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Bcl-2: Applications, Role in disease & Targeted therapies

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first apoptosis regulator identified in any organism.

Language: English [EN]
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Bcl-2 topic overview

The analysis highlights Applications, Role in disease and Targeted therapies as prominent areas in the source structure around Bcl-2.

Related topics
106
Source areas
7
Connected nodes
113
Extracted relationships
374
Concept neighborhoods
23
Bridge connections
113

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 27 topics
Targeted therapies · 25 topics
Role in disease · 21 topics
Overview · 17 topics
Diagnostic use · 6 topics
Function · 5 topics
Isoforms · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Band
18q21.33 · 1 E2.1|1 49.76 cM
Bgee
dorsal motor nucleus of vagus nerve · superficial temporal artery · Achilles tendon · epithelium of colon · inferior olivary nucleus
BioGPS
More reference expression data
Chr.
Chromosome 18 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Isoforms

Function

Role in disease

Diagnostic use

Targeted therapies

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Bcl-2 connects Entity context

The extracted context around Bcl-2 shows recurring relationship patterns in the source. For example, Bcl-2 → actin filament organization, animal organ morphogenesis, apoptotic mitochondrial changes, apoptotic process, axon regeneration, axonogenesis, B cell differentiation, B cell homeostasis, B cell lineage commitment, B cell proliferation, B cell receptor signaling pathway, behavioral fear response, BH3 domain binding, branching involved in ureteric bud morphogenesis, CD8-positive, alpha-beta T cell lineage commitment, cell morphogenesis, cell population proliferation, cell-cell adhesion, cellular calcium ion homeostasis, cellular response to DNA damage stimulus Another extracted example is Bcl-2 → BADBAX, BAK1, BCAP31, BCL2-like, BCL2L11, BECN1, BID, BIK, BMF, BNIP2, BNIP3, BNIPL, C-Raf, CAPN2, CASP8, Cdk1, HRK, IRS1, Myc, Noxa. Use these groups to spot repeated connection types before inspecting the individual relationships.

Bcl-2

Top relations

Gene ontology · 172
Bcl-2 → actin filament organization, animal organ morphogenesis, apoptotic mitochondrial changes, apoptotic process, axon regeneration, axonogenesis, B cell differentiation, B cell homeostasis, B cell lineage commitment, B cell proliferation, B cell receptor signaling pathway, behavioral fear response, BH3 domain binding, branching involved in ureteric bud morphogenesis, CD8-positive, alpha-beta T cell lineage commitment, cell morphogenesis, cell population proliferation, cell-cell adhesion, cellular calcium ion homeostasis, cellular response to DNA damage stimulus
related to Interactions · 28
Bcl-2 → BADBAX, BAK1, BCAP31, BCL2-like, BCL2L11, BECN1, BID, BIK, BMF, BNIP2, BNIP3, BNIPL, C-Raf, CAPN2, CASP8, Cdk1, HRK, IRS1, Myc, Noxa
Bgee · 20
Bcl-2 → Achilles tendon, aortic valve, ascending aorta, blood, caput epididymis, ciliary body, dorsal motor nucleus of vagus nerve, epithelium of colon, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, lumbar spinal ganglion, mesenteric lymph nodes, optic nerve, Rostral migratory stream, superficial temporal artery, trigeminal ganglion, vas deferens, vestibular membrane of cochlear duct
RNA expression pattern · 20
Bcl-2 → Achilles tendon, aortic valve, ascending aorta, blood, caput epididymis, ciliary body, dorsal motor nucleus of vagus nerve, epithelium of colon, external globus pallidus, inferior olivary nucleus, internal globus pallidus, iris, lumbar spinal ganglion, mesenteric lymph nodes, optic nerve, Rostral migratory stream, superficial temporal artery, trigeminal ganglion, vas deferens, vestibular membrane of cochlear duct
related to External links · 16
Bcl-2 → Bcl-2 Family, BCL2, Genes, Human Apoptosis, Human BCL2, Medicine Medical Subject Headings, MeSH, National Library, Overview, P10415, PDB, PDBe-KB, Proteins, The Bcl-2 Family DatabaseThe, UCSC Genome Browser, UniProt
related to Venetoclax (ABT-199) · 16
Bcl-2 → Abbvie, ABT-199, April, Bcl-w, Bcl-xL, BH3-mimetic, Clinical, CLL, Dec, Due, FDA, Good, In June, It, This, US FDA
related to ABT-737 and navitoclax (ABT-263) · 15
Bcl-2 → A1, Abbott Laboratories, ABT-263, ABT-737, B-cell, Bcl-w, Bcl-xL, Because, BH3, In, Mcl-1, SCLC, SMI, This, While
related to Function · 10
Bcl-2 → Additionally, Bak, Bax, BCL-2/Xl, BCL-Xl, BH3-only, ROS, The, There, These
related to Auto-immune diseases · 9
Bcl-2 → AICD, Apoptosis, Bim, Due, In, Other, Researchers, The, When
see also · 9
Bcl-2 → ApoptosomeBcl-2, BAK, BAX, Bcl-2-associated, BH3, BID, CaspasesNoxaMicrophthalmia-associated, PUMA, Senolytics

