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Dihydrofolate reductase: Applications, Research, Regions & Products

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in one-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q14.1 region of chromosome 5.

Language: English [EN]
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Dihydrofolate reductase topic overview

The analysis highlights Applications, Research, Regions and Products as prominent areas in the source structure around Dihydrofolate reductase.

Related topics
66
Source areas
8
Connected nodes
74
Extracted relationships
120
Concept neighborhoods
23
Bridge connections
74

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 15 topics
Therapeutic applications · 14 topics
Function · 10 topics
As a research tool · 9 topics
Structure · 9 topics
Clinical significance · 5 topics
Interactions · 2 topics
Mechanism · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.5.1.3
↗
Aliases
DHFR, DHFRP1, DYR, dihydrofolate reductase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U,…
Band
5q14.1 · 13 C3|13 47.64 cM
Bgee
buccal mucosa cell · ventricular zone · ganglionic eminence · trabecular bone · bone marrow
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Mechanism

Clinical significance

Therapeutic applications

As a research tool

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dihydrofolate reductase connects Entity context

The extracted context around Dihydrofolate reductase shows recurring relationship patterns in the source. For example, Dihydrofolate reductase → axon regeneration, cellular component, cytoplasm, cytosol, dihydrofolate metabolic process, dihydrofolate reductase activity, folate reductase activity, folic acid binding, folic acid metabolic process, methotrexate binding, mitochondrion, mRNA binding, NADP binding, NADPH binding, negative regulation of translation, one-carbon metabolic process, oxidoreductase activity, positive regulation of nitric-oxide synthase activity, regulation of removal of superoxide radicals, regulation of transcription involved in G1/S transition of mitotic cell cycle Another extracted example is Dihydrofolate reductase → abdominal wall, bone marrow, bone marrow cell, buccal mucosa cell, efferent ductule, endothelial cell, epiblast, ganglionic eminence, Gonadal ridge, human fetus, inferior ganglion of vagus nerve, jejunal mucosa, mandibular prominence, maxillary prominence, oocyte, Paneth cell, primitive streak, somite, trabecular bone, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dihydrofolate reductase

Top relations

Gene ontology · 27
Dihydrofolate reductase → axon regeneration, cellular component, cytoplasm, cytosol, dihydrofolate metabolic process, dihydrofolate reductase activity, folate reductase activity, folic acid binding, folic acid metabolic process, methotrexate binding, mitochondrion, mRNA binding, NADP binding, NADPH binding, negative regulation of translation, one-carbon metabolic process, oxidoreductase activity, positive regulation of nitric-oxide synthase activity, regulation of removal of superoxide radicals, regulation of transcription involved in G1/S transition of mitotic cell cycle
Bgee · 20
Dihydrofolate reductase → abdominal wall, bone marrow, bone marrow cell, buccal mucosa cell, efferent ductule, endothelial cell, epiblast, ganglionic eminence, Gonadal ridge, human fetus, inferior ganglion of vagus nerve, jejunal mucosa, mandibular prominence, maxillary prominence, oocyte, Paneth cell, primitive streak, somite, trabecular bone, ventricular zone
RNA expression pattern · 20
Dihydrofolate reductase → abdominal wall, bone marrow, bone marrow cell, buccal mucosa cell, efferent ductule, endothelial cell, epiblast, ganglionic eminence, Gonadal ridge, human fetus, inferior ganglion of vagus nerve, jejunal mucosa, mandibular prominence, maxillary prominence, oocyte, Paneth cell, primitive streak, somite, trabecular bone, ventricular zone
related to External links · 7
Dihydrofolate reductase → Dihydrofolate, MedicineProteopedia, Nobel, P00374, PDB, PDBe-KB, UniProt
related to Function · 5
Dihydrofolate reductase → DHFR, Dihydrofolate, Reaction, Tetrahydrofolate, While
related to Interactions · 3
Dihydrofolate reductase → Dihydrofolate, GroEL, Mdm2
Band · 2
Dihydrofolate reductase → 13 C3|13 47.64 cM, 5q14.1
Chr. · 2
Dihydrofolate reductase → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Dihydrofolate reductase → 80,654,983 bp, 92,525,561 bp
related to Clinical significance · 2
Dihydrofolate reductase → DHFR, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dhfr dihydrofolate nadph tetrahydrofolate enzyme site reductase binding active gene substrate transfer chromosome bp met20 trimethoprim r67 chr human band

