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Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.
The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around CHD8.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around CHD8 shows recurring relationship patterns in the source. For example, CHD8 → armadillo repeat domain binding, ATP binding, ATP-dependent activity, acting on DNA, beta-catenin binding, brain development, canonical Wnt signaling pathway, chromatin binding, chromatin organization, digestive tract development, DNA binding, DNA duplex unwinding, DNA helicase activity, helicase activity, histone binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, in utero embryonic development, methylated histone binding, MLL1 complex, negative regulation of apoptotic process Another extracted example is CHD8 → anterior pituitary, epithelium of colon, external carotid artery, fossa, ganglionic eminence, genital tubercle, granulocyte, Ileal epithelium, internal carotid artery, right hemisphere of cerebellum, Rostral migratory stream, secondary oocyte, skin of abdomen, skin of leg, spleen, sural nerve, tail of embryo, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
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human gene bp protein chr band chromosome helicase 14 location chromatin dna binding external mouse development enzyme function genes asd
TTTA extracted 110 structured relationships around CHD8. Examples in this analysis include CHD8 → Aliases → CHD8, AUTS18, HELSNF1, chromodomain helicase DNA binding protein 8, IDDAM and CHD8 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CKA, 2DL6. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CHD8 | Aliases | CHD8, AUTS18, HELSNF1, chromodomain helicase DNA binding protein 8, IDDAM | 1.00 | infobox |
| CHD8 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CKA, 2DL6 | 1.00 | infobox |
| CHD8 | Band | 14q11.2 | 1.00 | infobox |
| CHD8 | Band | 14|14 C2 | 1.00 | infobox |
| CHD8 | Bgee | sural nerve | 1.00 | infobox |
| CHD8 | Bgee | ventricular zone | 1.00 | infobox |
| CHD8 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| CHD8 | Bgee | granulocyte | 1.00 | infobox |
| CHD8 | Bgee | ganglionic eminence | 1.00 | infobox |
| CHD8 | Bgee | skin of leg | 1.00 | infobox |
| CHD8 | Bgee | skin of abdomen | 1.00 | infobox |
| CHD8 | Bgee | epithelium of colon | 1.00 | infobox |
| CHD8 | Bgee | anterior pituitary | 1.00 | infobox |
| CHD8 | Bgee | spleen | 1.00 | infobox |
| CHD8 | Bgee | tail of embryo | 1.00 | infobox |
| CHD8 | Bgee | genital tubercle | 1.00 | infobox |
| CHD8 | Bgee | Rostral migratory stream | 1.00 | infobox |
| CHD8 | Bgee | zygote | 1.00 | infobox |
| CHD8 | Bgee | internal carotid artery | 1.00 | infobox |
| CHD8 | Bgee | secondary oocyte | 1.00 | infobox |
| CHD8 | Bgee | external carotid artery | 1.00 | infobox |
| CHD8 | Bgee | fossa | 1.00 | infobox |
| CHD8 | Bgee | Ileal epithelium | 1.00 | infobox |
| CHD8 | BioGPS | More reference expression data | 1.00 | infobox |
| CHD8 | Chr. | Chromosome 14 (human) | 1.00 | infobox |
| CHD8 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| CHD8 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CHD8 | End | 21,456,126 bp | 1.00 | infobox |
| CHD8 | End | 52,495,237 bp | 1.00 | infobox |
| CHD8 | Ensembl | ENSG00000100888 | 1.00 | infobox |
The concept neighborhoods around CHD8 bring nearby vocabulary together. In this analysis, examples include Human, Genes and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CHD8, one of the stronger structural bridges in this analysis connects CHD8 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CHD8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CHD8 · EN edition · Analysis: TopicsToTalkAbout