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

apoptosis lymphoma cell bcl2 gene 18 human proteins cancer bp abt-737 protein bcl-xl cells chr band family chromosome venetoclax death

Bcl-2 relationships Subject–Predicate–Object triples

TTTA extracted 374 structured relationships around Bcl-2. Examples in this analysis include Bcl-2 → Aliases → BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2 and Bcl-2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Bcl-2AliasesBCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-21.00infobox
Bcl-2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG1.00infobox
Bcl-2Band18q21.331.00infobox
Bcl-2Band1 E2.1|1 49.76 cM1.00infobox
Bcl-2Bgeedorsal motor nucleus of vagus nerve1.00infobox
Bcl-2Bgeesuperficial temporal artery1.00infobox
Bcl-2BgeeAchilles tendon1.00infobox
Bcl-2Bgeeepithelium of colon1.00infobox
Bcl-2Bgeeinferior olivary nucleus1.00infobox
Bcl-2Bgeeoptic nerve1.00infobox
Bcl-2Bgeetrigeminal ganglion1.00infobox
Bcl-2Bgeeinternal globus pallidus1.00infobox
Bcl-2Bgeeexternal globus pallidus1.00infobox
Bcl-2Bgeecaput epididymis1.00infobox
Bcl-2Bgeeascending aorta1.00infobox
Bcl-2Bgeeaortic valve1.00infobox
Bcl-2BgeeRostral migratory stream1.00infobox
Bcl-2Bgeevestibular membrane of cochlear duct1.00infobox
Bcl-2Bgeeiris1.00infobox
Bcl-2Bgeelumbar spinal ganglion1.00infobox
Bcl-2Bgeemesenteric lymph nodes1.00infobox
Bcl-2Bgeeciliary body1.00infobox
Bcl-2Bgeeblood1.00infobox
Bcl-2Bgeevas deferens1.00infobox
Bcl-2BioGPSMore reference expression data1.00infobox
Bcl-2Chr.Chromosome 18 (human)1.00infobox
Bcl-2Chr.Chromosome 1 (mouse)1.00infobox
Bcl-2DatabasesNCBI: entry; OMA: entry1.00infobox
Bcl-2End63,320,128 bp1.00infobox
Bcl-2End106,642,004 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Bcl-2 bring nearby vocabulary together. In this analysis, examples include Gene, Proteins and Venetoclax. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Bcl-2
    • Gene
    • Proteins
    • Venetoclax
    • Bcl-xl
    • Protein
    • Lymphoma
    • Function
    • Inhibitor
    • Drug
    • Family
    • May
    • Human
  • bcl-2
    • Gene
    • Proteins
    • Venetoclax
    • Bcl-xl
    • Protein
    • Lymphoma
    • Function
    • Inhibitor
    • Drug
    • Family
    • May
    • Human
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • External
    • Genome
    • Band
    • Function
    • Regulator
    • Cancer
    • Lymphoma
  • bcl-2 family
    • Proteins
    • Death
    • Apoptosis
    • Gene
    • Venetoclax
    • Bcl-xl
    • Protein
    • Lymphoma
    • Regulator
    • Function
    • Inhibitor
    • Drug
  • apoptosis
    • Diseases
    • Regulator
    • Role
    • Family
    • Cells
    • Available
    • Immune
    • Death
    • Bcl2
    • Human
    • Cell
    • Bcl-2
  • small cell lung cancer
    • Death
    • Cancer
    • Cell
    • Navitoclax
    • Activity
    • Abt-737
    • Protein
    • Human
    • Gene
    • Lymphoma
    • External
    • Genome
  • cell
    • Death
    • Cancer
    • Activity
    • Protein
    • Human
    • External
    • Genome
    • Band
    • Function
    • Immune
    • Inhibitor
    • Location
  • abt-737
    • B-cell
    • Navitoclax
    • Bcl-xl
    • Cancer
    • External
    • Lymphoma
    • Available
    • Cll
    • Diseases
    • Function
    • Inhibitor
    • Location

Connections between topic areas Semantic bridges

For Bcl-2, one of the stronger structural bridges in this analysis connects Bcl-2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Bcl-2 — Interactions · splits 86 ⟂ 28
Bcl-2 — Targeted therapies · splits 88 ⟂ 26
Bcl-2 — Role in disease · splits 92 ⟂ 22
Bcl-2 — Overview · splits 96 ⟂ 18
Bcl-2 — Diagnostic use · splits 107 ⟂ 7
Bcl-2 — Isoforms · splits 108 ⟂ 6
Bcl-2 — Function · splits 108 ⟂ 6

Map overview Semantic statistics

Bcl-2

Nodes114
Edges113
Triples374
Avg. degree1.98
Density0.017544
Components1

Source & methodology

TTTA analyzes the structure around Bcl-2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Role in disease & Targeted therapies, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Bcl-2 · EN edition · Analysis: TopicsToTalkAbout

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