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MAPK8

Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

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2.7.11.24
Aliases
MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK,…
Band
10q11.22 · 14|14 B
Bgee
ganglionic eminence · tendon of biceps brachii · Achilles tendon · stromal cell of endometrium · buccal mucosa cell
BioGPS
More reference expression data

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MAPK8

Nodes38
Edges37
Triples147
Avg. degree1.95
Density0.052632
Components1

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MAPK8

Top relations

Gene ontology · 55
MAPK8 → ATP binding, axon, basal dendrite, cellular response to amino acid starvation, cellular response to cadmium ion, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to organic substance, cellular response to reactive oxygen species, cytoplasm, cytosol, enzyme binding, Fc-epsilon receptor signaling pathway, histone deacetylase binding, histone deacetylase regulator activity, intracellular signal transduction, JNK cascade, JUN kinase activity, JUN phosphorylation
Bgee · 19
MAPK8 → Achilles tendon, barrel cortex, buccal mucosa cell, epithelium of colon, gallbladder, ganglionic eminence, genital tubercle, internal globus pallidus, islet of Langerhans, perirhinal cortex, piriform cortex, primary oocyte, secondary oocyte, stromal cell of endometrium, superior cervical ganglion, tendon of biceps brachii, ventricular zone, visual cortex, zygote
RNA expression pattern · 19
MAPK8 → Achilles tendon, barrel cortex, buccal mucosa cell, epithelium of colon, gallbladder, ganglionic eminence, genital tubercle, internal globus pallidus, islet of Langerhans, perirhinal cortex, piriform cortex, primary oocyte, secondary oocyte, stromal cell of endometrium, superior cervical ganglion, tendon of biceps brachii, ventricular zone, visual cortex, zygote
related to Interactions · 16
MAPK8 → Activating, C-jun, CRK, DUSP1, DUSP10, GSTP1, IRS1, ITCH, MAP2K4, MAP2K7, MAP3K1MAP3K2, MAPK8IP1, MAPK8IP3, Myc, REL, SH3BP5
related to Function · 9
MAPK8 → Four, JNK, MAP, Studies, The, This, TNF-alpha, TNF-alpha-induced, UV
Band · 2
MAPK8 → 10q11.22, 14|14 B
Chr. · 2
MAPK8 → Chromosome 10 (human), Chromosome 14 (mouse)
End · 2
MAPK8 → 33,169,115 bp, 48,439,360 bp
2.7.11.24 · 1
MAPK8 → ↗
Aliases · 1
MAPK8 → MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8

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Important terminology

kinase gene bp chr human band protein chromosome 10 enzyme mouse cell map transcription location jnk apoptosis involved factor mitogen-activated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAPK82.7.11.241.00infobox
MAPK8AliasesMAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 81.00infobox
MAPK8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK,…1.00infobox
MAPK8Band10q11.221.00infobox
MAPK8Band14|14 B1.00infobox
MAPK8Bgeeganglionic eminence1.00infobox
MAPK8Bgeetendon of biceps brachii1.00infobox
MAPK8BgeeAchilles tendon1.00infobox
MAPK8Bgeestromal cell of endometrium1.00infobox
MAPK8Bgeebuccal mucosa cell1.00infobox
MAPK8Bgeeventricular zone1.00infobox
MAPK8Bgeeislet of Langerhans1.00infobox
MAPK8Bgeeinternal globus pallidus1.00infobox
MAPK8Bgeegallbladder1.00infobox
MAPK8Bgeeepithelium of colon1.00infobox
MAPK8Bgeezygote1.00infobox
MAPK8Bgeesecondary oocyte1.00infobox
MAPK8Bgeeprimary oocyte1.00infobox
MAPK8Bgeebarrel cortex1.00infobox
MAPK8Bgeesuperior cervical ganglion1.00infobox
MAPK8Bgeeperirhinal cortex1.00infobox
MAPK8Bgeevisual cortex1.00infobox
MAPK8Bgeegenital tubercle1.00infobox
MAPK8Bgeepiriform cortex1.00infobox
MAPK8BioGPSMore reference expression data1.00infobox
MAPK8Chr.Chromosome 10 (human)1.00infobox
MAPK8Chr.Chromosome 14 (mouse)1.00infobox
MAPK8DatabasesNCBI: entry; OMA: entry1.00infobox
MAPK8End48,439,360 bp1.00infobox
MAPK8End33,169,115 bp1.00infobox

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