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Clobazam: History, Community, Culture & Applications

Clobazam, sold under the brand names Frisium and Onfi, among others, is a long-acting benzodiazepine medication primarily used as an anxiolytic and anticonvulsant. Clobazam is a 1,5-benzodiazepine with unique pharmacological characteristics that was patented in 1968. Clobazam was first synthesized in 1966 and first published in 1969. It was approved in…

Language: English [EN]
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Clobazam topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Clobazam.

Related topics
89
Source areas
7
Connected nodes
96
Extracted relationships
99
Concept neighborhoods
25
Bridge connections
96

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 38 topics
Side effects · 17 topics
Overview · 16 topics
Medical uses · 12 topics
History · 3 topics
Chemistry · 2 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
High[citation needed]
AHFS/Drugs.com
Monograph
ATC code
N05BA09 (WHO)
Bioavailability
Rapidly and extensively absorbed; 87%–95% (oral)
CAS Number
22316-47-8

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Clobazam connects Entity context

The extracted context around Clobazam shows recurring relationship patterns in the source. For example, Clobazam → Cl, CP-1414S, GABA, GABA-mediated, GABAA, GABAergic, It, Like, N-desmethylclobazam, The, They Another extracted example is Clobazam → CYP2B6, CYP2C18, CYP2C19, CYP3A4, Hydroxy-N-desmethylclobazam, Hydroxyclobazam, Hydroxyclobazam The, N-desmethylclobazam, The, While. Use these groups to spot repeated connection types before inspecting the individual relationships.

Clobazam

Top relations

related to Pharmacology · 11
Clobazam → Cl, CP-1414S, GABA, GABA-mediated, GABAA, GABAergic, It, Like, N-desmethylclobazam, The, They
related to Metabolism · 10
Clobazam → CYP2B6, CYP2C18, CYP2C19, CYP3A4, Hydroxy-N-desmethylclobazam, Hydroxyclobazam, Hydroxyclobazam The, N-desmethylclobazam, The, While
Legal status · 9
Clobazam → AU: S4 (Prescription only), BR: Class B1 (Psychoactive drugs), CA: Schedule IV, DE: Prescription only (Anlage III for higher doses), In general: ℞ (Prescription only), NZ: Class C, UK: Class C, UN: Psychotropic Schedule IV, US: Schedule IV
Metabolites · 6
Clobazam → • 4'-Hydroxy-N-desmethylclobazam, • 4'-Hydroxyclobazam, • 9-Hydroxy-N-desmethylclobazam, • N-desmethylclobazam (Norclobazam, 4-oxo-Lofendazam), • N-desmethylclobazam (Norclobazam, 4-oxo-Lofendazam) • N-desmethylclobazam-3',4'-dihydrodiol • 9-Hydroxy-N-desmethylclobazam • 4'-Hydroxy-N-desmethylclobazam • 4'-Hydroxyclobazam, • N-desmethylclobazam-3',4'-dihydrodiol
related to history · 5
Clobazam → Maestretti, Maestretti Research Laboratories, Milan, Roussel Uclaf, Sanofi
related to Anxiety · 4
Clobazam → Frisium, In, It, United Kingdom
related to Dependence and withdrawal · 4
Clobazam → Benzodiazepine, In, The, Withdrawal
related to Epilepsy · 4
Clobazam → As, Canada, Frisium, It
related to Warnings and precautions · 4
Clobazam → FDA, In December, Johnson, Stevens
Excretion · 3
Clobazam → Feces (11%), Kidney (82%), Kidney (82%) Feces (11%)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

benzodiazepine drug approved effects anxiety n-desmethylclobazam epilepsy gabaa receptor use syndrome therapy anticonvulsant withdrawal seizures dependence benzodiazepines addiction metabolite onfi

