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CHD8

Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.

Function, Clinical significance & Overview

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Function

1 related topics

Clinical significance

1 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
CHD8, AUTS18, HELSNF1, chromodomain helicase DNA binding protein 8, IDDAM
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CKA, 2DL6
Band
14q11.2 · 14|14 C2
Bgee
sural nerve · ventricular zone · right hemisphere of cerebellum · granulocyte · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 14 (mouse)

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Overview

Function

Clinical significance

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Map overview Semantic statistics

CHD8

Nodes8
Edges7
Triples120
Avg. degree1.75
Density0.25
Components1

How this topic connects Entity context

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CHD8

Top relations

Gene ontology · 40
CHD8 → armadillo repeat domain binding, ATP binding, ATP-dependent activity, acting on DNA, beta-catenin binding, brain development, canonical Wnt signaling pathway, chromatin binding, chromatin organization, digestive tract development, DNA binding, DNA duplex unwinding, DNA helicase activity, helicase activity, histone binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, in utero embryonic development, methylated histone binding, MLL1 complex, negative regulation of apoptotic process
Bgee · 19
CHD8 → anterior pituitary, epithelium of colon, external carotid artery, fossa, ganglionic eminence, genital tubercle, granulocyte, Ileal epithelium, internal carotid artery, right hemisphere of cerebellum, Rostral migratory stream, secondary oocyte, skin of abdomen, skin of leg, spleen, sural nerve, tail of embryo, ventricular zone, zygote
RNA expression pattern · 19
CHD8 → anterior pituitary, epithelium of colon, external carotid artery, fossa, ganglionic eminence, genital tubercle, granulocyte, Ileal epithelium, internal carotid artery, right hemisphere of cerebellum, Rostral migratory stream, secondary oocyte, skin of abdomen, skin of leg, spleen, sural nerve, tail of embryo, ventricular zone, zygote
related to Function · 9
CHD8 → ADP, ATP, CHD8-knockout, DNA, H1, It, Snf2, The, Wnt
related to External links · 8
CHD8 → Chromodomain-helicase-DNA-binding, Human CHD8, Overview, PDB, PDBe-KB, Q9HCK8, UCSC Genome Browser, UniProt
Band · 2
CHD8 → 14q11.2, 14|14 C2
Chr. · 2
CHD8 → Chromosome 14 (human), Chromosome 14 (mouse)
End · 2
CHD8 → 21,456,126 bp, 52,495,237 bp
Aliases · 1
CHD8 → CHD8, AUTS18, HELSNF1, chromodomain helicase DNA binding protein 8, IDDAM
Available structures · 1
CHD8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CKA, 2DL6

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Important terminology

human gene bp protein chr band chromosome helicase 14 location chromatin dna binding external mouse development enzyme function genes asd

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CHD8AliasesCHD8, AUTS18, HELSNF1, chromodomain helicase DNA binding protein 8, IDDAM1.00infobox
CHD8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CKA, 2DL61.00infobox
CHD8Band14q11.21.00infobox
CHD8Band14|14 C21.00infobox
CHD8Bgeesural nerve1.00infobox
CHD8Bgeeventricular zone1.00infobox
CHD8Bgeeright hemisphere of cerebellum1.00infobox
CHD8Bgeegranulocyte1.00infobox
CHD8Bgeeganglionic eminence1.00infobox
CHD8Bgeeskin of leg1.00infobox
CHD8Bgeeskin of abdomen1.00infobox
CHD8Bgeeepithelium of colon1.00infobox
CHD8Bgeeanterior pituitary1.00infobox
CHD8Bgeespleen1.00infobox
CHD8Bgeetail of embryo1.00infobox
CHD8Bgeegenital tubercle1.00infobox
CHD8BgeeRostral migratory stream1.00infobox
CHD8Bgeezygote1.00infobox
CHD8Bgeeinternal carotid artery1.00infobox
CHD8Bgeesecondary oocyte1.00infobox
CHD8Bgeeexternal carotid artery1.00infobox
CHD8Bgeefossa1.00infobox
CHD8BgeeIleal epithelium1.00infobox
CHD8BioGPSMore reference expression data1.00infobox
CHD8Chr.Chromosome 14 (human)1.00infobox
CHD8Chr.Chromosome 14 (mouse)1.00infobox
CHD8DatabasesNCBI: entry; OMA: entry1.00infobox
CHD8End21,456,126 bp1.00infobox
CHD8End52,495,237 bp1.00infobox
CHD8EnsemblENSG000001008881.00infobox

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