CYP2A6

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Induction

Inducible Phenobarbital Rifampicin

3 related topics

Distribution

Endoplasmic reticulum

1 related topics

Overview

Cytochrome P450 Xenobiotics Nicotine Cotinine Coumarin

5 related topics

Key facts & relationships

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Aliases: CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, cytochrome P450 family 2 subfamily A member 6
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ
Band: 19q13.2 · 7 A3|7 15.54 cM
Bgee: right lobe of liver · paraflocculus of cerebellum · middle frontal gyrus · frontal pole · Brodmann area 10
BioGPS: n/a
Chr.: Chromosome 19 (human) · Chromosome 7 (mouse)

Topics to explore

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Overview

Distribution

Endoplasmic reticulum

Induction

Inducible Enzyme induction and inhibition
Phenobarbital
Rifampicin

Advanced semantic analysis

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Map overview Semantic statistics

Nodes13

Edges12

Triples92

Avg. degree1.85

Density0.153846

Components1

How this topic connects Entity context

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CYP2A6

Top relations

Gene ontology · 24

CYP2A6 → arachidonic acid epoxygenase activity, coumarin 7-hydroxylase activity, coumarin catabolic process, coumarin metabolic process, cytoplasm, cytoplasmic microtubule, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, heme binding, intracellular membrane-bounded organelle, iron ion binding, membrane, metal ion binding, monooxygenase activity, organelle membrane, organic acid metabolic process, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Bgee · 19

CYP2A6 → Brodmann area 10, cerebellar vermis, esophagus, frontal pole, hepatobiliary system, human kidney, liver, male germ cell, middle frontal gyrus, nasal epithelium, olfactory epithelium, paraflocculus of cerebellum, proximal tubule, respiratory epithelium, right kidney, right lobe of liver, sperm, thalamus, thymus

RNA expression pattern · 19

related to External links · 4

CYP2A6 → CPA6, Human CPA6, Human CYP2A6, UCSC Genome Browser

Band · 2

CYP2A6 → 19q13.2, 7 A3|7 15.54 cM

Chr. · 2

CYP2A6 → Chromosome 19 (human), Chromosome 7 (mouse)

End · 2

CYP2A6 → 26,542,973 bp, 40,850,447 bp

is a · 2

CYP2A6 → only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, primary enzyme responsible for the oxidation of nicotine and cotinine

Aliases · 1

CYP2A6 → CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, cytochrome P450 family 2 subfamily A member 6

Available structures · 1

CYP2A6 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ

Important terminology Word statistics

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Important terminology

human gene bp p450 chromosome chr band location cytochrome 19 enzyme also involved metabolism body coumarin mouse ucsc member system

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
CYP2A6	Aliases	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, cytochrome P450 family 2 subfamily A member 6	1.00	infobox
CYP2A6	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ	1.00	infobox
CYP2A6	Band	19q13.2	1.00	infobox
CYP2A6	Band	7 A3\|7 15.54 cM	1.00	infobox
CYP2A6	Bgee	right lobe of liver	1.00	infobox
CYP2A6	Bgee	paraflocculus of cerebellum	1.00	infobox
CYP2A6	Bgee	middle frontal gyrus	1.00	infobox
CYP2A6	Bgee	frontal pole	1.00	infobox
CYP2A6	Bgee	Brodmann area 10	1.00	infobox
CYP2A6	Bgee	nasal epithelium	1.00	infobox
CYP2A6	Bgee	cerebellar vermis	1.00	infobox
CYP2A6	Bgee	male germ cell	1.00	infobox
CYP2A6	Bgee	sperm	1.00	infobox
CYP2A6	Bgee	thalamus	1.00	infobox
CYP2A6	Bgee	proximal tubule	1.00	infobox
CYP2A6	Bgee	human kidney	1.00	infobox
CYP2A6	Bgee	right kidney	1.00	infobox
CYP2A6	Bgee	hepatobiliary system	1.00	infobox
CYP2A6	Bgee	liver	1.00	infobox
CYP2A6	Bgee	esophagus	1.00	infobox
CYP2A6	Bgee	respiratory epithelium	1.00	infobox
CYP2A6	Bgee	thymus	1.00	infobox
CYP2A6	Bgee	olfactory epithelium	1.00	infobox
CYP2A6	BioGPS	n/a	1.00	infobox
CYP2A6	Chr.	Chromosome 19 (human)	1.00	infobox
CYP2A6	Chr.	Chromosome 7 (mouse)	1.00	infobox
CYP2A6	Databases	NCBI: entry; OMA: entry	1.00	infobox
CYP2A6	End	40,850,447 bp	1.00	infobox
CYP2A6	End	26,542,973 bp	1.00	infobox
CYP2A6	Ensembl	ENSG00000255974	1.00	infobox

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