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Celecoxib

Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. It may also be…

History, Community, Culture & Applications

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Explore the main themes, entities and connections around Celecoxib. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01XX33 (WHO) M01AH01 (WHO)
Bioavailability
Unknown
CAS Number
169590-42-5 Y
ChEBI
CHEBI:41423 Y

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Overview

Medical uses

Adverse effects

Mechanism of action

History

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Celecoxib

Nodes106
Edges105
Triples168
Avg. degree1.98
Density0.018868
Components1

How this topic connects Entity context

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Celecoxib

Top relations

related to history · 21
Celecoxib → April, Brigham Young University, BYU, Cir, Co, COX-2, Daniel, Fed, It, John Talley, Monsanto, Monsanto's, Other, Pfizer, Rochester, Searle, Simmons, The, Two, University
has effect · 16
Celecoxib → Anemia, Cardiovascular, Gastrointestinal, GI, Hematologic, Individual, Long-term, Moderate, New-onset, NSAIDs, People, Risk, The, These, Use, When
related to External links · 14
Celecoxib → Archived, Bextra, Celebrex, COX-2 Selective, Drug Administration, FDA, FDA Approves Labeling Supplement, Food, July, June, Non-Selective Non-Steroidal Anti-Inflammatory Drugs, NSAIDs, September, Vioxx
related to Brand names · 12
Celecoxib → Celebrex, December, FDA, In, It, March, May, On, Pfizer, Upon, US, US RE44048
related to Heart attack and stroke · 12
Celecoxib → American Heart Association, As, COX-2, FDA, FDA-mandated, In, In February, Like, NSAIDs, The COX-2, US, Vioxx
related to Structure-activity relationship · 12
Celecoxib → At, COX-1, COX-2, For, Ile523, In, SO2NHCH3, The, The Searle, This, To, Various
related to Anti-inflammatory · 9
Celecoxib → A2, COX-1, COX-2, In, Inhibition, It, Nonselective NSAIDs, NSAIDs, Therefore
related to Drug interactions · 9
Celecoxib → Additionally, Caution, CYP2C9, CYP2D6, CYP3A4, If, SSRI, The, The CYP2C9
has treatment · 8
Celecoxib → Certainly, COX-2, Different, For, However, Karen Seibert, Many, The
Legal status · 7
Celecoxib → AU: S4 (Prescription only) or S3, BR: Class C1 (Other controlled substances), CA: ℞-only, In general: ℞ (Prescription only), NZ: Prescription only, UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

cox-2 risk pfizer drug may use nsaids effects celebrex people searle pain drugs cardiovascular used fda inhibition treatment anti-inflammatory cancer

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Celecoxib3D model (JSmol)Interactive image1.00infobox
CelecoxibAHFS/Drugs.comMonograph1.00infobox
CelecoxibATC codeL01XX33 (WHO) M01AH01 (WHO)1.00infobox
CelecoxibBioavailabilityUnknown1.00infobox
CelecoxibCAS Number169590-42-5 Y1.00infobox
CelecoxibChEBICHEBI:41423 Y1.00infobox
CelecoxibChEMBLChEMBL118 Y1.00infobox
CelecoxibChemSpider2562 Y1.00infobox
CelecoxibCompTox Dashboard (EPA)DTXSID00227771.00infobox
CelecoxibDrug classCyclooxygenase-2 (COX-2) inhibitor1.00infobox
CelecoxibDrugBankDB00482 Y1.00infobox
CelecoxibECHA InfoCard100.211.6441.00infobox
CelecoxibElimination half-life7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)1.00infobox
CelecoxibExcretionFaeces (57%), urine (27%)1.00infobox
CelecoxibFormulaC17H14F3N3O2S1.00infobox
CelecoxibIUPHAR/BPS28921.00infobox
CelecoxibKEGGD00567 Y1.00infobox
CelecoxibLegal statusAU: S4 (Prescription only) or S31.00infobox
CelecoxibLegal statusBR: Class C1 (Other controlled substances)1.00infobox
CelecoxibLegal statusCA: ℞-only1.00infobox
CelecoxibLegal statusNZ: Prescription only1.00infobox
CelecoxibLegal statusUK: POM (Prescription only)1.00infobox
CelecoxibLegal statusUS: ℞-only1.00infobox
CelecoxibLegal statusIn general: ℞ (Prescription only)1.00infobox
CelecoxibLicense dataUS DailyMed: Celecoxib1.00infobox
CelecoxibMedlinePlusa6990221.00infobox
CelecoxibMetabolismLiver (mainly CYP2C9)1.00infobox
CelecoxibMolar mass381.37 g·mol−11.00infobox
CelecoxibPDB ligandCEL (PDBe, RCSB PDB)1.00infobox
CelecoxibPregnancy categoryAU: B31.00infobox

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