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Ticlopidine

Ticlopidine, sold under the brand name Ticlid, is a medication used to reduce the risk of thrombotic strokes. It is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. However, because of its rare…

History & Applications

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History

DiscoverSanofiSyntexThe Roche group
4 related topics

Mechanism of action

P2Y12ADP receptor
2 related topics

Medical uses

Indicated
1 related topics

Overview

MedicationThienopyridineAdenosine diphosphateNeutropeniaThrombotic microangiopathy
7 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B01AC05 (WHO)
Bioavailability
>80%
CAS Number
55142-85-3 Y
ChEBI
CHEBI:9588 Y

Topics to explore

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Overview

Medical uses

Mechanism of action

History

Advanced semantic analysis

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Map overview Semantic statistics

Ticlopidine

Nodes19
Edges18
Triples107
Avg. degree1.89
Density0.105263
Components1

How this topic connects Entity context

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Ticlopidine

Top relations

related to history · 22
Ticlopidine → Apotex, April, As, Caraco, Castaigne, Castaigne SA, FDA, Fernand Eloy, France, Jean-Pierre Maffrand, Major, Par, Pharmacology, Roche, Sandoz, Sanofi, Starting, Syntex, Teva, The
related to Mechanism of action · 7
Ticlopidine → ADP, Anti-platelet, By, P2Y12, Therefore, Ticlopidine’s, Without ADP
related to External links · 6
Ticlopidine → April, Archived, August, Drug Information Portal, Medicine, National Library
related to Heart disease · 5
Ticlopidine → Current, FDA, However, Therefore, When
related to Interactions · 5
Ticlopidine → CYP2B6, CYP2C19, It, NSAIDs, Taking
related to Pharmacokinetics · 5
Ticlopidine → After, Clearance, Even, It, The
related to Research · 4
Ticlopidine → Due, FDA, However, Soon
Legal status · 3
Ticlopidine → EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
related to Chemical properties · 3
Ticlopidine → It, Its, Ticlopidine's
related to Contraindications · 3
Ticlopidine → History, Increased, The

Important terminology Word statistics

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Important terminology

effects drug strokes use studies blood risk side patients aspirin thrombotic antiplatelet liver days name medication however serious approved disease

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ticlopidine3D model (JSmol)Interactive image1.00infobox
TiclopidineAHFS/Drugs.comMonograph1.00infobox
TiclopidineATC codeB01AC05 (WHO)1.00infobox
TiclopidineBioavailability>80%1.00infobox
TiclopidineCAS Number55142-85-3 Y1.00infobox
TiclopidineChEBICHEBI:9588 Y1.00infobox
TiclopidineChEMBLChEMBL833 Y1.00infobox
TiclopidineChemSpider5273 Y1.00infobox
TiclopidineCompTox Dashboard (EPA)DTXSID50236691.00infobox
TiclopidineDrugBankDB00208 Y1.00infobox
TiclopidineECHA InfoCard100.054.0711.00infobox
TiclopidineElimination half-life12 hours (single dose) 4–5 days (repeated dosing)1.00infobox
TiclopidineExcretionKidney and fecal1.00infobox
TiclopidineFormulaC14H14ClNS1.00infobox
TiclopidineIUPHAR/BPS73071.00infobox
TiclopidineKEGGD08594 Y1.00infobox
TiclopidineKEGGas HCl: D010281.00infobox
TiclopidineLegal statusUS: ℞-only1.00infobox
TiclopidineLegal statusEU: Rx-only1.00infobox
TiclopidineLegal statusIn general: ℞ (Prescription only)1.00infobox
TiclopidineLicense dataUS DailyMed: Ticlopidine1.00infobox
TiclopidineMedlinePlusa6950361.00infobox
TiclopidineMetabolismLiver1.00infobox
TiclopidineMolar mass263.78 g·mol−11.00infobox
TiclopidinePregnancy categoryAU: B11.00infobox
TiclopidineProtein binding98%1.00infobox
TiclopidinePubChem CID54721.00infobox
TiclopidineRoutes of administrationBy mouth1.00infobox
TiclopidineTrade namesTiclid1.00infobox
TiclopidineUNIIOM90ZUW7M11.00infobox

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