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CYP2C8

Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome P4502C8 also possesses epoxygenase activity, i.e. it metabolizes long-chain polyunsaturated fatty acids, e.g. arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and linoleic acid to…

Epoxygenase activity, Ligands & Overview

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1.14.14.1
↗
Aliases
CYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ
Band
10q23.33 · 19|19 C3
Bgee
right lobe of liver · sperm · pancreatic ductal cell · right uterine tube · testicle
BioGPS
More reference expression data

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Overview

Ligands

Epoxygenase activity

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CYP2C8

Nodes27
Edges26
Triples89
Avg. degree1.93
Density0.074074
Components1

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CYP2C8

Top relations

Gene ontology · 27
CYP2C8 → arachidonic acid epoxygenase activity, aromatase activity, caffeine oxidase activity, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, epoxygenase P450 pathway, estrogen 16-alpha-hydroxylase activity, estrogen metabolic process, heme binding, intracellular membrane-bounded organelle, iron ion binding, lipid hydroxylation, long-chain fatty acid biosynthetic process, membrane, metal ion binding, monooxygenase activity, omega-hydroxylase P450 pathway, organelle membrane, organic acid metabolic process
Bgee · 12
CYP2C8 → anterior pituitary, body of stomach, gallbladder, gonad, left adrenal cortex, liver, pancreatic ductal cell, right lobe of liver, right uterine tube, sperm, testicle, thoracic diaphragm
RNA expression pattern · 12
CYP2C8 → anterior pituitary, body of stomach, gallbladder, gonad, left adrenal cortex, liver, pancreatic ductal cell, right lobe of liver, right uterine tube, sperm, testicle, thoracic diaphragm
related to Epoxygenase activity · 9
CYP2C8 → Along, CYP2C19, CYP2C9, CYP2J2, CYP2S1, EDPs, EEQs, EETs, It
Band · 2
CYP2C8 → 10q23.33, 19|19 C3
Chr. · 2
CYP2C8 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
CYP2C8 → 39,556,973 bp, 95,069,497 bp
related to External links · 2
CYP2C8 → Human CYP2C8, UCSC Genome Browser
related to Ligands · 2
CYP2C8 → Following, Inhibitors
1.14.14.1 · 1
CYP2C8 → ↗

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Important terminology

bp human epoxygenase activity chr band cytochrome p450 chromosome 10 also one acid gene location oxidase long-chain fatty arachidonic acids

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CYP2C81.14.14.1↗1.00infobox
CYP2C8AliasesCYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM1.00infobox
CYP2C8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ1.00infobox
CYP2C8Band10q23.331.00infobox
CYP2C8Band19|19 C31.00infobox
CYP2C8Bgeeright lobe of liver1.00infobox
CYP2C8Bgeesperm1.00infobox
CYP2C8Bgeepancreatic ductal cell1.00infobox
CYP2C8Bgeeright uterine tube1.00infobox
CYP2C8Bgeetesticle1.00infobox
CYP2C8Bgeegallbladder1.00infobox
CYP2C8Bgeeanterior pituitary1.00infobox
CYP2C8Bgeeleft adrenal cortex1.00infobox
CYP2C8Bgeegonad1.00infobox
CYP2C8Bgeebody of stomach1.00infobox
CYP2C8Bgeeliver1.00infobox
CYP2C8Bgeethoracic diaphragm1.00infobox
CYP2C8BioGPSMore reference expression data1.00infobox
CYP2C8Chr.Chromosome 10 (human)1.00infobox
CYP2C8Chr.Chromosome 19 (mouse)1.00infobox
CYP2C8DatabasesNCBI: entry; OMA: entry1.00infobox
CYP2C8End95,069,497 bp1.00infobox
CYP2C8End39,556,973 bp1.00infobox
CYP2C8EnsemblENSG000001381151.00infobox
CYP2C8Entrez15581.00infobox
CYP2C8Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc1.14.14.1↗↗↗↗1.00infobox
CYP2C8External IDsOMIM: 601129; MGI: 1306818; GeneCards: CYP2C81.00infobox
CYP2C8Gene location (Human)Gene location (Human)Chr.Chromosome 10 (human)Band10q23.33Start95,036,772 bpEnd95,069,497 bp1.00infobox
CYP2C8Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 19 (mouse)Band19|19 C3Start39,499,306 bpEnd39,556,973 bp1.00infobox
CYP2C8Gene ontologyoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen1.00infobox

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