Clobazam relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around Clobazam. Examples in this analysis include Clobazam → 3D model (JSmol) → Interactive image and Clobazam → Addiction liability → High[citation needed]. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Clobazam3D model (JSmol)Interactive image1.00infobox
ClobazamAddiction liabilityHigh[citation needed]1.00infobox
ClobazamAHFS/Drugs.comMonograph1.00infobox
ClobazamATC codeN05BA09 (WHO)1.00infobox
ClobazamBioavailabilityRapidly and extensively absorbed; 87%–95% (oral)1.00infobox
ClobazamCAS Number22316-47-81.00infobox
ClobazamChEBICHEBI:314131.00infobox
ClobazamChEMBLChEMBL704181.00infobox
ClobazamChemSpider26871.00infobox
ClobazamCompTox Dashboard (EPA)DTXSID20467591.00infobox
ClobazamDependence liabilityHigh[citation needed]1.00infobox
ClobazamDrug classBenzodiazepine, Anticonvulsant1.00infobox
ClobazamDrugBankDB003491.00infobox
ClobazamECHA InfoCard100.040.8101.00infobox
ClobazamElimination half-life• Clobazam: 36–42 hours • N-desmethylclobazam: 71–82 hours1.00infobox
ClobazamElimination half-life• Clobazam: 36–42 hours1.00infobox
ClobazamExcretionKidney (82%) Feces (11%)1.00infobox
ClobazamExcretionKidney (82%)1.00infobox
ClobazamExcretionFeces (11%)1.00infobox
ClobazamFormulaC16H13ClN2O21.00infobox
ClobazamIUPHAR/BPS71491.00infobox
ClobazamKEGGD012531.00infobox
ClobazamLegal statusAU: S4 (Prescription only)1.00infobox
ClobazamLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
ClobazamLegal statusCA: Schedule IV1.00infobox
ClobazamLegal statusDE: Prescription only (Anlage III for higher doses)1.00infobox
ClobazamLegal statusNZ: Class C1.00infobox
ClobazamLegal statusUK: Class C1.00infobox
ClobazamLegal statusUS: Schedule IV1.00infobox
ClobazamLegal statusUN: Psychotropic Schedule IV1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Clobazam bring nearby vocabulary together. In this analysis, examples include Benzodiazepine, Effects and Gabaa. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Clobazam
    • Benzodiazepine
    • Effects
    • Gabaa
    • N-desmethylclobazam
    • Receptor
    • Anticonvulsant
    • Needed
    • Use
    • Approved
    • Binding
    • Frisium
    • Active
  • clobazam
    • Benzodiazepine
    • Effects
    • Gabaa
    • N-desmethylclobazam
    • Receptor
    • Anticonvulsant
    • Needed
    • Use
    • Approved
    • Binding
    • Frisium
    • Active
  • benzodiazepine
    • Anticonvulsant
    • Dependence
    • Effects
    • Withdrawal
    • Class
    • Clobazam
    • Binding
    • Addiction
    • Benzodiazepines
    • Needed
    • Receptor
    • Names
  • anticonvulsant
    • Anxiolytic
    • Names
    • Effects
    • Benzodiazepine
    • Drugs
    • Frisium
    • Onfi
    • Addiction
    • Dependence
    • Higher
    • Needed
    • Withdrawal
  • anxiety
    • Short-term
    • Approved
    • Also
    • Drugs
    • Frisium
    • United
    • Adjunctive
    • Epilepsy
    • Drug
    • Names
    • Class
    • Common
  • adjunctive therapy
    • Therapy
    • Epilepsy
    • Drugs
    • Frisium
    • Onfi
    • United
    • Anxiety
    • Needed
    • Seizures
    • Approved
    • Drug
    • Names
  • food and drug administration
    • Higher
    • Therapy
    • Withdrawal
    • Class
    • Gastaut
    • Lennox
    • N-desmethylclobazam
    • States
    • Also
    • Onfi
    • United
    • Active
  • addiction
    • Dependence
    • Withdrawal
    • Class
    • Common
    • Drugs
    • Anticonvulsant
    • Effects
    • Needed
    • Benzodiazepine
    • Drug
    • Names
    • Also

Connections between topic areas Semantic bridges

For Clobazam, one of the stronger structural bridges in this analysis connects Clobazam with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Clobazam — Pharmacology · splits 58 ⟂ 39
Clobazam — Side effects · splits 79 ⟂ 18
Clobazam — Overview · splits 80 ⟂ 17
Clobazam — Medical uses · splits 84 ⟂ 13
Clobazam — History · splits 93 ⟂ 4
Clobazam — Chemistry · splits 94 ⟂ 3

Map overview Semantic statistics

Clobazam

Nodes97
Edges96
Triples99
Avg. degree1.98
Density0.020619
Components1

Source & methodology

TTTA analyzes the structure around Clobazam to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Clobazam · EN edition · Analysis: TopicsToTalkAbout

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