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Orphenadrine: History & Applications

Orphenadrine is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine. It is a muscle relaxant that is used to treat muscle pain and to help with motor control in Parkinson's disease, but has largely been superseded by newer drugs.[citation needed] It is considered a dirty drug due to its multiple…

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Orphenadrine topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Orphenadrine.

Related topics
46
Source areas
7
Connected nodes
53
Extracted relationships
66
Concept neighborhoods
16
Bridge connections
53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 12 topics
Overview · 8 topics
Side effects · 7 topics
Chemistry · 6 topics
Formulation · 5 topics
History · 4 topics
Medical uses · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M03BC01 (WHO) N04AB02 (WHO)
Bioavailability
90%
CAS Number
83-98-7 Y
ChEBI
CHEBI:7789 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

History

Formulation

Chemistry

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Orphenadrine connects Entity context

The extracted context around Orphenadrine shows recurring relationship patterns in the source. For example, Orphenadrine → Cincinnati, Director, Fred Huber, George Rieveschl, In, Parke-Davis, Parkinson's, Prior, Research, Rieveschl, University, While Another extracted example is Orphenadrine → H1, Ki, Nav1, NDRI, NMDA, Nonselective, These, Various. Use these groups to spot repeated connection types before inspecting the individual relationships.

Orphenadrine

Top relations

related to history · 12
Orphenadrine → Cincinnati, Director, Fred Huber, George Rieveschl, In, Parke-Davis, Parkinson's, Prior, Research, Rieveschl, University, While
related to Pharmacology · 8
Orphenadrine → H1, Ki, Nav1, NDRI, NMDA, Nonselective, These, Various
Legal status · 5
Orphenadrine → AU: S4 (Prescription only), CA: OTC, NZ: Prescription only, UK: POM (Prescription only), US: ℞-only
has effect · 4
Orphenadrine → Common, Its, Parkinson's, Stimulation
related to Formulation · 2
Orphenadrine → February, US
3D model (JSmol) · 1
Orphenadrine → Interactive image
AHFS/Drugs.com · 1
Orphenadrine → Monograph
ATC code · 1
Orphenadrine → M03BC01 (WHO) N04AB02 (WHO)
Bioavailability · 1
Orphenadrine → 90%
CAS Number · 1
Orphenadrine → 83-98-7 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drugs pain drug anticholinergic diphenhydramine use muscle parkinson's antihistamines used effects one motor side antihistamine common class related relaxant treat

Orphenadrine relationships Subject–Predicate–Object triples

TTTA extracted 66 structured relationships around Orphenadrine. Examples in this analysis include Orphenadrine → 3D model (JSmol) → Interactive image and Orphenadrine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Orphenadrine3D model (JSmol)Interactive image1.00infobox
OrphenadrineAHFS/Drugs.comMonograph1.00infobox
OrphenadrineATC codeM03BC01 (WHO) N04AB02 (WHO)1.00infobox
OrphenadrineBioavailability90%1.00infobox
OrphenadrineCAS Number83-98-7 Y1.00infobox
OrphenadrineChEBICHEBI:7789 Y1.00infobox
OrphenadrineChEMBLChEMBL900 Y1.00infobox
OrphenadrineChemSpider4440 Y1.00infobox
OrphenadrineCompTox Dashboard (EPA)DTXSID30233961.00infobox
OrphenadrineDrugBankDB01173 Y1.00infobox
OrphenadrineECHA InfoCard100.001.3721.00infobox
OrphenadrineElimination half-life13–20 hours1.00infobox
OrphenadrineExcretionRenal and biliary1.00infobox
OrphenadrineFormulaC18H23NO1.00infobox
OrphenadrineIUPHAR/BPS72511.00infobox
OrphenadrineKEGGD08305 Y1.00infobox
OrphenadrineLegal statusAU: S4 (Prescription only)1.00infobox
OrphenadrineLegal statusCA: OTC1.00infobox
OrphenadrineLegal statusNZ: Prescription only1.00infobox
OrphenadrineLegal statusUK: POM (Prescription only)1.00infobox
OrphenadrineLegal statusUS: ℞-only1.00infobox
OrphenadrineMedlinePlusa6821621.00infobox
OrphenadrineMetabolismHepatic demethylation1.00infobox
OrphenadrineMolar mass269.388 g·mol−11.00infobox
OrphenadrinePregnancy categoryAU: B21.00infobox
OrphenadrineProtein binding95%1.00infobox
OrphenadrinePubChem CID46011.00infobox
OrphenadrineRoutes of administrationOral, intravenous, intramuscular1.00infobox
OrphenadrineUNIIAL805O9OG91.00infobox
Orphenadrineis aanticholinergic drug of the ethanolamine antihistamine class0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Orphenadrine bring nearby vocabulary together. In this analysis, examples include Drugs, Pain and Use. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Orphenadrine
    • Drugs
    • Pain
    • Use
    • Diphenhydramine
    • Effects
    • Muscle
    • Parkinson's
    • Acute
    • Aspirin
    • Effective
    • Efficacy
    • Evidence
  • orphenadrine
    • Drugs
    • Pain
    • Use
    • Diphenhydramine
    • Effects
    • Muscle
    • Parkinson's
    • Acute
    • Aspirin
    • Effective
    • Efficacy
    • Evidence
  • drug
    • Ethanolamine
    • Pain
    • Drugs
    • Acute
    • Antihistamine
    • Class
    • Disease
    • Effective
    • Efficacy
    • Evidence
    • Found
    • Help
  • dirty drug
    • Ethanolamine
    • Pain
    • Drugs
    • Acute
    • Antihistamine
    • Class
    • Disease
    • Effective
    • Efficacy
    • Evidence
    • Found
    • Help
  • muscle relaxant
    • Pain
    • Used
    • Relaxant
    • Treat
    • Chemistry
    • Medlineplus
    • Number
    • Superseded
    • Us
    • Effects
    • Side
    • Drugs
  • anticholinergic
    • Class
    • Ethanolamine
    • Use
    • Antagonist
    • Antihistamine
    • Disease
    • Efficacy
    • Found
    • Related
    • Review
    • Motor
    • Orphenadrine
  • parkinson's disease
    • Motor
    • Parkinson's
    • Superseded
    • Use
    • Found
    • Help
    • Largely
    • Relaxant
    • Review
    • Treat
    • Drugs
    • Drug
  • side effects
    • Side
    • Common
    • Muscle
    • Number
    • Us
    • Antagonist
    • Chemistry
    • Efficacy
    • Medlineplus
    • Relaxant
    • Antihistamines
    • Orphenadrine

Connections between topic areas Semantic bridges

For Orphenadrine, one of the stronger structural bridges in this analysis connects Orphenadrine with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Orphenadrine — Pharmacology · splits 41 ⟂ 13
Orphenadrine — Overview · splits 45 ⟂ 9
Orphenadrine — Side effects · splits 46 ⟂ 8
Orphenadrine — Chemistry · splits 47 ⟂ 7
Orphenadrine — Formulation · splits 48 ⟂ 6
Orphenadrine — Medical uses · splits 49 ⟂ 5
Orphenadrine — History · splits 49 ⟂ 5

Map overview Semantic statistics

Orphenadrine

Nodes54
Edges53
Triples66
Avg. degree1.96
Density0.037037
Components1

Source & methodology

TTTA analyzes the structure around Orphenadrine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Orphenadrine · EN edition · Analysis: TopicsToTalkAbout

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