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CYP2E1

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign…

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1.14.14.1
↗
Aliases
CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
Band
10q26.3 · 7 F4|7 85.94 cM
Bgee
right lobe of liver · right hemisphere of cerebellum · body of pancreas · right frontal lobe · right uterine tube
BioGPS
More reference expression data

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CYP2E1

Nodes83
Edges82
Triples142
Avg. degree1.98
Density0.024096
Components1

How this topic connects Entity context

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CYP2E1

Top relations

Gene ontology · 39
CYP2E1 → arachidonic acid epoxygenase activity, benzene metabolic process, carbon tetrachloride metabolic process, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, Golgi membrane, halogenated hydrocarbon metabolic process, heme binding, heterocycle metabolic process, Hsp70 protein binding, Hsp90 protein binding, intracellular membrane-bounded organelle, intrinsic component of endoplasmic reticulum membrane, iron ion binding, long-chain fatty acid biosynthetic process, membrane, metal ion binding
Bgee · 20
CYP2E1 → ankle joint, body of pancreas, Brodmann area 9, endothelial cell, human kidney, intercostal muscle, lactiferous gland, left lobe of liver, middle temporal gyrus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right uterine tube, skin of abdomen, skin of leg, subcutaneous adipose tissue, tunica adventitia of aorta, tunica media of zone of aorta, white adipose tissue
RNA expression pattern · 20
CYP2E1 → ankle joint, body of pancreas, Brodmann area 9, endothelial cell, human kidney, intercostal muscle, lactiferous gland, left lobe of liver, middle temporal gyrus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right uterine tube, skin of abdomen, skin of leg, subcutaneous adipose tissue, tunica adventitia of aorta, tunica media of zone of aorta, white adipose tissue
related to Disease relevance · 6
CYP2E1 → DNA, In, NAPQI, P450, ROS, The
related to Structure · 6
CYP2E1 → Its, L368, Like, P450, T303, The
related to Function · 3
CYP2E1 → P450, The, While
related to Genetic regulation · 3
CYP2E1 → For, In, The
Band · 2
CYP2E1 → 10q26.3, 7 F4|7 85.94 cM
Chr. · 2
CYP2E1 → Chromosome 10 (human), Chromosome 7 (mouse)
End · 2
CYP2E1 → 133,561,220 bp, 140,354,900 bp

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Important terminology

enzyme ethanol enzymes human p450 substrates cytochrome may acid body active including bp gene also fatty chr band levels site

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CYP2E11.14.14.1↗1.00infobox
CYP2E1AliasesCYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 11.00infobox
CYP2E1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z1.00infobox
CYP2E1Band10q26.31.00infobox
CYP2E1Band7 F4|7 85.94 cM1.00infobox
CYP2E1Bgeeright lobe of liver1.00infobox
CYP2E1Bgeeright hemisphere of cerebellum1.00infobox
CYP2E1Bgeebody of pancreas1.00infobox
CYP2E1Bgeeright frontal lobe1.00infobox
CYP2E1Bgeeright uterine tube1.00infobox
CYP2E1Bgeeskin of leg1.00infobox
CYP2E1Bgeeskin of abdomen1.00infobox
CYP2E1Bgeeendothelial cell1.00infobox
CYP2E1Bgeemiddle temporal gyrus1.00infobox
CYP2E1BgeeBrodmann area 91.00infobox
CYP2E1Bgeeleft lobe of liver1.00infobox
CYP2E1Bgeetunica adventitia of aorta1.00infobox
CYP2E1Bgeewhite adipose tissue1.00infobox
CYP2E1Bgeeright kidney1.00infobox
CYP2E1Bgeelactiferous gland1.00infobox
CYP2E1Bgeesubcutaneous adipose tissue1.00infobox
CYP2E1Bgeeintercostal muscle1.00infobox
CYP2E1Bgeehuman kidney1.00infobox
CYP2E1Bgeeankle joint1.00infobox
CYP2E1Bgeetunica media of zone of aorta1.00infobox
CYP2E1BioGPSMore reference expression data1.00infobox
CYP2E1Chr.Chromosome 10 (human)1.00infobox
CYP2E1Chr.Chromosome 7 (mouse)1.00infobox
CYP2E1DatabasesNCBI: entry; OMA: entry1.00infobox
CYP2E1End133,561,220 bp1.00infobox

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