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SUMO protein

In molecular biology, SUMO (Small Ubiquitin-like MOdifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. This process is called SUMOylation (pronounced soo-muh-lā-shun and sometimes written sumoylation). SUMOylation is a post-translational modification involved…

Function, Role in Human Pathology & Overview

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Overview

Function

Structure

Prediction of SUMO attachment

SUMO attachment (SUMOylation)

DeSUMOylation

Role in Human Pathology

Role in protein purification

Advanced semantic analysis

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Map overview Semantic statistics

SUMO protein

Nodes88
Edges87
Triples89
Avg. degree1.98
Density0.022727
Components1

How this topic connects Entity context

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SUMO protein

Top relations

related to Function · 26
SUMO protein → Among, As, At, During, GeneRIFs, Glutamine, II, In, One, Proline, RanGAP1, Serine, SUMO, SUMO-1, SUMO-2, SUMO-2/3, SUMO-3, SUMO-4, SUMO1, SUMO2
related to Role in Human Pathology · 24
SUMO protein → Beyond, DNA, DNA-binding, EMT, Here, HIF-1α, Hippel-Lindau, In, IκB, Li-Fraumeni, MDM2, MMPs, Mouse Double Minute, NF-κB, One, RING, SMT3IP1/SENP3, SUMO, SUMOylated, SUMOylation
related to DeSUMOylation · 10
SUMO protein → As, In, SENP, SMT3, Specific, SUMO, SUMO E3, This, Ulp1, Ulp2
related to Structure · 8
SUMO protein → Although SUMO, It, N-terminal, NMR, SUMO, SUMO1, The, This N-terminal
related to DNA damage response · 7
SUMO protein → Also, Cellular DNA, DDR, DNA, SUMO, SUMOylation, When DNA
related to External links · 7
SUMO protein → ExPASy, HomoloGene, Programs, SUMO, SUMO1, SUMO1 SUMO2 SUMO3 SUMO4, SUMOylation

Important terminology Word statistics

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Important terminology

sumo proteins sumoylation protein human ubiquitin amino may target yeast sites one protease modification cell dna shown p53 family sumo-1

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NEDD 8instance ofas it is for the other ubiquitin-like proteins0.80text
Cdc48 may then dissociate the SUMOylatedinstance ofsegregases0.80text
ubiquitinated target from its bound proteininstance ofsegregases0.80text
yeast lies in their potential to inform scientists in the researchinstance ofThis may be beneficial in some circumstances as it supports the breakdown of accumulated waste products.The importance of these studies in models0.80text
development of precise biomedical interventions that can translate to the improvement of human health in an array of clinical aspectsinstance ofThis may be beneficial in some circumstances as it supports the breakdown of accumulated waste products.The importance of these studies in models0.80text
SUMO or MBPinstance ofIn order to purify such proteins it may be necessary to fuse the protein of interest with a solubility tag0.80text
Ulp1 peptidaseinstance ofSUMO can later be cleaved from the protein of interest using a SUMO-specific protease0.80text
SUMO proteinrelated to DeSUMOylationSUMO0.60section
SUMO proteinrelated to DeSUMOylationSpecific0.60section
SUMO proteinrelated to DeSUMOylationSENP0.60section
SUMO proteinrelated to DeSUMOylationUlp10.60section
SUMO proteinrelated to DeSUMOylationUlp20.60section

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