
Epoxydocosapentaenoic acids Epoxydocosapentaenoic acid
CYP2C9
CYP2C19
CYP2J2
CYP2S1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CYP2C8 connects Entity context

The extracted context around CYP2C8 shows recurring relationship patterns in the source. For example, CYP2C8 → arachidonic acid epoxygenase activity, aromatase activity, caffeine oxidase activity, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, epoxygenase P450 pathway, estrogen 16-alpha-hydroxylase activity, estrogen metabolic process, heme binding, intracellular membrane-bounded organelle, iron ion binding, lipid hydroxylation, long-chain fatty acid biosynthetic process, membrane, metal ion binding, monooxygenase activity, omega-hydroxylase P450 pathway, organelle membrane, organic acid metabolic process Another extracted example is CYP2C8 → anterior pituitary, body of stomach, gallbladder, gonad, left adrenal cortex, liver, pancreatic ductal cell, right lobe of liver, right uterine tube, sperm, testicle, thoracic diaphragm. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 27

CYP2C8 → arachidonic acid epoxygenase activity, aromatase activity, caffeine oxidase activity, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, epoxygenase P450 pathway, estrogen 16-alpha-hydroxylase activity, estrogen metabolic process, heme binding, intracellular membrane-bounded organelle, iron ion binding, lipid hydroxylation, long-chain fatty acid biosynthetic process, membrane, metal ion binding, monooxygenase activity, omega-hydroxylase P450 pathway, organelle membrane, organic acid metabolic process

Bgee · 12

CYP2C8 → anterior pituitary, body of stomach, gallbladder, gonad, left adrenal cortex, liver, pancreatic ductal cell, right lobe of liver, right uterine tube, sperm, testicle, thoracic diaphragm

RNA expression pattern · 12

CYP2C8 → anterior pituitary, body of stomach, gallbladder, gonad, left adrenal cortex, liver, pancreatic ductal cell, right lobe of liver, right uterine tube, sperm, testicle, thoracic diaphragm

related to Epoxygenase activity · 9

CYP2C8 → Along, CYP2C19, CYP2C9, CYP2J2, CYP2S1, EDPs, EEQs, EETs, It

Band · 2

CYP2C8 → 10q23.33, 19|19 C3

Chr. · 2

CYP2C8 → Chromosome 10 (human), Chromosome 19 (mouse)

End · 2

CYP2C8 → 39,556,973 bp, 95,069,497 bp

related to External links · 2

CYP2C8 → Human CYP2C8, UCSC Genome Browser

related to Ligands · 2

CYP2C8 → Following, Inhibitors

1.14.14.1 · 1

CYP2C8 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human epoxygenase activity chr band cytochrome p450 chromosome 10 also one acid gene location oxidase long-chain fatty arachidonic acids

CYP2C8 relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around CYP2C8. Examples in this analysis include CYP2C8 → 1.14.14.1 → ↗ and CYP2C8 → Aliases → CYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CYP2C8	1.14.14.1	↗	1.00	infobox
CYP2C8	Aliases	CYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM	1.00	infobox
CYP2C8	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ	1.00	infobox
CYP2C8	Band	10q23.33	1.00	infobox
CYP2C8	Band	19\|19 C3	1.00	infobox
CYP2C8	Bgee	right lobe of liver	1.00	infobox
CYP2C8	Bgee	sperm	1.00	infobox
CYP2C8	Bgee	pancreatic ductal cell	1.00	infobox
CYP2C8	Bgee	right uterine tube	1.00	infobox
CYP2C8	Bgee	testicle	1.00	infobox
CYP2C8	Bgee	gallbladder	1.00	infobox
CYP2C8	Bgee	anterior pituitary	1.00	infobox
CYP2C8	Bgee	left adrenal cortex	1.00	infobox
CYP2C8	Bgee	gonad	1.00	infobox
CYP2C8	Bgee	body of stomach	1.00	infobox
CYP2C8	Bgee	liver	1.00	infobox
CYP2C8	Bgee	thoracic diaphragm	1.00	infobox
CYP2C8	BioGPS	More reference expression data	1.00	infobox
CYP2C8	Chr.	Chromosome 10 (human)	1.00	infobox
CYP2C8	Chr.	Chromosome 19 (mouse)	1.00	infobox
CYP2C8	Databases	NCBI: entry; OMA: entry	1.00	infobox
CYP2C8	End	95,069,497 bp	1.00	infobox
CYP2C8	End	39,556,973 bp	1.00	infobox
CYP2C8	Ensembl	ENSG00000138115	1.00	infobox
CYP2C8	Entrez	1558	1.00	infobox
CYP2C8	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc1.14.14.1↗↗↗↗	1.00	infobox
CYP2C8	External IDs	OMIM: 601129; MGI: 1306818; GeneCards: CYP2C8	1.00	infobox
CYP2C8	Gene location (Human)	Gene location (Human)Chr.Chromosome 10 (human)Band10q23.33Start95,036,772 bpEnd95,069,497 bp	1.00	infobox
CYP2C8	Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 19 (mouse)Band19\|19 C3Start39,499,306 bpEnd39,556,973 bp	1.00	infobox
CYP2C8	Gene ontology	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CYP2C8 bring nearby vocabulary together. In this analysis, examples include P450, Epoxygenase and Oxidase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CYP2C8
- P450
- Epoxygenase
- Oxidase
- Activity
- Cytochrome
- Gene
- Location
- Human
- One
- Body
- Member
- Fatty
cyp2c8
- P450
- Epoxygenase
- Oxidase
- Activity
- Cytochrome
- Gene
- Location
- Human
- One
- Body
- Member
- Fatty
cytochrome p450
- Oxidase
- Gene
- Location
- P450
- Epoxygenase
- Human
- Member
- P4502c8
- Cyp2c8
- Activity
- Also
- Chromosome
polyunsaturated fatty acids
- Long-chain
- Possesses
- Also
- Metabolizes
- Polyunsaturated
- Arachidonic
- Fatty
- Linoleic
- Acid
- Activity
- Epoxygenase
- One
arachidonic acid
- Acid
- Arachidonic
- Linoleic
- Metabolizes
- Epoxides
- Fatty
- Long-chain
- Acids
- Activity
- Also
- Epoxygenase
- Body
eicosapentaenoic acid
- Arachidonic
- Linoleic
- Epoxides
- Metabolizes
- Acids
- Fatty
- Long-chain
- Activity
- Also
- Epoxygenase
- Cyp2c8
- Body
docosahexaenoic acid
- Arachidonic
- Linoleic
- Epoxides
- Metabolizes
- Acids
- Fatty
- Long-chain
- Activity
- Also
- Epoxygenase
- Cyp2c8
- Body
linoleic acid
- Arachidonic
- Linoleic
- Epoxides
- Metabolizes
- Acids
- Fatty
- Long-chain
- Activity
- Also
- Epoxygenase
- P4502c8
- Polyunsaturated

Connections between topic areas Semantic bridges

For CYP2C8, one of the stronger structural bridges in this analysis connects CYP2C8 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CYP2C8 — Overview · splits 17 ⟂ 10

CYP2C8 — Epoxygenase activity · splits 17 ⟂ 10

CYP2C8 — Ligands · splits 21 ⟂ 6

Map overview Semantic statistics

CYP2C8

Nodes27

Edges26

Triples89

Avg. degree1.93

Density0.074074

Components1

Source & methodology

TTTA analyzes the structure around CYP2C8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Epoxygenase activity, Ligands & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CYP2C8 · EN edition · Analysis: TopicsToTalkAbout