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Venlafaxine

Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. Studies have shown that venlafaxine improves post-traumatic stress disorder…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AX16 (WHO)
Bioavailability
42±15%
CAS Number
93413-69-5 Y · as HCl: 99300-78-4
ChEBI
CHEBI:9943 Y · as HCl: CHEBI:9944

Topics to explore

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Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Chemistry

Society and culture

Veterinary uses

Advanced semantic analysis

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Map overview Semantic statistics

Venlafaxine

Nodes166
Edges165
Triples179
Avg. degree1.99
Density0.012048
Components1

How this topic connects Entity context

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Venlafaxine

Top relations

related to Pharmacokinetics · 23
Venlafaxine → ABCB1, At, C-carriers, CC, CT, CYP2D6, East Asians, Europeans, Even, II, It, No, O-desmethylvenlafaxine, P-glycoprotein, P-gp, Pristiq, Side, SNP, SNRI, Steady-state
related to Overdose · 13
Venlafaxine → Administration, Effexor, Effexor XR, Forced, Healthcare, It, Monitoring, Most, Plasma, Published, Seizures, SSRI, There
related to Chemistry · 11
Venlafaxine → C17H27NO2, C17H28ClNO2, It, MAOIs, R/S, RIMAs, SSRIs, Studies, The, The IUPAC, This
related to Serotonin syndrome · 11
Venlafaxine → An, DMT, DXM, LSD/LSA, MAOIs, MDMA, Serotonin, SNRIs, SSRIs, The, Venlafaxine-induced
related to Miscarriage · 10
Venlafaxine → According, As, Canadian Medical Association Journal, May, National Birth Defects Prevention, NHS, Prospective, SRIs, Study, There
related to Post-SSRI sexual dysfunction · 7
Venlafaxine → Characteristic, HT1A, Post-SSRI, PSSD, SNRIs, The, The DSM-5
Legal status · 6
Venlafaxine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Pharmacodynamics · 6
Venlafaxine → Additionally, It, NET, SNDRI, SNRI, The
related to Bipolar disorder · 5
Venlafaxine → According, Because, II, ISBD Task Force, SSRIs
related to Brand names · 5
Venlafaxine → Effexor, In, Pfizer, Upjohn, Viatris

Important terminology Word statistics

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Important terminology

serotonin risk treatment may effects depression patients also symptoms dysfunction sexual reuptake disorder use side suicide antidepressant syndrome study studies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Venlafaxine3D model (JSmol)Interactive image1.00infobox
VenlafaxineAHFS/Drugs.comMonograph1.00infobox
VenlafaxineATC codeN06AX16 (WHO)1.00infobox
VenlafaxineBioavailability42±15%1.00infobox
VenlafaxineCAS Number93413-69-5 Y1.00infobox
VenlafaxineCAS Numberas HCl: 99300-78-41.00infobox
VenlafaxineChEBICHEBI:9943 Y1.00infobox
VenlafaxineChEBIas HCl: CHEBI:99441.00infobox
VenlafaxineChEMBLChEMBL637 Y1.00infobox
VenlafaxineChEMBLas HCl: ChEMBL12010661.00infobox
VenlafaxineChemSpider5454 Y1.00infobox
VenlafaxineChemSpideras HCl: 566411.00infobox
VenlafaxineChiralityRacemic mixture1.00infobox
VenlafaxineCompTox Dashboard (EPA)DTXSID60237371.00infobox
VenlafaxineDrug classSerotonin–norepinephrine reuptake inhibitor1.00infobox
VenlafaxineDrugBankDB00285 Y1.00infobox
VenlafaxineDrugBankas HCl: DBSALT0001861.00infobox
VenlafaxineECHA InfoCard100.122.4181.00infobox
VenlafaxineElimination half-life5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended-release preparations), 11±2 h (active metabolite)1.00infobox
VenlafaxineExcretionKidney (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites)1.00infobox
VenlafaxineFormulaC17H27NO21.00infobox
VenlafaxineKEGGD08670 Y1.00infobox
VenlafaxineKEGGas HCl: D008211.00infobox
VenlafaxineLegal statusAU: S4 (Prescription only)1.00infobox
VenlafaxineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
VenlafaxineLegal statusCA: ℞-only1.00infobox
VenlafaxineLegal statusUK: POM (Prescription only)1.00infobox
VenlafaxineLegal statusUS: ℞-only1.00infobox
VenlafaxineLegal statusEU: Rx-only1.00infobox
VenlafaxineLicense dataUS DailyMed: Venlafaxine1.00infobox

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