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Losartan

Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Besides hypertension, it is also used in diabetic kidney disease, heart failure, and left ventricular enlargement. It…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C09CA01 (WHO)
Bioavailability
25–35%
CAS Number
114798-26-4 Y
ChEBI
CHEBI:6541 Y

Topics to explore

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Overview

Chemistry

Medical uses

Adverse effects

Mechanism of action

Pharmacokinetics

Advanced semantic analysis

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Map overview Semantic statistics

Losartan

Nodes80
Edges79
Triples104
Avg. degree1.98
Density0.025
Components1

How this topic connects Entity context

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Losartan

Top relations

related to Contamination · 15
Losartan → API, Between November, Camber Pharmaceuticals, FDA, Hetero Labs, Legacy Pharmaceutical Packaging, Macleods Pharmaceutical Limited, N-methylnitrosobutyric, N-nitroso-N-methyl-4-aminobutyric, N-nitrosodiethylamine, Sandoz, September, Teva Pharmaceuticals, Torrent Pharmaceuticals, Vivimed Life Sciences
related to Further reading · 13
Losartan → Al-Majed AR, Assiri, Clin Pharmacokinet, Clinical, Comprehensive Profile, Gehr TW, Ghosh, Khalil NY, PMID, Profiles Drug Subst Excip, Relat Methodol, S2CID, Sica DA
related to Mechanism of action · 12
Losartan → ACE, Aldosterone, All, Angiotensin II, As, AT1, II, Reduction, Renin, Sodium, Therefore, They
related to External links · 7
Losartan → April, Guidance, Health Canada, Media, Nitrosamine, Wikimedia Commons, Wiktionary-logo-en-v2
has effect · 6
Losartan → Adverse, Anemia, As, Electrolyte, People, The
related to Medical uses · 6
Losartan → ACE, Although, II, It, One, The
related to Pharmacokinetics · 5
Losartan → About, AT1, EXP3174, In, Losartan's
related to Pregnancy · 5
Losartan → Drug Administration, FDA, In October, US Food, Using
related to Chemistry · 3
Losartan → C22H23ClN6O, Its, The
Legal status · 2
Losartan → In general: ℞ (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

blood angiotensin may pressure medication effects ii kidney adverse receptor used use renin potassium pregnancy hypertension occur drug hours acid

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Losartan3D model (JSmol)Interactive image1.00infobox
LosartanAHFS/Drugs.comMonograph1.00infobox
LosartanATC codeC09CA01 (WHO)1.00infobox
LosartanBioavailability25–35%1.00infobox
LosartanCAS Number114798-26-4 Y1.00infobox
LosartanChEBICHEBI:6541 Y1.00infobox
LosartanChEMBLChEMBL191 Y1.00infobox
LosartanChemSpider3824 Y1.00infobox
LosartanCompTox Dashboard (EPA)DTXSID70232271.00infobox
LosartanDrug classAngiotensin II receptor antagonist1.00infobox
LosartanDrugBankDB00678 Y1.00infobox
LosartanECHA InfoCard100.110.5551.00infobox
LosartanElimination half-life1.5–2 hours1.00infobox
LosartanExcretionKidney 13–25%, bile duct 50–60%1.00infobox
LosartanFormulaC22H23ClN6O1.00infobox
LosartanIUPHAR/BPS5901.00infobox
LosartanKEGGD08146 Y1.00infobox
LosartanLegal statusUS: ℞-only1.00infobox
LosartanLegal statusIn general: ℞ (Prescription only)1.00infobox
LosartanLicense dataUS DailyMed: Losartan1.00infobox
LosartanMedlinePlusa6950081.00infobox
LosartanMetabolismLiver (CYP2C9, CYP3A4)1.00infobox
LosartanMolar mass422.92 g·mol−11.00infobox
LosartanPregnancy categoryAU: D1.00infobox
LosartanPronunciation/loʊˈsɑːrtən/ ⓘ1.00infobox
LosartanProtein binding99.7% (primarily albumin)1.00infobox
LosartanPubChem CID39611.00infobox
LosartanRoutes of administrationBy mouth1.00infobox
LosartanTrade namesCozaar, others1.00infobox
LosartanUNIIJMS50MPO891.00infobox

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