Dihydrofolate reductase relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around Dihydrofolate reductase. Examples in this analysis include Dihydrofolate reductase → 1.5.1.3 → ↗ and Dihydrofolate reductase → Aliases → DHFR, DHFRP1, DYR, dihydrofolate reductase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dihydrofolate reductase1.5.1.3↗1.00infobox
Dihydrofolate reductaseAliasesDHFR, DHFRP1, DYR, dihydrofolate reductase1.00infobox
Dihydrofolate reductaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U,…1.00infobox
Dihydrofolate reductaseBand5q14.11.00infobox
Dihydrofolate reductaseBand13 C3|13 47.64 cM1.00infobox
Dihydrofolate reductaseBgeebuccal mucosa cell1.00infobox
Dihydrofolate reductaseBgeeventricular zone1.00infobox
Dihydrofolate reductaseBgeeganglionic eminence1.00infobox
Dihydrofolate reductaseBgeetrabecular bone1.00infobox
Dihydrofolate reductaseBgeebone marrow1.00infobox
Dihydrofolate reductaseBgeebone marrow cell1.00infobox
Dihydrofolate reductaseBgeeoocyte1.00infobox
Dihydrofolate reductaseBgeeinferior ganglion of vagus nerve1.00infobox
Dihydrofolate reductaseBgeejejunal mucosa1.00infobox
Dihydrofolate reductaseBgeeendothelial cell1.00infobox
Dihydrofolate reductaseBgeeabdominal wall1.00infobox
Dihydrofolate reductaseBgeeprimitive streak1.00infobox
Dihydrofolate reductaseBgeehuman fetus1.00infobox
Dihydrofolate reductaseBgeemandibular prominence1.00infobox
Dihydrofolate reductaseBgeemaxillary prominence1.00infobox
Dihydrofolate reductaseBgeeepiblast1.00infobox
Dihydrofolate reductaseBgeeGonadal ridge1.00infobox
Dihydrofolate reductaseBgeeefferent ductule1.00infobox
Dihydrofolate reductaseBgeePaneth cell1.00infobox
Dihydrofolate reductaseBgeesomite1.00infobox
Dihydrofolate reductaseBioGPSn/a1.00infobox
Dihydrofolate reductaseChr.Chromosome 5 (human)1.00infobox
Dihydrofolate reductaseChr.Chromosome 13 (mouse)1.00infobox
Dihydrofolate reductaseDatabasesNCBI: entry; OMA: entry1.00infobox
Dihydrofolate reductaseEnd80,654,983 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dihydrofolate reductase bring nearby vocabulary together. In this analysis, examples include Reductase, Nadph and Tetrahydrofolate. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dihydrofolate reductase
    • Reductase
    • Nadph
    • Tetrahydrofolate
    • Binding
    • Chromosome
    • Gene
    • Transfer
    • Dhfr
    • Enzyme
    • Acid
    • Folate
    • Human
  • dihydrofolate reductase
    • Reductase
    • Nadph
    • Chromosome
    • Gene
    • Tetrahydrofolate
    • Binding
    • Folate
    • Human
    • Bp
    • Chr
    • Transfer
    • R67
  • nadph
    • Tetrahydrofolate
    • Transfer
    • Binding
    • Product
    • Hydride
    • Catalytic
    • Protonation
    • Substrate
    • Reductase
    • Site
    • Band
    • Folate
  • dihydrofolate
    • Reductase
    • Nadph
    • Tetrahydrofolate
    • Binding
    • Chromosome
    • Gene
    • Transfer
    • Dhfr
    • Enzyme
    • Acid
    • Folate
    • Human
  • tetrahydrofolate
    • Cell
    • Synthesis
    • Product
    • Transfer
    • Band
    • Folate
    • Found
    • Human
    • Bp
    • Cancer
    • Chr
    • Methotrexate
  • dihydrofolate reductase deficiency
    • Reductase
    • Nadph
    • Chromosome
    • Gene
    • Tetrahydrofolate
    • Binding
    • Folate
    • Human
    • Bp
    • Chr
    • Transfer
    • R67
  • enzyme
    • Site
    • Binding
    • Substrate
    • Active
    • Nadph
    • Mechanism
    • R67
    • Gene
    • Transfer
    • Reductase
    • Human
    • Bp
  • dihydrofolic acid
    • Folate
    • Synthesis
    • Reductase
    • Tetrahydrofolate
    • Band
    • Human
    • Nadph
    • Bp
    • Cell
    • Chr
    • Methotrexate
    • Used

Connections between topic areas Semantic bridges

For Dihydrofolate reductase, one of the stronger structural bridges in this analysis connects Dihydrofolate reductase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dihydrofolate reductase — Overview · splits 59 ⟂ 16
Dihydrofolate reductase — Therapeutic applications · splits 60 ⟂ 15
Dihydrofolate reductase — Function · splits 64 ⟂ 11
Dihydrofolate reductase — Structure · splits 65 ⟂ 10
Dihydrofolate reductase — As a research tool · splits 65 ⟂ 10
Dihydrofolate reductase — Clinical significance · splits 69 ⟂ 6
Dihydrofolate reductase — Mechanism · splits 72 ⟂ 3
Dihydrofolate reductase — Interactions · splits 72 ⟂ 3

Map overview Semantic statistics

Dihydrofolate reductase

Nodes75
Edges74
Triples120
Avg. degree1.97
Density0.026667
Components1

Source & methodology

TTTA analyzes the structure around Dihydrofolate reductase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Research, Regions & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dihydrofolate reductase · EN edition · Analysis: TopicsToTalkAbout

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