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CYP2E1: Applications, Function & Regulation
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign…
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CYP2E1 topic overview
The analysis highlights Applications, Function and Regulation as prominent areas in the source structure around CYP2E1.
Related topics
76
Source areas
6
Connected nodes
82
Extracted relationships
142
Concept neighborhoods
23
Bridge connections
82
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 36 topics
Regulation · 15 topics
Disease relevance · 10 topics
Structure · 8 topics
Overview · 5 topics
Applications · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
1.14.14.1
↗
Aliases
CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
Band
10q26.3 · 7 F4|7 85.94 cM
Bgee
right lobe of liver · right hemisphere of cerebellum · body of pancreas · right frontal lobe · right uterine tube
BioGPS
More reference expression data
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How CYP2E1 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around CYP2E1 shows recurring relationship patterns in the source. For example, CYP2E1 → arachidonic acid epoxygenase activity, benzene metabolic process, carbon tetrachloride metabolic process, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, Golgi membrane, halogenated hydrocarbon metabolic process, heme binding, heterocycle metabolic process, Hsp70 protein binding, Hsp90 protein binding, intracellular membrane-bounded organelle, intrinsic component of endoplasmic reticulum membrane, iron ion binding, long-chain fatty acid biosynthetic process, membrane, metal ion binding Another extracted example is CYP2E1 → ankle joint, body of pancreas, Brodmann area 9, endothelial cell, human kidney, intercostal muscle, lactiferous gland, left lobe of liver, middle temporal gyrus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right uterine tube, skin of abdomen, skin of leg, subcutaneous adipose tissue, tunica adventitia of aorta, tunica media of zone of aorta, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.
CYP2E1
Top relations
Gene ontology· 39
CYP2E1 → arachidonic acid epoxygenase activity, benzene metabolic process, carbon tetrachloride metabolic process, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, Golgi membrane, halogenated hydrocarbon metabolic process, heme binding, heterocycle metabolic process, Hsp70 protein binding, Hsp90 protein binding, intracellular membrane-bounded organelle, intrinsic component of endoplasmic reticulum membrane, iron ion binding, long-chain fatty acid biosynthetic process, membrane, metal ion binding
Bgee· 20
CYP2E1 → ankle joint, body of pancreas, Brodmann area 9, endothelial cell, human kidney, intercostal muscle, lactiferous gland, left lobe of liver, middle temporal gyrus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right uterine tube, skin of abdomen, skin of leg, subcutaneous adipose tissue, tunica adventitia of aorta, tunica media of zone of aorta, white adipose tissue
RNA expression pattern· 20
CYP2E1 → ankle joint, body of pancreas, Brodmann area 9, endothelial cell, human kidney, intercostal muscle, lactiferous gland, left lobe of liver, middle temporal gyrus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right uterine tube, skin of abdomen, skin of leg, subcutaneous adipose tissue, tunica adventitia of aorta, tunica media of zone of aorta, white adipose tissue
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 142 structured relationships around CYP2E1. Examples in this analysis include CYP2E1 → 1.14.14.1 → ↗ and CYP2E1 → Aliases → CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
CYP2E1
1.14.14.1
↗
1.00
infobox
CYP2E1
Aliases
CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
1.00
infobox
CYP2E1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
1.00
infobox
CYP2E1
Band
10q26.3
1.00
infobox
CYP2E1
Band
7 F4|7 85.94 cM
1.00
infobox
CYP2E1
Bgee
right lobe of liver
1.00
infobox
CYP2E1
Bgee
right hemisphere of cerebellum
1.00
infobox
CYP2E1
Bgee
body of pancreas
1.00
infobox
CYP2E1
Bgee
right frontal lobe
1.00
infobox
CYP2E1
Bgee
right uterine tube
1.00
infobox
CYP2E1
Bgee
skin of leg
1.00
infobox
CYP2E1
Bgee
skin of abdomen
1.00
infobox
CYP2E1
Bgee
endothelial cell
1.00
infobox
CYP2E1
Bgee
middle temporal gyrus
1.00
infobox
CYP2E1
Bgee
Brodmann area 9
1.00
infobox
CYP2E1
Bgee
left lobe of liver
1.00
infobox
CYP2E1
Bgee
tunica adventitia of aorta
1.00
infobox
CYP2E1
Bgee
white adipose tissue
1.00
infobox
CYP2E1
Bgee
right kidney
1.00
infobox
CYP2E1
Bgee
lactiferous gland
1.00
infobox
CYP2E1
Bgee
subcutaneous adipose tissue
1.00
infobox
CYP2E1
Bgee
intercostal muscle
1.00
infobox
CYP2E1
Bgee
human kidney
1.00
infobox
CYP2E1
Bgee
ankle joint
1.00
infobox
CYP2E1
Bgee
tunica media of zone of aorta
1.00
infobox
CYP2E1
BioGPS
More reference expression data
1.00
infobox
CYP2E1
Chr.
Chromosome 10 (human)
1.00
infobox
CYP2E1
Chr.
Chromosome 7 (mouse)
1.00
infobox
CYP2E1
Databases
NCBI: entry; OMA: entry
1.00
infobox
CYP2E1
End
133,561,220 bp
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around CYP2E1 bring nearby vocabulary together. In this analysis, examples include Enzyme, P450 and Body. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
CYP2E1
Enzyme
P450
Body
Cytochrome
Enzymes
Ethanol
Human
Expression
Gene
Levels
Liver
Including
cyp2e1
Enzyme
P450
Body
Cytochrome
Enzymes
Ethanol
Human
Expression
Gene
Levels
Liver
Including
cytochrome p450
P450
Human
Location
Gene
Function
Metabolism
Enzymes
Site
Chromosome
Iron
Protein
Active
arachidonic acid
Fatty
Function
Metabolic
Many
Also
Body
Cyp2e1
Benzene
Heme
Metabolism
Band
Chromosome
20-hydroxyeicosatetraenoic acid
Fatty
Function
Metabolic
Many
Also
Body
Cyp2e1
Benzene
Heme
Metabolism
Band
Chromosome
docosahexaenoic acid
Fatty
Function
Metabolic
Many
Also
Body
Cyp2e1
Benzene
Heme
Metabolism
Band
Chromosome
eicosapentaenoic acid
Fatty
Function
Metabolic
Many
Also
Body
Cyp2e1
Benzene
Heme
Metabolism
Band
Chromosome
epoxydocosapentaenoic acid
Fatty
Function
Metabolic
Many
Also
Body
Cyp2e1
Benzene
Heme
Metabolism
Band
Chromosome
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For CYP2E1, one of the stronger structural bridges in this analysis connects CYP2E1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
CYP2E1
Nodes83
Edges82
Triples142
Avg. degree1.98
Density0.024096
Components1
Source & methodology
TTTA analyzes the structure around CYP2E1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Function & Regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
